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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Reactions
Reach

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Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

1,751–1,800 of 18,558 reactions from Rhea

(S)-methylmalonyl-CoA + H2O = methylmalonate + CoA + H(+)
Direction not assertedBalancedRhea 17345
3-[(Z)-2-isocyanoethenyl]-1H-indole + (2E)-geranyl diphosphate = 3-geranyl-3-[(Z)-2-isocyanoethenyl]-1H-indole + diphosphate
Direction not assertedBalancedRhea 17349
2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2
Left to rightBalance undeterminableRhea 17357
3-oxo-3-ureidopropanoate + H2O = malonate + urea + H(+)
Direction not assertedBalancedRhea 17361
Mn(2+)(out) + ATP + H2O = Mn(2+)(in) + ADP + phosphate + H(+)
Direction not assertedBalancedTransportRhea 17365
glycyrrhizin + H2O = 2-(beta-D-glucuronosyl)-D-glucuronate + glycyrrhetinate
Direction not assertedBalancedRhea 17369
all-trans-antheraxanthin = all-trans-capsanthin

Direction not assertedBalancedRhea 17373

a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)

Left to rightBalance undeterminableRhea 17377

(9Z,12Z)-octadecadienoate = (9Z,11E)-octadecadienoate

Direction not assertedBalancedRhea 17381

D-arabinitol + NAD(+) = D-ribulose + NADH + H(+)

Direction not assertedBalancedRhea 17389

3-maleylpyruvate = 3-fumarylpyruvate

Direction not assertedBalancedRhea 17393

a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)

Right to leftBalance undeterminableRhea 17397

2-hydroxy-4-oxobutane-1,2,4-tricarboxylate = 4-carboxy-2-hydroxy-cis,cis-muconate + H2O

Direction not assertedBalancedRhea 17401

N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine = N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 17405

(S)-coclaurine + S-adenosyl-L-methionine = (S)-N-methylcoclaurine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 17409

a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-beta-D-glucosaminyl-(1->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP + H(+)

Direction not assertedBalance undeterminableRhea 17413

N-acetyl-D-glucosamine + ATP = N-acetyl-D-glucosamine 6-phosphate + ADP + H(+)

Left to rightBalancedRhea 17417

pyruvate + NADP(+) + CoA = acetyl-CoA + CO2 + NADPH

Direction not assertedBalancedRhea 17425

trans-4-hydroxycyclohexane-1-carboxylate + NAD(+) = 4-oxocyclohexane-1-carboxylate + NADH + H(+)

Direction not assertedBalancedRhea 17429

choline + A = betaine aldehyde + AH2

Left to rightBalancedRhea 17433

2-(2,4-dichloro-5-oxo-2,5-dihydrofuryl)acetate = (2E,4E)-2,4-dichloromuconate + H(+)

Direction not assertedBalancedRhea 17437

L-cysteine + 2-oxoglutarate = 2-oxo-3-sulfanylpropanoate + L-glutamate

ReversibleBalancedRhea 17441

H2 + 2 oxidized [2Fe-2S]-[ferredoxin] = 2 reduced [2Fe-2S]-[ferredoxin] + 2 H(+)

Direction not assertedBalance undeterminableRhea 17445

flaviolin + (2E)-geranyl diphosphate = 3-linalylflaviolin + diphosphate

Direction not assertedBalancedRhea 17449

5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)

Left to rightBalancedRhea 17453

L-cysteinyl-[cysteine desulfurase] + L-cysteine = S-sulfanyl-L-cysteinyl-[cysteine desulfurase] + L-alanine

Direction not assertedBalance undeterminableRhea 17457

D-sedoheptulose 1,7-bisphosphate + H2O = D-sedoheptulose 7-phosphate + phosphate

Direction not assertedBalancedRhea 17461

quercitrin + H2O = L-rhamnopyranose + quercetin

Direction not assertedBalancedRhea 17465

all-trans-retinol--[retinol-binding protein] + a 1,2-diacyl-sn-glycero-3-phosphocholine = apo--[retinol-binding protein] + an all-trans-retinyl ester + a 2-acyl-sn-glycero-3-phosphocholine

Left to rightBalance undeterminableRhea 17469

GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)

Direction not assertedBalancedRhea 17473

precorrin-6B + 2 S-adenosyl-L-methionine = precorrin-8X + 2 S-adenosyl-L-homocysteine + CO2 + 3 H(+)

Direction not assertedBalancedRhea 17477

2 cob(I)alamin + NAD(+) + H(+) = 2 cob(II)alamin + NADH

Direction not assertedBalancedRhea 17481

(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate

Left to rightBalancedRhea 17485

phthalate + NADH + O2 + H(+) = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)

Direction not assertedBalancedRhea 17489

glycerol + A = dihydroxyacetone + AH2

Direction not assertedBalancedRhea 17493

formononetin + UDP-alpha-D-glucose = ononin + UDP

Direction not assertedBalancedRhea 17497

polyneuridine aldehyde + H2O = 16-epivellosimine + methanol + CO2

Direction not assertedBalancedRhea 17501

an N-(long-chain fatty acyl)ethanolamine + H2O = a long-chain fatty acid + ethanolamine

Left to rightBalance undeterminableRhea 17505

thiamine + H2O = 5-(2-hydroxyethyl)-4-methylthiazole + 4-amino-5-hydroxymethyl-2-methylpyrimidine + H(+)

Direction not assertedBalancedRhea 17509

an N-(long-chain-fatty-acyl)-L-glutamate + H2O = a long-chain fatty acid + L-glutamate

Direction not assertedBalance undeterminableRhea 17517

L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 17521

biuret + H2O = urea-1-carboxylate + NH4(+)

Direction not assertedBalancedRhea 17525

an aromatic L-alpha-amino acid + 2-oxoglutarate = an aromatic oxo-acid + L-glutamate

Direction not assertedBalance undeterminableRhea 17533

(R)-carnitinamide + H2O = (R)-carnitine + NH4(+)

Direction not assertedBalancedRhea 17537

an aromatic primary alcohol + O2 = an aromatic aldehyde + H2O2

Direction not assertedBalance undeterminableRhea 17541

S-hydroxy-S-oxy-L-cysteinyl-[peroxiredoxin] + [protein]-dithiol + ATP = S-hydroxy-L-cysteinyl-[peroxiredoxin] + [protein]-disulfide + ADP + phosphate

Direction not assertedBalance undeterminableRhea 17545

a 1-acyl-2-(9Z)-enoyl-sn-glycero-3-phospholipid + S-adenosyl-L-methionine = a 1-acyl-2-(10-methylene)-acyl-sn-glycero-3-phospholipid + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 17549

guanidinoethyl methyl phosphate + ATP = N'-phosphoguanidinoethyl methylphosphate + ADP + H(+)

Direction not assertedBalancedRhea 17553

anthranilate + malonyl-CoA = N-malonylanthranilate + CoA

Direction not assertedBalancedRhea 17557

acetylcholine + H2O = choline + acetate + H(+)

Left to rightBalancedRhea 17561

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