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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
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Articles

Chemistry

Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

1,851–1,900 of 18,558 reactions from Rhea

a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)
Left to rightBalance undeterminableRhea 17777
N(alpha)-formyl-L-methionine + H2O = formate + L-methionine
Left to rightBalancedRhea 17781
L-glutamate + H(+) = 4-aminobutanoate + CO2
Left to rightBalancedRhea 17785
(S)-3'-hydroxy-N-methylcoclaurine + S-adenosyl-L-methionine = (S)-reticuline + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalancedRhea 17789
L-alanyl-tRNA(Thr) + H2O = tRNA(Thr) + L-alanine + H(+)
Direction not assertedBalancedRhea 17793
[(1->4)-beta-D-glucosyl](n) + GDP-alpha-D-glucose = [(1->4)-beta-D-glucosyl](n+1) + GDP + H(+)
Direction not assertedBalance undeterminableRhea 17797
L-phenylalanine + acetyl-CoA = N-acetyl-L-phenylalanine + CoA + H(+)

Direction not assertedBalancedRhea 17801

S-adenosyl-L-homocysteine + H2O = S-(5-deoxy-D-ribos-5-yl)-L-homocysteine + adenine

Direction not assertedBalancedRhea 17805

Mg-protoporphyrin IX + S-adenosyl-L-methionine = Mg-protoporphyrin IX 13-monomethyl ester + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 17809

D-altronate + NAD(+) = keto-D-tagaturonate + NADH + H(+)

Direction not assertedBalancedRhea 17813

UDP-3-O-[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine + (3R)-hydroxytetradecanoyl-[ACP] = UDP-2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosamine + holo-[ACP] + H(+)

Direction not assertedBalance undeterminableRhea 17817

hydrogen cyanide + L-cysteine = 3-cyano-L-alanine + hydrogen sulfide + H(+)

Direction not assertedBalancedRhea 17821

D-glucose + ATP = D-glucose 6-phosphate + ADP + H(+)

Left to rightBalancedRhea 17825

3-hydroxyanthranilate + S-adenosyl-L-methionine = 3-hydroxy-4-methylanthranilate + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 17833

2-carboxy-D-arabinitol 1-phosphate + H2O = 2-carboxy-D-arabinitol + phosphate

Direction not assertedBalancedRhea 17837

trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP-N-acetyl-alpha-D-glucosamine = O-(N-acetyl-alpha-D-glucosaminyl)-trans-4-hydroxy-L-prolyl-[Skp1 protein] + UDP + H(+)

Direction not assertedBalance undeterminableRhea 17841

5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NADPH + H(+)

Direction not assertedBalancedRhea 17845

(3R)-3-hydroxybutanoyl-CoA = (2E)-butenoyl-CoA + H2O

Direction not assertedBalancedRhea 17849

keto-L-sorbose + O2 = 5-dehydro-D-fructose + H2O2

Direction not assertedBalancedRhea 17853

taurochenodeoxycholate + reduced [NADPH--hemoprotein reductase] + O2 = taurohyocholate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 17857

21-hydroxyprogesterone = 20-hydroxy-3-oxopregn-4-en-21-al

Direction not assertedBalancedRhea 17861

5,6,7,8-tetrahydropteridine + NADP(+) = 6,7-dihydropteridine + NADPH + H(+)

Right to leftBalancedRhea 17865

5,6,7,8-tetrahydropteridine + NAD(+) = 6,7-dihydropteridine + NADH + H(+)

Right to leftBalancedRhea 17869

an R-cob(III)alamin(out) + ATP + H2O = an R-cob(III)alamin(in) + ADP + phosphate + H(+)

Left to rightBalance undeterminableTransportRhea 17873

a catechol + S-adenosyl-L-methionine = a guaiacol + S-adenosyl-L-homocysteine + H(+)

Left to rightBalance undeterminableRhea 17877

N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate

Direction not assertedBalancedRhea 17881

acetaldehyde = acetylene + H2O

Direction not assertedBalancedRhea 17885

phosphoethanolamine + H2O = acetaldehyde + NH4(+) + phosphate

Direction not assertedBalancedRhea 17889

ethylbenzene + A + H2O = (S)-1-phenylethanol + AH2

Direction not assertedBalancedRhea 17897

xanthotoxol + S-adenosyl-L-methionine = xanthotoxin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 17901

(R)-glycerate + NAD(+) = 3-hydroxypyruvate + NADH + H(+)

Direction not assertedBalancedRhea 17905

(S)-lactate = acetaldehyde + formate

Direction not assertedBalancedRhea 17909

nitrite + NAD(+) + H2O = nitrate + NADH + H(+)

Direction not assertedBalancedRhea 17913

[Glu(-Cys)](n)-Gly + glutathione + H(+) = [Glu(-Cys)](n+1)-Gly + glycine

Direction not assertedBalance undeterminableRhea 17917

D-arabinitol + NAD(+) = D-xylulose + NADH + H(+)

Direction not assertedBalancedRhea 17921

alpha-L-arabinopyanose + NAD(+) = L-arabinono-1,4-lactone + NADH + H(+)

Direction not assertedBalancedRhea 17925

an N-acylsphing-4-enine + ATP = an N-acylsphing-4-enine 1-phosphate + ADP + H(+)

Left to rightBalance undeterminableRhea 17929

a 7-hydroxyisoflavone + S-adenosyl-L-methionine = a 7-methoxyisoflavone + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 17933

dihydroxyacetone phosphate = methylglyoxal + phosphate

Direction not assertedBalancedRhea 17937

(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O

Direction not assertedBalancedRhea 17941

(4S)-limonene + reduced [NADPH--hemoprotein reductase] + O2 = (1S,5R)-carveol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 17945

3-hydroxy-1H-quinolin-4-one + O2 = N-formylanthranilate + CO + H(+)

Direction not assertedBalancedRhea 17949

3-hydroxyanthranilate + O2 = (2Z,4Z)-2-amino-3-carboxymuconate 6-semialdehyde

Direction not assertedBalancedRhea 17953

3-oxopropanoate = propynoate + H2O

Direction not assertedBalancedRhea 17957

(5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate = leukotriene A4 + H2O

Left to rightBalancedRhea 17961

(R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate + H(+) = (8Z,11Z,14Z)-heptadecatrienal + CO2 + H2O

Direction not assertedBalancedRhea 17965

UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + L-lysine + ATP = UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 17969

IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate

Right to leftBalancedRhea 17973

a long-chain primary fatty alcohol + 2 NAD(+) + H2O = a long-chain fatty acid + 2 NADH + 3 H(+)

Direction not assertedBalance undeterminableRhea 17977

4-(trimethylamino)butanal + NAD(+) + H2O = 4-(trimethylamino)butanoate + NADH + 2 H(+)

Direction not assertedBalancedRhea 17985

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