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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Organisms
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSource

Reactions

18,601–18,650 of 31,435, by identifier

an N-acyl-15-methylhexadecasphing-4-enine + ATP = an N-acyl-15-methylhexadecasphing-4-enine-1-phosphate + ADP + H(+)
Direction not assertedBalance undeterminableRhea 34751
an N-acyl-1-beta-D-glucosyl-15-methylhexadecasphing-4-enine + H2O = an N-acyl-15-methylhexadecasphing-4-enine + D-glucose
Direction not assertedBalance undeterminableRhea 34755
glycerol 2-phosphate(out) + ATP + H2O = glycerol 2-phosphate(in) + ADP + phosphate + H(+)
Direction not assertedBalancedTransportRhea 34759
(S,S)-tartrate(out) + succinate(in) = (S,S)-tartrate(in) + succinate(out)
Direction not assertedBalancedTransportRhea 34763
(6R)-5,10-methenyltetrahydrofolate + H2O = (6S)-5-formyl-5,6,7,8-tetrahydrofolate + H(+)
Left to rightBalancedRhea 34767
a 3beta-hydroxysteroid-4alpha-carboxylate + NADP(+) = a 3-oxosteroid + CO2 + NADPH
Direction not assertedBalance undeterminable

Rhea 34771

a 3beta-hydroxysteroid-4alpha-carboxylate + NAD(+) = a 3-oxosteroid + CO2 + NADH

Direction not assertedBalance undeterminableRhea 34775

a 3alpha-hydroxysteroid + NAD(+) = a 3-oxosteroid + NADH + H(+)

Direction not assertedBalance undeterminableRhea 34779

a 3alpha-hydroxysteroid + NADP(+) = a 3-oxosteroid + NADPH + H(+)

Right to leftBalance undeterminableRhea 34783

a 3beta-hydroxysteroid + NADP(+) = a 3-oxosteroid + NADPH + H(+)

Right to leftBalance undeterminableRhea 34787

2-hydroxyethylphosphonate + O2 = hydroxymethylphosphonate + formate + H(+)

Direction not assertedBalancedRhea 34791

alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + H2O = alpha-D-ribose 1,5-bisphosphate + H(+)

Direction not assertedBalancedRhea 34795

2,3-didehydroadipoyl-CoA + acetyl-CoA = 3-oxo-5,6-didehydrosuberyl-CoA + CoA

Direction not assertedBalancedRhea 34799

2 4-coumaroyl-CoA + malonyl-CoA + H2O + H(+) = bisdemethoxycurcumin + 2 CO2 + 3 CoA

Direction not assertedBalancedRhea 34803

(R)-dihydrocamalexate + reduced [NADPH--hemoprotein reductase] + O2 = camalexin + oxidized [NADPH--hemoprotein reductase] + CO2 + 2 H2O

Direction not assertedBalance undeterminableRhea 34807

tetrahydrocurcumin + NADP(+) = dihydrocurcumin + NADPH + H(+)

Direction not assertedBalancedRhea 34811

tetrahydrocurcumin + 2 NADP(+) = curcumin + 2 NADPH + 2 H(+)

Direction not assertedBalancedRhea 34815

dihydrocurcumin + NADP(+) = curcumin + NADPH + H(+)

Direction not assertedBalancedRhea 34819

(E)-feruloylacetyl-CoA + (E)-feruloyl-CoA + H2O = curcumin + CO2 + 2 CoA

Direction not assertedBalancedRhea 34823

an N-acyl-15-methylhexadecasphing-4-enine-1-phosphate + H2O = an N-acyl-15-methylhexadecasphing-4-enine + phosphate

Direction not assertedBalance undeterminableRhea 34831

an N-acyl-4-hydroxy-15-methylhexadecasphinganine + a 1,2-diacyl-sn-glycero-3-phosphocholine = N-acyl-4-hydroxy-15-methylhexadecasphinganine-1-phosphocholine + a 1,2-diacyl-sn-glycerol

Direction not assertedBalance undeterminableRhea 34835

5 malonyl-CoA + 4 H(+) = 5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + 5 CoA + H2O

Direction not assertedBalancedRhea 34839

7,8-dihydromonapterin 3'-triphosphate + 3 H2O = 7,8-dihydromonapterin + 3 phosphate + 2 H(+)

Direction not assertedBalancedRhea 34843

7,8-dihydromonapterin + NADPH + H(+) = 5,6,7,8-tetrahydromonapterin + NADP(+)

Direction not assertedBalancedRhea 34847

(3S)-3-hydroxyadipyl-CoA + NAD(+) = 3-oxoadipyl-CoA + NADH + H(+)

Direction not assertedBalancedRhea 34851

iminodiacetonitrile + 2 H2O = N-(cyanomethyl)glycine + NH4(+)

Direction not assertedBalancedRhea 34855

3-oxocyclopentanecarbonitrile + 2 H2O = 3-oxocyclopentanecarboxylate + NH4(+)

Direction not assertedBalancedRhea 34859

thiophene-2-carboxylate + ATP + CoA = thiophene-2-carbonyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 34867

methanol(out) = methanol(in)

Direction not assertedBalancedTransportRhea 34871

2-oxepin-2(3H)-ylideneacetyl-CoA + NADP(+) + 2 H2O = 3-oxo-5,6-didehydrosuberyl-CoA + NADPH + 2 H(+)

Direction not assertedBalancedRhea 34875

methyl 3-cyano-2-phenylpropanoate + 2 H2O = 4-methoxy-4-oxo-3-phenylbutanoate + NH4(+)

Direction not assertedBalancedRhea 34879

selenate(out) + ATP + H2O = selenate(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 34883

selenate(in) = selenate(out)

Direction not assertedBalancedTransportRhea 34887

selenite(in) = selenite(out)

Direction not assertedBalancedTransportRhea 34891

selenite(out) + ATP + H2O = selenite(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 34895

malonyl-CoA + S-adenosyl-L-methionine = malonyl-CoA methyl ester + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 34899

selenite + 4 glutathione + 2 H(+) = selenodiglutathione + glutathione disulfide + 3 H2O

Direction not assertedBalancedRhea 34903

molybdate(in) = molybdate(out)

Direction not assertedBalancedTransportRhea 34907

D-methionine(in) = D-methionine(out)

Direction not assertedBalancedTransportRhea 34911

D-galactose(in) = D-galactose(out)

Direction not assertedBalancedTransportRhea 34915

thiamine(in) = thiamine(out)

Right to leftBalancedTransportRhea 34919

nitrate(in) = nitrate(out)

Direction not assertedBalancedTransportRhea 34923

selenodiglutathione + NADPH + H(+) = glutathioselenol + glutathione + NADP(+)

Direction not assertedBalancedRhea 34927

glutathioselenol + NADPH = hydrogenselenide + glutathione + NADP(+)

Direction not assertedBalancedRhea 34931

2 ATP + H(+) = P(1),P(4)-bis(5'-adenosyl) tetraphosphate + diphosphate

Left to rightBalancedRhea 34935

selenite + menaquinone-8 + H2O = selenate + menaquinol-8

Direction not assertedBalancedRhea 34939

hydroquinone O-beta-D-glucopyranoside(out) + phosphoenolpyruvate(in) = arbutin 6-phosphate(in) + pyruvate(in)

Direction not assertedBalancedRhea 34943

(Z)-3-aminoacrylate + H2O + H(+) = 3-oxopropanoate + NH4(+)

Direction not assertedBalancedRhea 34947

3-hydroxypropanoate(out) = 3-hydroxypropanoate(in)

Direction not assertedBalancedTransportRhea 34951

5-(methylsulfanyl)-D-ribose(in) = 5-(methylsulfanyl)-D-ribose(out)

Direction not assertedBalancedTransportRhea 34955

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