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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

1,901–1,950 of 18,558 reactions from Rhea

L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)
Left to rightBalance undeterminableRhea 17989
gamma-L-glutamyl-L-cysteine + beta-alanine + ATP = gamma-L-glutamyl-L-cysteinyl-beta-alanine + ADP + phosphate + H(+)
Direction not assertedBalancedRhea 17993
Co-precorrin-2 + S-adenosyl-L-methionine = Co-precorrin-3 + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalancedRhea 17997
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)
Direction not assertedBalance undeterminableRhea 18001
D-threitol + NADP(+) = D-erythrulose + NADPH + H(+)
Direction not assertedBalancedRhea 18005
glutaryl-CoA + L-lysyl-[protein] = N(6)-glutaryl-L-lysyl-[protein] + CoA + H(+)
Left to rightBalance undeterminableRhea 18009

N(5)-ethyl-L-glutamine + H2O = ethylamine + L-glutamate

Direction not assertedBalancedRhea 18013

indole-3-pyruvate + H(+) = indole-3-acetaldehyde + CO2

Direction not assertedBalancedRhea 18017

a ganglioside GM1 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1a (d18:1(4E)) + CMP + H(+)

Left to rightBalance undeterminableRhea 18021

hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)

Direction not assertedBalancedRhea 18029

benzoate + reduced [NADPH--hemoprotein reductase] + O2 = 4-hydroxybenzoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 18033

agmatine + H2O = N-carbamoylputrescine + NH4(+)

Direction not assertedBalancedRhea 18037

6 oxidized [2Fe-2S]-[ferredoxin] + NH4(+) + 2 H2O = nitrite + 6 reduced [2Fe-2S]-[ferredoxin] + 8 H(+)

Direction not assertedBalance undeterminableRhea 18041

6-(alpha-D-glucose-1-phospho)-alpha-D-mannosyl derivative + H2O = alpha-D-mannose derivative + alpha-D-glucose 1-phosphate + H(+)

Direction not assertedBalance undeterminableRhea 18045

N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate

Direction not assertedBalancedRhea 18049

paraoxon + H2O = diethylphosphate + 4-nitrophenol + 2 H(+)

Direction not assertedBalancedRhea 18053

Watasenia luciferin + O2 = oxidized Watasenia luciferin + hnu + CO2

Direction not assertedBalance undeterminableRhea 18057

N-formylmethanofuran + 5,6,7,8-tetrahydromethanopterin + H(+) = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + methanofuran

Direction not assertedBalancedRhea 18061

phosphonate(out) + ATP + H2O = phosphonate(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 18065

L-arginine = D-arginine

Direction not assertedBalancedRhea 18069

(S)-dihydroorotate + A = orotate + AH2

Direction not assertedBalancedRhea 18073

L-arginyl-[dinitrogen reductase] + NAD(+) = N(omega)-alpha-(ADP-D-ribosyl)-L-arginyl-[dinitrogen reductase] + nicotinamide + H(+)

Direction not assertedBalance undeterminableRhea 18077

(2E,6E)-farnesyl diphosphate = pentalenene + diphosphate

Direction not assertedBalancedRhea 18081

methanophenazine + coenzyme B + coenzyme M = dihydromethanophenazine + coenzyme M-coenzyme B heterodisulfide

Direction not assertedBalancedRhea 18085

L-arginyl-[protein] + H2O = L-citrullyl-[protein] + NH4(+)

Left to rightBalance undeterminableRhea 18089

5,6-dihydrouracil + NADP(+) = uracil + NADPH + H(+)

Right to leftBalancedRhea 18093

pteridine-2,4,6,7-tetrol = xanthine-8-carboxylate + H(+)

Direction not assertedBalancedRhea 18097

cis-1,2-dihydro-3-ethylcatechol + NAD(+) = 3-ethylcatechol + NADH + H(+)

Direction not assertedBalancedRhea 18101

Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 18105

sn-3-O-(geranylgeranyl)glycerol 1-phosphate + (2E,6E,10E)-geranylgeranyl diphosphate = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + diphosphate

Direction not assertedBalancedRhea 18109

a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP

Left to rightBalance undeterminableRhea 18113

L-tyrosine + O2 = L-dopaquinone + H2O

Left to rightBalancedRhea 18117

an S-substituted L-cysteine + H2O = a thiol + pyruvate + NH4(+)

Left to rightBalance undeterminableRhea 18121

a D-alpha-amino acid + A + H2O = a 2-oxocarboxylate + AH2 + NH4(+)

Direction not assertedBalance undeterminableRhea 18125

2-oxoaldehyde + NADP(+) + H2O = a 2-oxocarboxylate + NADPH + 2 H(+)

Direction not assertedBalance undeterminableRhea 18129

sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate

Left to rightBalancedRhea 18133

3beta-hydroxy-5alpha-pregnane-20-one + NADP(+) = 5alpha-pregnane-3,20-dione + NADPH + H(+)

Direction not assertedBalancedRhea 18137

trans-cyclohexane-1,2-diol + NAD(+) = 2-hydroxycyclohexan-1-one + NADH + H(+)

Direction not assertedBalancedRhea 18141

beta-D-fructose + ATP = beta-D-fructose 1-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 18145

N-acetyl-D-galactosamine 6-phosphate + H2O = D-galactosamine 6-phosphate + acetate

Direction not assertedBalancedRhea 18149

2 GTP + H(+) = P(1),P(4)-bis(5'-guanosyl) tetraphosphate + diphosphate

Direction not assertedBalancedRhea 18153

pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)

Right to leftBalancedRhea 18157

tetradecanoyl-CoA + acetyl-CoA = 3-oxohexadecanoyl-CoA + CoA

Right to leftBalancedRhea 18161

biphenyl + NADH + O2 + H(+) = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+)

Direction not assertedBalancedRhea 18165

4-hydroxy-2-oxoglutarate = glyoxylate + pyruvate

Direction not assertedBalancedRhea 18169

(R)-octopamine = (4-hydroxyphenyl)acetaldehyde + NH4(+)

Direction not assertedBalancedRhea 18173

a 2,3-saturated acyl-CoA + NAD(+) = a (2E)-enoyl-CoA + NADH + H(+)

Direction not assertedBalance undeterminableRhea 18177

glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)

Direction not assertedBalancedRhea 18181

adenosine + O2 = 5'-dehydroadenosine + H2O2

Direction not assertedBalancedRhea 18185

[(1->4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1->4)-alpha-D-glucosyl](n+1) + ADP + H(+)

Direction not assertedBalance undeterminableRhea 18189

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