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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

17,751–17,800 of 18,558 reactions from Rhea

didehydrocampesine A + 2 AH2 = campesine A + 2 A
Direction not assertedBalancedRhea 83463
a neolactoside IV3-a-Gal-nLc4Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside IV(3)-alpha-Gal,III(3)-alpha-Fuc-nLc4Cer(d18:1(4E)) + GDP + H(+)
Direction not assertedBalance undeterminableRhea 83467
a neolactoside IV(3)-alpha-GalNAc,IV(2)-alpha-Fuc-nLc4Cer + H2O = a neolactoside IV(2)-alpha-Fuc-nLc4Cer + N-acetyl-alpha-D-galactosamine
Direction not assertedBalance undeterminableRhea 83471
a neolactoside VI(3)-alpha-NeuGc-nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside VI(3)-alpha-NeuGc,III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+)
Direction not assertedBalance undeterminableRhea 83475
L-tryptophan + ATP + NADPH + H(+) = L-tryptophanal + AMP + diphosphate + NADP(+)
Direction not assertedBalancedRhea 83479
S-sulfanyl-L-cysteinyl-[cysteine desulfurase] + L-cysteinyl-[protein] = S-sulfanyl-L-cysteinyl-[protein] + L-cysteinyl-[cysteine desulfurase]

? Direction not asserted

Balance undeterminable

Rhea 83483

N(alpha)-formyl-L-methionyl-L-phenylalanine + H2O = N(alpha)-formyl-L-methionine + L-phenylalanine

Left to rightBalancedRhea 83487

N(alpha)-formyl-L-methionyl-L-alanine + H2O = N(alpha)-formyl-L-methionine + L-alanine

Left to rightBalancedRhea 83491

N(alpha)-formyl-L-methionyl-L-alanyl-L-serine + H2O = L-alanyl-L-serine + N(alpha)-formyl-L-methionine

Left to rightBalancedRhea 83495

N(alpha)-formyl-L-methionyl-L-serine + H2O = N(alpha)-formyl-L-methionine + L-serine

Left to rightBalancedRhea 83499

N(alpha)-acetyl-L-methionyl-L-alanyl-L-serine + H2O = L-alanyl-L-serine + N-acetyl-L-methionine

Left to rightBalancedRhea 83503

N(alpha)-acetyl-L-alanyl-L-alanine + H2O = N(alpha)-acetyl-L-alanine + L-alanine

Left to rightBalancedRhea 83507

N(alpha)-acetyl-L-alanyl-L-alanyl-L-alanine + H2O = N(alpha)-acetyl-L-alanine + L-alanyl-L-alanine

Left to rightBalancedRhea 83511

a neolactoside VI(3)-alpha-NeuNAc-nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside VI(3)-alpha-NeuAc,V(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+)

Direction not assertedBalance undeterminableRhea 83515

a neolactoside VI(3)-alpha-NeuNAc-nLc6Cer(d18:1(4E)) + GDP-beta-L-fucose = a neolactoside VI(3)-alpha-NeuAc,III(3)-alpha-Fuc-nLc6Cer(d18:1(4E)) + GDP + H(+)

Direction not assertedBalance undeterminableRhea 83519

3-O-(beta-D-glucopyranosyl)-2alpha-hydroxyisomotiol + acetyl-CoA = 3-O-(beta-D-glucopyranosyl)-2alpha-acetoxyisomotiol + CoA

Direction not assertedBalancedRhea 83523

2-deacetylfuscoatroside + acetyl-CoA = fuscoatroside + CoA

Direction not assertedBalancedRhea 83527

benzoyl-CoA + L-lysyl-[protein] = N(6)-benzoyl-L-lysyl-[protein] + CoA + H(+)

Direction not assertedBalance undeterminableRhea 83531

N(6)-benzoyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-benzoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]

Left to rightBalance undeterminableRhea 83535

isonicotinyl-CoA + L-lysyl-[protein] = N(6)-isonicotinyl-L-lysyl-[protein] + CoA + H(+)

Left to rightBalance undeterminableRhea 83539

N(6)-isonicotinyl-L-lysyl-[protein] + H2O = isonicotinate + L-lysyl-[protein]

Left to rightBalance undeterminableRhea 83543

2-methylpropenoyl-CoA + L-lysyl-[protein] = N(6)-methacrylyl-L-lysyl-[protein] + CoA + H(+)

Left to rightBalance undeterminableRhea 83547

N(6)-methacrylyl-L-lysyl-[protein] + H2O = 2-methylprop-2-enoate + L-lysyl-[protein]

Direction not assertedBalance undeterminableRhea 83551

chloroethene + reduced [NADPH--hemoprotein reductase] + O2 = chloroethylene oxide + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 83555

octadecanal + reduced [NADPH--hemoprotein reductase] + O2 = heptadecane + oxidized [NADPH--hemoprotein reductase] + CO2 + H2O + H(+)

Direction not assertedBalance undeterminableRhea 83559

a long-chain fatty aldehyde + reduced [NADPH--hemoprotein reductase] + O2 = a long-chain alkane + oxidized [NADPH--hemoprotein reductase] + CO2 + H2O + H(+)

Direction not assertedBalance undeterminableRhea 83563

a 1,N(6)-etheno-2'-deoxyadenosine in double-stranded DNA + H2O = 1,N(6)-ethenoadenine + a 2'-deoxyribose 5'-monophosphate in double-stranded DNA

Direction not assertedBalance undeterminableRhea 83567

a 3,N(4)-etheno-2'-deoxycytidine in double-stranded DNA + H2O = 3,N(4)-ethenocytosine + a 2'-deoxyribose 5'-monophosphate in double-stranded DNA

Direction not assertedBalance undeterminableRhea 83571

L-thyroxine + 3'-phosphoadenylyl sulfate = L-thyroxine sulfate + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalancedRhea 83575

(S,S)-2,5-di-(p-hydroxybenzyl)piperazine + reduced [NADPH--hemoprotein reductase] + O2 = (1S,4S)-4-[(4-hydroxyphenyl)methyl]-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexane]-2',5'-dien-4'-one + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 83579

(1S,4S)-4-[(4-hydroxyphenyl)methyl]-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexane]-2',5'-dien-4'-one + 2 NADPH + 2 H(+) = (1S,4S)-4-[(4-hydroxyphenyl)methyl]-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + 2 NADP(+)

Direction not assertedBalancedRhea 83583

(1S,4S)-4-[(4-hydroxyphenyl)methyl]-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-methionine = (1S,4S)-4-[(4-hydroxyphenyl)methyl]-2-methyl-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 83587

(1S,4S)-4-[(4-hydroxyphenyl)methyl]-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-methionine = (1S,4S)-4-[(4-methoxyphenyl)methyl]-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 83591

(1S,4S)-4-[(4-hydroxyphenyl)methyl]-2-methyl-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-methionine = (1S,4S)-4-[(4-methoxyphenyl)methyl]-2-methyl-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 83595

(1S,4S)-4-[(4-methoxyphenyl)methyl]-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-methionine = (1S,4S)-4-[(4-methoxyphenyl)methyl]-2-methyl-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 83599

(1S,4S)-4-[(4-methoxyphenyl)methyl]-2-methyl-2,5-diazaspiro[bicyclo[3.2.1]octane-6,1'-cyclohexan]-4'-one + 2-oxoglutarate + O2 = (2S)-3-(4-methoxyphenyl)-2-[(3S)-3-(methylamino)-8-oxo-1-azaspiro[4.5]decan-1-yl]propanal + succinate + CO2

Direction not assertedBalancedRhea 83603

(2S)-3-(4-methoxyphenyl)-2-[(3S)-3-(methylamino)-8-oxo-1-azaspiro[4.5]decan-1-yl]propanal = (1S,3S,6S,7S,8R)-7-hydroxy-6-[(4-methoxyphenyl)methyl]-3-(methylamino)-5-azatricyclo[6.3.1.0(1,5)]dodecan-9-one

Direction not assertedBalancedRhea 83607

(1S,3S,6S,7S,8R)-7-hydroxy-6-[(4-methoxyphenyl)methyl]-3-(methylamino)-5-azatricyclo[6.3.1.0(1,5)]dodecan-9-one + NADPH + H(+) = (1S,3S,6S,7S,8S,9S)-6-[(4-methoxyphenyl)methyl]-3-(methylamino)-5-azatricyclo[6.3.1.0(1,5)]dodecane-7,9-diol + NADP(+)

Direction not assertedBalancedRhea 83611

(1S,3S,6S,7S,8S,9S)-6-[(4-methoxyphenyl)methyl]-3-(methylamino)-5-azatricyclo[6.3.1.0(1,5)]dodecane-7,9-diol + ATP = (-)-FR901483 + ADP + 2 H(+)

Direction not assertedBalancedRhea 83615

a 1,N(2)-etheno-2'-deoxyguanosine in double-stranded DNA + H2O = 1,N(2)-ethenoguanine + a 2'-deoxyribose 5'-monophosphate in double-stranded DNA

Direction not assertedBalance undeterminableRhea 83619

a N(2),3-etheno-2'-deoxyguanosine in double-stranded DNA + H2O = N(2),3-ethenoguanine + a 2'-deoxyribose 5'-monophosphate in double-stranded DNA

Direction not assertedBalance undeterminableRhea 83623

6-pyruvoyl-5,6,7,8-tetrahydropterin + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + H(+)

Direction not assertedBalancedRhea 83627

1,N(2)-ethenoguanine + O2 + H2O = 2-oxo-ethenoguanine + H2O2

Direction not assertedBalancedRhea 83631

uridine in 28S rRNA + S-adenosyl-L-methionine = N(3)-methyluridine in 28S rRNA + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 83635

7-(2'-oxo-heptyl)-1,N(2)-ethenoguanine + O2 + H2O = 7-(2'-oxo-heptyl)-2-oxo-ethenoguanine + H2O2

Direction not assertedBalancedRhea 83639

L-sepiapterin + hnu + 2 O2 + H2O = 2-amino-4-oxopteridine-6-carboxylate + acetaldehyde + 2 H2O2 + H(+)

Direction not assertedBalance undeterminableRhea 83643

chloroethylene oxide + a 2'-deoxyadenosine in double-stranded DNA = a 1,N(6)-etheno-2'-deoxyadenosine in double-stranded DNA + chloride + H2O + H(+)

Direction not assertedBalance undeterminableRhea 83647

deacetylisoipecoside + S-adenosyl-L-methionine = 7-O-methyldeacetylisoipecoside + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 83651

3H-pyrimido[1,2-alpha]purin-10-one + O2 + H2O = 3H,5H-pyrimido[1,2-alpha]purin-6,10-dione + H2O2

Direction not assertedBalancedRhea 83655

3H,5H-pyrimido[1,2-alpha]purin-6,10-dione + O2 + H2O = 1H,3H,5H-pyrimido[1,2-alpha]purin-2,6,10-trione + H2O2

Direction not assertedBalancedRhea 83659

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