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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Interactions
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Chemistry

Reactions
Reach

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Cell types
Organisms
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

1,801–1,850 of 18,558 reactions from Rhea

myo-inositol + S-adenosyl-L-methionine = 1D-1-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalancedRhea 17565
(R)-reticuline + NADP(+) = 1,2-dehydroreticuline + NADPH + H(+)
Direction not assertedBalancedRhea 17569
demethylmacrocin + S-adenosyl-L-methionine = macrocin + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalancedRhea 17573
ADP-D-glycero-beta-D-manno-heptose = ADP-L-glycero-beta-D-manno-heptose
Direction not assertedBalancedRhea 17577
an N-carbamoyl-L-alpha-amino acid + H2O + 2 H(+) = an L-alpha-amino acid + NH4(+) + CO2
Direction not assertedBalance undeterminableRhea 17581
2,2'-iminodipropanoate + NAD(+) + H2O = L-alanine + pyruvate + NADH + H(+)
Direction not assertedBalancedRhea 17589
3-phenylpyruvate + L-glutamine = 2-oxoglutaramate + L-phenylalanine

Direction not assertedBalancedRhea 17593

D-mannitol + 2 Fe(III)-[cytochrome c] = D-fructose + 2 Fe(II)-[cytochrome c] + 2 H(+)

Direction not assertedBalance undeterminableRhea 17597

D-ribulose + ATP = D-ribulose 5-phosphate + ADP + H(+)

Left to rightBalancedRhea 17601

C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine + ATP = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + ADP + phosphate + H(+)

Direction not assertedBalance undeterminableRhea 17605

L-seryl-[sulfatase] + S-adenosyl-L-methionine = 3-oxo-L-alanyl-[sulfatase] + 5'-deoxyadenosine + L-methionine + H(+)

Direction not assertedBalance undeterminableRhea 17609

scyllo-inositol + NAD(+) = scyllo-inosose + NADH + H(+)

Direction not assertedBalancedRhea 17613

leukotriene C4 = leukotriene A4 + glutathione

ReversibleBalancedRhea 17617

citramalate + acetyl-CoA = (3S)-citramalyl-CoA + acetate

Direction not assertedBalancedRhea 17621

D-lysopine + NADP(+) + H2O = L-lysine + pyruvate + NADPH + H(+)

Direction not assertedBalancedRhea 17625

alpha,alpha-trehalose(in) = alpha,alpha-trehalose(out)

Right to leftBalancedTransportRhea 17629

a beta-D-glucuronoside + H2O = D-glucuronate + an alcohol

Left to rightBalance undeterminableRhea 17633

squalene = hop-22(29)-ene

Direction not assertedBalancedRhea 17637

L-arginine + H(+) = agmatine + CO2

Direction not assertedBalancedRhea 17641

N(6)-(5-O-phospho-D-ribulosyl)-L-lysyl-[protein] + H2O = N(6)-D-ribulosyl-L-lysyl-[protein] + phosphate

Direction not assertedBalance undeterminableRhea 17645

acetyl-[ACP] + malonate = malonyl-[ACP] + acetate

Direction not assertedBalance undeterminableRhea 17649

isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = (2E,6E,10E)-geranylgeranyl diphosphate + diphosphate

Direction not assertedBalancedRhea 17653

dihydroxyacetone phosphate + an acyl-CoA = a 1-acylglycerone 3-phosphate + CoA

Left to rightBalance undeterminableRhea 17657

succinate + ATP + CoA = succinyl-CoA + ADP + phosphate

Direction not assertedBalancedRhea 17661

octanoyl-[ACP] + L-lysyl-[protein] = N(6)-octanoyl-L-lysyl-[protein] + holo-[ACP] + H(+)

Left to rightBalance undeterminableRhea 17665

3-(2-hydroxyphenyl)propanoate + NADH + O2 + H(+) = 3-(2,3-dihydroxyphenyl)propanoate + NAD(+) + H2O

Direction not assertedBalancedRhea 17669

quercetin + S-adenosyl-L-methionine = 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 17673

2-(acetamidomethylene)-3-(hydroxymethyl)succinate + 2 H2O + H(+) = 2-(hydroxymethyl)-4-oxobutanoate + acetate + NH4(+) + CO2

Direction not assertedBalancedRhea 17677

3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)

Direction not assertedBalancedRhea 17681

uracil 5-carboxylate + H(+) = uracil + CO2

Direction not assertedBalancedRhea 17685

glycochenodeoxycholate + 3'-phosphoadenylyl sulfate = glycochenodeoxycholate 7-sulfate + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalancedRhea 17689

pyridine + thiamine = heteropyrithiamine + 5-(2-hydroxyethyl)-4-methylthiazole

Direction not assertedBalancedRhea 17697

geranoyl-CoA + hydrogencarbonate + ATP = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 17701

all-trans-nonaprenyl diphosphate + 4-hydroxybenzoate = 4-hydroxy-3-(all-trans-nonaprenyl)benzoate + diphosphate

Left to rightBalancedRhea 17709

(R)-reticuline + reduced [NADPH--hemoprotein reductase] + O2 = salutaridine + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 17713

1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + H(+)

Direction not assertedBalancedRhea 17717

a long-chain 2,3-saturated fatty acyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = a long-chain (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]

Left to rightBalance undeterminableRhea 17721

(2S,3S)-2-methylcitrate = 2-methyl-cis-aconitate + H2O

Direction not assertedBalancedRhea 17725

an acyl-CoA + cholesterol = a cholesterol ester + CoA

Left to rightBalance undeterminableRhea 17729

acetylenedicarboxylate + H2O + H(+) = pyruvate + CO2

Direction not assertedBalancedRhea 17733

shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)

Direction not assertedBalancedRhea 17737

shikimate + NAD(+) = 3-dehydroshikimate + NADH + H(+)

Direction not assertedBalancedRhea 17741

N-acetyl-D-glucosamine + UDP-alpha-D-galactose = beta-D-galactosyl-(1->4)-N-acetyl-D-glucosamine + UDP + H(+)

Left to rightBalancedRhea 17745

quinoline + A + H2O = quinolin-2(1H)-one + AH2

Direction not assertedBalancedRhea 17749

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine

Direction not assertedBalancedRhea 17753

L-methionine + H(+) = 3-(methylsulfanyl)propanamine + CO2

Direction not assertedBalancedRhea 17757

an aromatic primary alcohol + NADP(+) = an aromatic aldehyde + NADPH + H(+)

Direction not assertedBalance undeterminableRhea 17761

(2R)-3-phospho-glyceroyl phosphate = (2R)-2,3-bisphosphoglycerate + H(+)

ReversibleBalancedRhea 17765

choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 17769

tRNA(Cys) + L-cysteine + ATP = L-cysteinyl-tRNA(Cys) + AMP + diphosphate

ReversibleBalancedRhea 17773

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