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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

17,601–17,650 of 18,558 reactions from Rhea

campesine C + campesine A + reduced [NADPH--hemoprotein reductase] + O2 = campesine E + oxidized [NADPH--hemoprotein reductase] + 2 H2O + 2 H(+)
Direction not assertedBalance undeterminableRhea 82839
campesine D + reduced [NADPH--hemoprotein reductase] + O2 = campesine G + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)
Direction not assertedBalance undeterminableRhea 82843
(2E)-geranylhydroquinone + reduced [NADPH--hemoprotein reductase] + O2 = wigandol + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)
Direction not assertedBalance undeterminableRhea 82847
2-methoxy-5-methyl-6-all-trans-hexaprenyl-1,4-benzoquinone + NADH + O2 = 3-demethylubiquinone-6 + NAD(+) + H2O
Direction not assertedBalancedRhea 82851
2-methoxy-5-methyl-6-all-trans-nonaprenyl-1,4-benzoquinone + NADH + O2 = 3-demethylubiquinone-9 + NAD(+) + H2O
Direction not assertedBalancedRhea 82855
2-methoxy-5-methyl-6-all-trans-decaprenyl-1,4-benzoquinone + NADH + O2 = 3-demethylubiquinone-10 + NAD(+) + H2O

? Direction not asserted

Balanced

Rhea 82859

Zn(2+)(in) + Ca(2+)(out) = Zn(2+)(out) + Ca(2+)(in)

Direction not assertedBalancedTransportRhea 82863

wigandol + 4 reduced [NADPH--hemoprotein reductase] + 4 O2 = arnebinol A + 4 oxidized [NADPH--hemoprotein reductase] + 6 H2O + 4 H(+)

Direction not assertedBalance undeterminableRhea 82867

arnebinol A + reduced [NADPH--hemoprotein reductase] + O2 = clavilactone A + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 82871

(2E)-geranylhydroquinone + reduced [NADPH--hemoprotein reductase] + O2 = isoalliodorol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 82875

3,5-diiodo-L-tyrosine(in) = 3,5-diiodo-L-tyrosine(out)

Direction not assertedBalancedTransportRhea 82879

3-iodo-L-tyrosine(in) = 3-iodo-L-tyrosine(out)

Direction not assertedBalancedTransportRhea 82883

indoxyl + 3'-phosphoadenylyl sulfate = indoxyl sulfate + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalancedRhea 82887

indoxyl sulfate(out) = indoxyl sulfate(in)

Right to leftBalancedTransportRhea 82891

3-iodo-L-thyronine + iodide + A + H(+) = 3,5-diiodo-L-thyronine + AH2

Right to leftBalancedRhea 82895

3'-iodo-L-thyronine + iodide + A + H(+) = 3',5'-diiodo-L-thyronine + AH2

Right to leftBalancedRhea 82899

a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc6S derivative + CMP + H(+)

Direction not assertedBalance undeterminableRhea 82903

a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-6-sulfooxy-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc6S derivative + CMP + H(+)

Direction not assertedBalance undeterminableRhea 82907

an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + 3'-phosphoadenylyl sulfate = a 6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalance undeterminableRhea 82911

a 6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = a beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP + H(+)

Direction not assertedBalance undeterminableRhea 82915

a thioester + H2O = a thiol + a carboxylate + H(+)

Direction not assertedBalance undeterminableRhea 82919

(2E,9Z)-hexadecadienoyl-CoA + H2O = (3S)-hydroxy-(9Z-hexadecenoyl)-CoA

Left to rightBalancedRhea 82923

(3S)-hydroxy-(9Z-hexadecenoyl)-CoA + NAD(+) = 3-oxo-(9Z-hexadecenoyl)-CoA + NADH + H(+)

Left to rightBalancedRhea 82931

3-oxo-(9Z-hexadecenoyl)-CoA + CoA = (7Z)-tetradecenoyl-CoA + acetyl-CoA

Left to rightBalancedRhea 82935

(7Z)-tetradecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,7Z)-tetradecadienoyl-CoA + reduced [electron-transfer flavoprotein]

Left to rightBalance undeterminableRhea 82939

3-oxo-(7Z)-tetradecenoyl-CoA + CoA = (5Z)-dodecenoyl-CoA + acetyl-CoA

Left to rightBalancedRhea 82943

an N(4)-{beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+)

Left to rightBalance undeterminableRhea 82947

(5Z)-dodecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,5Z)-dodecadienoyl-CoA + reduced [electron-transfer flavoprotein]

Left to rightBalance undeterminableRhea 82951

an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)

Direction not assertedBalance undeterminableRhea 82955

(2E,5Z)-dodecadienoyl-CoA + H2O = (3S)-hydroxy-(5Z)-dodecenoyl-CoA

Left to rightBalancedRhea 82959

an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-6-O-sulfo-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + 3'-phosphoadenylyl sulfate = an alpha-Neu5Ac-(2->3)-6-O-sulfo-beta-D-Gal-(1->4)-6-O-sulfo-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalance undeterminableRhea 82963

an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-galactose = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)

Direction not assertedBalance undeterminableRhea 82967

an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)

Direction not assertedBalance undeterminableRhea 82971

an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 3'-phosphoadenylyl sulfate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[6-O-sulfo-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalance undeterminableRhea 82975

an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[6-O-sulfo-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-alpha-D-galactose = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-6-O-sulfo-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)

Direction not assertedBalance undeterminableRhea 82979

an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-6-O-sulfo-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-6-O-sulfo-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+)

Direction not assertedBalance undeterminableRhea 82983

an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[beta-D-Gal-(1->4)-6-O-sulfo-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP-N-acetyl-beta-neuraminate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-6-O-sulfo-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + CMP + H(+)

Direction not assertedBalance undeterminableRhea 82987

an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-6-O-sulfo-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + 3'-phosphoadenylyl sulfate = an N(4)-{alpha-Neu5Ac-(2->6)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-Neu5Ac-(2->3)-6-O-sulfo-beta-D-Gal-(1->4)-6-O-sulfo-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalance undeterminableRhea 82991

(2E,7Z)-tetradecadienoyl-CoA + H2O = (3S)-hydroxy-(7Z)-tetradecenoyl-CoA

Left to rightBalancedRhea 82995

(3S)-hydroxy-(7Z)-tetradecenoyl-CoA + NAD(+) = 3-oxo-(7Z)-tetradecenoyl-CoA + NADH + H(+)

Left to rightBalancedRhea 82999

(3S)-hydroxy-(5Z)-dodecenoyl-CoA + NAD(+) = 3-oxo-(5Z)-dodecenoyl-CoA + NADH + H(+)

Left to rightBalancedRhea 83003

3-oxo-(5Z)-dodecenoyl-CoA + CoA = (3Z)-decenoyl-CoA + acetyl-CoA

Left to rightBalancedRhea 83007

L-erythro-biopterin + hnu + O2 = 2-amino-4-oxopteridine-6-carbaldehyde + acetaldehyde + H2O2

Direction not assertedBalance undeterminableRhea 83011

2-amino-4-oxopteridine-6-carbaldehyde + hnu + O2 + H2O = 2-amino-4-oxopteridine-6-carboxylate + H2O2 + H(+)

Direction not assertedBalance undeterminableRhea 83015

(11Z)-octadecenoate + ATP + CoA = (11Z)-octadecenoyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 83019

(11Z)-octadecenoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,11Z)-octadecadienoyl-CoA + reduced [electron-transfer flavoprotein]

Left to rightBalance undeterminableRhea 83023

(2E,11Z)-octadecadienoyl-CoA + H2O = (3S)-hydroxy-(11Z)-octadecenoyl-CoA

Left to rightBalancedRhea 83027

(3S)-hydroxy-(11Z)-octadecenoyl-CoA + NAD(+) = 3-oxo-(11Z)-octadecenoyl-CoA + NADH + H(+)

Left to rightBalancedRhea 83031

(11Z)-eicosenoate + ATP + CoA = (11Z)-eicosenoyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 83035

D-erythro-neopterin + hnu + O2 = 2-amino-4-oxopteridine-6-carbaldehyde + glycolaldehyde + H2O2

Direction not assertedBalance undeterminableRhea 83039

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