Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

17,501–17,550 of 18,558 reactions from Rhea

3-hydroxy-L-kynurenine + 3-phenylpyruvate = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-phenylalanine
Direction not assertedBalancedRhea 82431
(S)-2,3-epoxysqualene + reduced [NADPH--hemoprotein reductase] + O2 = (3S,22S)-2,3:22,23-diepoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Direction not assertedBalance undeterminableRhea 82435
nitarsone (III) + AH2 + O2 = 4-nitrocyclohexa-2,5-dien-1-one + arsenite + A + H(+)
Direction not assertedBalancedRhea 82439
4-aminophenylarsonous acid + AH2 + O2 = 4-aminocyclohexa-2,5-dien-1-one + arsenite + A
Direction not assertedBalancedRhea 82443
a N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoyloxy]acyl-beta-D-glucosyl-(1<->1)-sphing-4E-enine + NAD(+) = a N-[omega-(9R,10R)-epoxy-13-oxo-(11E)-octadecenoyloxy]acyl-beta-D-glucosyl-(1<->1)-sphing-4E-enine + NADH + H(+)
Left to rightBalance undeterminableRhea 82447
selenophosphate + UDP-alpha-D-glucose + H2O = 1-seleno-beta-D-glucose + UDP + phosphate + H(+)

? Direction not asserted

Balanced

Rhea 82451

selenophosphate + UDP-alpha-D-galactose + H2O = 1-seleno-beta-D-galactose + UDP + phosphate + H(+)

Direction not assertedBalancedRhea 82455

selenophosphate + UDP-N-acetyl-alpha-D-galactosamine + H2O = N-acetyl-1-seleno-beta-D-galactosamine + UDP + phosphate + H(+)

Direction not assertedBalancedRhea 82459

bromide + L-tryptophan + NADPH + O2 + 2 H(+) = 5-bromo-L-tryptophan + NADP(+) + 2 H2O

Direction not assertedBalancedRhea 82463

5-bromo-L-tryptophan + bromide + NADPH + O2 + 2 H(+) = 5,7-dibromo-L-tryptophan + NADP(+) + 2 H2O

Direction not assertedBalancedRhea 82467

a N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoyloxy]-acylsphing-4E-enine + NAD(+) = a N-[omega-(9R,10R)-epoxy-13-oxo-(11E)-octadecenoyloxy]-acylsphing-4E-enine + NADH + H(+)

Left to rightBalance undeterminableRhea 82471

hydroquinone + (2E)-geranyl diphosphate = (2E)-geranylhydroquinone + diphosphate

Direction not assertedBalancedRhea 82475

(R)-lactate + FAD + H(+) = FADH2 + pyruvate

Left to rightBalancedRhea 82479

(2R)-hydroxybutanoate + FAD + H(+) = 2-oxobutanoate + FADH2

Left to rightBalancedRhea 82483

(2R)-hydroxypentanoate + FAD + H(+) = 2-oxopentanoate + FADH2

Left to rightBalancedRhea 82487

(2R)-hydroxyhexanoate + FAD + H(+) = 2-oxohexanoate + FADH2

Left to rightBalancedRhea 82491

(2R)-hydroxyoctanoate + FAD + H(+) = 2-oxooctanoate + FADH2

Left to rightBalancedRhea 82495

(2R)-hydroxy-4-methylpentanoate + FAD + H(+) = 4-methyl-2-oxopentanoate + FADH2

Left to rightBalancedRhea 82499

(2R)-hydroxy-3-methylpentanoate + FAD + H(+) = 3-methyl-2-oxopentanoate + FADH2

Left to rightBalancedRhea 82503

(R)-3-phenyllactate + FAD + H(+) = 3-phenylpyruvate + FADH2

Left to rightBalancedRhea 82507

a (2R)-2-hydroxycarboxylate + FAD + H(+) = a 2-oxocarboxylate + FADH2

Left to rightBalance undeterminableRhea 82511

5,7-dibromo-indole-3-carbonitrile + 2,3,5-tribromoindole + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = aetokthonotoxin + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 H2O

Direction not assertedBalance undeterminableRhea 82519

5-bromo-L-tryptophan + H2O = 5-bromoindole + pyruvate + NH4(+)

Direction not assertedBalancedRhea 82523

5-bromoindole + bromide + FADH2 + O2 = 3,5-dibromoindole + FAD + 2 H2O

Direction not assertedBalancedRhea 82527

3,5-dibromoindole + bromide + FADH2 + O2 = 2,3,5-tribromoindole + FAD + 2 H2O

Direction not assertedBalancedRhea 82531

[sulfur-carrier protein]-C-terminal Gly-Gly-L-Cys + H2O = [sulfur-carrier protein]-C-terminal Gly-Gly + L-cysteine

Direction not assertedBalance undeterminableRhea 82535

[sulfur-carrier protein]-C-terminal Gly-Gly + hydrogen sulfide + ATP = [sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 82539

[sulfur-carrier protein]-C-terminal-Gly-aminoethanethioate + O-phospho-L-homoserine + H2O = [sulfur-carrier protein]-C-terminal Gly-Gly + L-homocysteine + phosphate

Direction not assertedBalance undeterminableRhea 82543

2 trans-resveratrol + O2 = 2 piceatannol

Direction not assertedBalancedRhea 82547

2 piceatannol + O2 = 2 piceatannolquinone + 2 H2O

Direction not assertedBalancedRhea 82551

UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H2O = UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioyl-D-alanine + D-alanine

Direction not assertedBalancedRhea 82555

K(+)(in) + L-cysteine(out) + 3 Na(+)(out) + H(+)(out) = K(+)(out) + L-cysteine(in) + 3 Na(+)(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 82559

an (R,S)-glycero-3-phospho-(3'-acyl-1'-glycerol) + a 1-acyl-sn-glycerol = a 3-acyl-sn-glycero-1-phospho-(3'-acyl-1'-sn-glycerol) + glycerol

Left to rightBalance undeterminableRhea 82563

3-lyso-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + 1-(9Z-octadecenoyl)-sn-glycerol = 3-(9Z-octadecenoyl)-sn-glycero-1-phospho-(3'-(9Z-octadecenoyl)-1'-sn-glycerol) + glycerol

Left to rightBalancedRhea 82567

3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5-triiodo-L-thyronine + AH2

Right to leftBalancedRhea 82571

3,3'-diiodo-L-thyronine + iodide + A + H(+) = 3,3',5'-triiodo-L-thyronine + AH2

Right to leftBalancedRhea 82575

10-carboxy-13-deoxycarminomycin + AH2 + O2 + H(+) = 10-hydroxy-13-deoxycarminomycin + A + CO2 + H2O

Direction not assertedBalancedRhea 82579

10-hydroxy-13-deoxycarminomycin + S-adenosyl-L-methionine = 10-hydroxy-13-deoxydaunorubicin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 82583

(S,S)-drim-8-en-11-yl diphosphate + D-mannitol = sporulositol A + diphosphate

Direction not assertedBalancedRhea 82587

3,4-dimethoxybenzoate + AH2 + O2 = vanillate + formaldehyde + A + H2O

Direction not assertedBalancedRhea 82591

3-hydroxy-4-methoxybenzoate + AH2 + O2 = 3,4-dihydroxybenzoate + formaldehyde + A + H2O

Direction not assertedBalancedRhea 82595

2 ATP = 5'-triphosphoadenylyl-(2'->5')-adenosine + diphosphate

Left to rightBalancedRhea 82599

a 5'-end N-acetyl-alpha-D-glucosamine-diphospho-uridyl-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + UDP-N-acetyl-alpha-D-glucosamine + H(+)

Left to rightBalance undeterminableRhea 82603

3,5-dimethylorsellinate + reduced [NADPH--hemoprotein reductase] + O2 = 4,6-dihydroxy-2-(hydroxymethyl)-3,5-dimethylbenzoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 82607

4,6-dihydroxy-2-(hydroxymethyl)-3,5-dimethylbenzoate + H(+) = 5,7-dihydroxy-4,6-dimethylphthalide + H2O

Direction not assertedBalancedRhea 82611

5,7-dihydroxy-4,6-dimethylphthalide + (2E,6E)-farnesyl diphosphate = (E,E)-farnesyl-5,7-dihydroxy-4,6-dimethylphthalide + diphosphate + H(+)

Direction not assertedBalancedRhea 82615

(E,E)-farnesyl-5,7-dihydroxy-4,6-dimethylphthalide + AH2 + O2 = (E,E)-epoxyfarnesyl-5,7-dihydroxy-4,6-dimethylphthalide + A + H2O

Direction not assertedBalancedRhea 82619

(E,E)-epoxyfarnesyl-5,7-dihydroxy-4,6-dimethylphthalide + H(+) = preandiloid A

Direction not assertedBalancedRhea 82623

preandiloid A + A = preandiloid B + AH2

Direction not assertedBalancedRhea 82627

preandiloid B + A = preandiloid C + AH2

Direction not assertedBalancedRhea 82631

Page 351 of 372