Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

1,701–1,750 of 18,558 reactions from Rhea

L-seryl-[tyrosine-3-monooxygenase] + ATP = O-phospho-L-seryl-[tyrosine-3-monooxygenase] + ADP + H(+)
Direction not assertedBalance undeterminableRhea 17133
prostaglandin H2 = thromboxane A2
Left to rightBalancedRhea 17137
oxaloacetate + glycine = glyoxylate + L-aspartate
Direction not assertedBalancedRhea 17141
2'-hydroxy-2,3-dihydrodaidzein + NADP(+) = 2'-hydroxydaidzein + NADPH + 2 H(+)
Direction not assertedBalancedRhea 17145
an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
ReversibleBalance undeterminableRhea 17149
CDP-D-glucose = CDP-4-dehydro-6-deoxy-D-glucose + H2O
Direction not assertedBalancedRhea 17153
creatine + ATP = N-phosphocreatine + ADP + H(+)

Left to rightBalancedRhea 17157

2,6-dioxo-6-phenylhexa-3-enoate + H2O = 2-oxopent-4-enoate + benzoate + H(+)

Direction not assertedBalancedRhea 17161

alpha-D-galactose 1-phosphate + dTTP + H(+) = dTDP-D-galactose + diphosphate

Direction not assertedBalancedRhea 17165

alpha-D-galactosamine 1-phosphate + acetyl-CoA = N-acetyl-alpha-D-galactosamine 1-phosphate + CoA + H(+)

Direction not assertedBalancedRhea 17169

glutathionylspermidine + H2O = spermidine + glutathione

Direction not assertedBalancedRhea 17173

octanoyl-CoA + (R)-carnitine = O-octanoyl-(R)-carnitine + CoA

Left to rightBalancedRhea 17177

a long-chain fatty aldehyde + FMNH2 + O2 = a long-chain fatty acid + hnu + FMN + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 17181

IMP + NH4(+) + NADP(+) = GMP + NADPH + 2 H(+)

Direction not assertedBalancedRhea 17185

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + phosphate

Left to rightBalance undeterminableRhea 17193

2 3-(4-hydroxyphenyl)pyruvate + O2 = 2 4-hydroxyphenylacetate + 2 CO2

Direction not assertedBalancedRhea 17197

2-dehydro-3-deoxy-L-arabinonate = 2,5-dioxopentanoate + H2O

Direction not assertedBalancedRhea 17201

quercetin 3-sulfate + 3'-phosphoadenylyl sulfate = quercetin 3,4'-bissulfate + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalancedRhea 17205

1,4,5,6-tetrahydro-6-oxonicotinate + 2 H2O = 2-formylglutarate + NH4(+)

Direction not assertedBalancedRhea 17209

UDP-N-acetyl-alpha-D-glucosamine = UDP-N-acetyl-alpha-D-mannosamine

Direction not assertedBalancedRhea 17213

dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O

Direction not assertedBalancedRhea 17221

1,4,5,6-tetrahydro-6-oxonicotinate + oxidized 2[4Fe-4S]-[ferredoxin] = 6-hydroxynicotinate + reduced 2[4Fe-4S]-[ferredoxin] + 2 H(+)

Direction not assertedBalance undeterminableRhea 17225

an aliphatic alcohol + acetyl-CoA = an acetyl ester + CoA

Direction not assertedBalance undeterminableRhea 17229

L-fucose = L-fuculose

Direction not assertedBalancedRhea 17233

FMN + ATP + H(+) = FAD + diphosphate

Left to rightBalancedRhea 17237

an alpha-amino acid ester + H2O = an alpha-amino acid + an alcohol + H(+)

Direction not assertedBalance undeterminableRhea 17241

3-hydroxyanthranilate + O2 = 6-imino-5-oxocyclohexa-1,3-dienecarboxylate + H2O2

Direction not assertedBalancedRhea 17245

2 Fe(2+) + H2O2 + 2 H2O = 2 iron(III) oxide-hydroxide + 6 H(+)

Direction not assertedBalancedRhea 17249

vinorine + reduced [NADPH--hemoprotein reductase] + O2 = vomilenine + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 17257

an aryl sulfate + H2O = a phenol + sulfate + H(+)

Direction not assertedBalance undeterminableRhea 17261

trans-aconitate = cis-aconitate

Direction not assertedBalancedRhea 17265

macrocin + S-adenosyl-L-methionine = tylosin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 17269

(4-hydroxyphenyl)acetaldehyde + NAD(+) + H2O = 4-hydroxyphenylacetate + NADH + 2 H(+)

Direction not assertedBalancedRhea 17273

6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O

Direction not assertedBalancedRhea 17277

(2S)-4-acetamido-2-aminobutanoate = L-ectoine + H2O

Direction not assertedBalancedRhea 17281

a 1,2-diacyl-sn-glycerol + UDP-alpha-D-glucose = a 1,2-diacyl-3-O-(beta-D-glucopyranosyl)-sn-glycerol + UDP + H(+)

Direction not assertedBalance undeterminableRhea 17285

beta-D-fructose 2,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate

Left to rightBalancedRhea 17289

precorrin-3A + NADH + O2 + 2 H(+) = precorrin-3B + NAD(+) + H2O

Direction not assertedBalancedRhea 17293

2 oxidized [2Fe-2S]-[ferredoxin] + 2-oxoglutarate + CoA = succinyl-CoA + 2 reduced [2Fe-2S]-[ferredoxin] + CO2 + H(+)

Direction not assertedBalance undeterminableRhea 17297

L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ATP = O-phospho-L-seryl-[3-methyl-2-oxobutanoate dehydrogenase] + ADP + H(+)

Left to rightBalance undeterminableRhea 17301

N(omega),N(omega)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline

Left to rightBalancedRhea 17305

a phenyl acetate + H2O = a phenol + acetate + H(+)

Direction not assertedBalance undeterminableRhea 17309

tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 17313

phytyl diphosphate + chlorophyllide a + H(+) = chlorophyll a + diphosphate

Direction not assertedBalancedRhea 17317

L-tryptophan + S-adenosyl-L-methionine = 2-methyl-L-tryptophan + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 17321

(S)-2,3,4,5-tetrahydrodipicolinate + succinyl-CoA + H2O = (S)-2-succinylamino-6-oxoheptanedioate + CoA

Direction not assertedBalancedRhea 17325

(1R,2S,4R)-borneol + NAD(+) = (1R,4R)-camphor + NADH + H(+)

Direction not assertedBalancedRhea 17329

zeatin + O-acetyl-L-serine = L-lupinate + acetate + H(+)

Direction not assertedBalancedRhea 17333

catechol + O2 = (2Z,4E)-2-hydroxy-6-oxohexa-2,4-dienoate + H(+)

Direction not assertedBalancedRhea 17337

1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + NADPH + H(+)

Direction not assertedBalancedRhea 17341

Page 35 of 372