Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

17,051–17,100 of 18,558 reactions from Rhea

(2-methylphenoxy)acetate + 2-oxoglutarate + O2 = 2-hydroxytoluene + glyoxylate + succinate + CO2
Direction not assertedBalancedRhea 80607
2,4-dichlorophenol + NADH + O2 + H(+) = 3,5-dichlorocatechol + NAD(+) + H2O
Direction not assertedBalancedRhea 80611
2-methyl-4-chlorophenol + NADH + O2 + H(+) = 5-chloro-3-methylcatechol + NAD(+) + H2O
Direction not assertedBalancedRhea 80615
4-chlorophenol + NADH + O2 + H(+) = 4-chlorocatechol + NAD(+) + H2O
Direction not assertedBalancedRhea 80619
2-chlorophenol + NADH + O2 + H(+) = 3-chlorocatechol + NAD(+) + H2O
Direction not assertedBalancedRhea 80623
5-chloro-3-methylcatechol + O2 = (2Z,4E)-4-chloro-2-methylmuconate + 2 H(+)
Direction not assertedBalancedRhea 80627
3-methylcatechol + O2 = (2Z,4Z)-2-methylmuconate + 2 H(+)

Direction not assertedBalancedRhea 80631

2 oxidized [4Fe-4S]-[ferredoxin] + taurine + H2O = aminoacetaldehyde + 2 reduced [4Fe-4S]-[ferredoxin] + sulfite + 3 H(+)

Direction not assertedBalance undeterminableRhea 80635

aminoacetaldehyde + 2 oxidized [4Fe-4S]-[ferredoxin] + H2O = 2 reduced [4Fe-4S]-[ferredoxin] + glycine + 3 H(+)

Direction not assertedBalance undeterminableRhea 80639

an aliphatic sulfonate + 4 oxidized [4Fe-4S]-[ferredoxin] + 2 H2O = 4 reduced [4Fe-4S]-[ferredoxin] + a carboxylate + sulfite + 6 H(+)

Direction not assertedBalance undeterminableRhea 80643

an aliphatic sulfonate + 2 oxidized [4Fe-4S]-[ferredoxin] + H2O = 2 reduced [4Fe-4S]-[ferredoxin] + an aldehyde + sulfite + 3 H(+)

Direction not assertedBalance undeterminableRhea 80647

2 oxidized [4Fe-4S]-[ferredoxin] + an aldehyde + H2O = 2 reduced [4Fe-4S]-[ferredoxin] + a carboxylate + 3 H(+)

Direction not assertedBalance undeterminableRhea 80651

oripavine + S-adenosyl-L-methionine = thebaine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 80655

cephaeline + S-adenosyl-L-methionine = emetine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 80659

deacetylisoipecoside + S-adenosyl-L-methionine = 6-O-methyldeacetylisoipecoside + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 80663

7-O-methyldeacetylisoipecoside + S-adenosyl-L-methionine = 6,7-O,O-dimethyldeacetylisoipecoside + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 80667

4-methylmuconolactone = (2Z,4Z)-3-methylmuconate + H(+)

Direction not assertedBalancedRhea 80671

4-methylcatechol + O2 = (2Z,4Z)-3-methylmuconate + 2 H(+)

Direction not assertedBalancedRhea 80675

5-methylsalicylate + NADH + O2 + 2 H(+) = 4-methylcatechol + CO2 + NAD(+) + H2O

Direction not assertedBalancedRhea 80679

4-methylsalicylate + NADH + O2 + 2 H(+) = 4-methylcatechol + CO2 + NAD(+) + H2O

Direction not assertedBalancedRhea 80683

3-methylsalicylate + NADH + O2 + 2 H(+) = 3-methylcatechol + CO2 + NAD(+) + H2O

Direction not assertedBalancedRhea 80687

isococlaurine + S-adenosyl-L-methionine = 7-O-methylcoclaurine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 80691

(S)-norprotosinomenine + S-adenosyl-L-methionine = (S)-6-O-methylnorprotosinomenine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 80695

(R)-norprotosinomenine + S-adenosyl-L-methionine = (R)-6-O-methylnorprotosinomenine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 80699

5-chlorosalicylate + NADH + O2 + 2 H(+) = 4-chlorocatechol + CO2 + NAD(+) + H2O

Direction not assertedBalancedRhea 80703

4-chlorosalicylate + NADH + O2 + 2 H(+) = 4-chlorocatechol + CO2 + NAD(+) + H2O

Direction not assertedBalancedRhea 80707

3-chlorosalicylate + NADH + O2 + 2 H(+) = 3-chlorocatechol + CO2 + NAD(+) + H2O

Direction not assertedBalancedRhea 80711

2-(2-chloro-2,5-dihydro-4-methyl-5-oxofuryl)acetate = (2Z,4E)-4-chloro-2-methylmuconate + H(+)

Direction not assertedBalancedRhea 80715

a di-trans,poly-cis-polyprenol + NAD(+) = a di-trans,poly-cis-polyprenal + NADH + H(+)

Left to rightBalance undeterminableRhea 80719

a di-trans,poly-cis-polyprenol + NADP(+) = a di-trans,poly-cis-polyprenal + NADPH + H(+)

Left to rightBalance undeterminableRhea 80723

a di-trans,poly-cis-dolichal + NADP(+) = a di-trans,poly-cis-polyprenal + NADPH + H(+)

Right to leftBalance undeterminableRhea 80727

a di-trans,poly-cis-dolichol + NADP(+) = a di-trans,poly-cis-dolichal + NADPH + H(+)

Right to leftBalance undeterminableRhea 80731

a di-trans,poly-cis-dolichol + NAD(+) = a di-trans,poly-cis-dolichal + NADH + H(+)

Right to leftBalance undeterminableRhea 80735

2-(2-chloro-2,5-dihydro-4-methyl-5-oxofuryl)acetate = cis-2-methyl-4-carboxylatomethylenebut-2-en-1,4-olide + chloride + H(+)

Direction not assertedBalancedRhea 80739

2-(2-chloro-2,5-dihydro-4-methyl-5-oxofuryl)acetate = trans-2-methyl-4-carboxylatomethylenebut-2-en-1,4-olide + chloride + H(+)

Direction not assertedBalancedRhea 80743

2-(2,4-dichloro-5-oxo-2,5-dihydrofuryl)acetate = trans-2-chloro-4-carboxymethylenebut-2-en-1,4-olide + chloride + H(+)

Direction not assertedBalancedRhea 80747

a neolactoside nLc6Cer(d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a neolactoside VI(3)-alpha-NeuNAc-nLc6Cer(d18:1(4E)) + CMP + H(+)

Left to rightBalance undeterminableRhea 80751

a neolactoside nLc6Cer + CMP-N-acetyl-beta-neuraminate = a neolactoside VI(3)-alpha-NeuNAc-nLc6Cer + CMP + H(+)

Direction not assertedBalance undeterminableRhea 80755

bis(2-hydroxyethyl) terephthalate + H2O = 4-[(2-hydroxyethoxy)carbonyl]benzoate + ethylene glycol + H(+)

Direction not assertedBalancedRhea 80759

an Ac-O-9-sialoglycoconjugate + H2O = a sialoglycoconjugate + acetate + H(+)

Left to rightBalance undeterminableRhea 80763

an alpha-ketoester + NADPH + H(+) = an (R)-hydroxy ester + NADP(+)

Direction not assertedBalance undeterminableRhea 80767

L-tryptophan + S-adenosyl-L-methionine = N(alpha)-methyl-L-tryptophan + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 80771

(S)-epichlorohydrin + H2O = (S)-3-chloro-1,2-propanediol

Direction not assertedBalancedRhea 80779

(R)-epichlorohydrin + H2O = (R)-3-chloro-1,2-propanediol

Direction not assertedBalancedRhea 80783

1,2-epoxy-9-decene + H2O = dec-9-ene-1,2-diol

Direction not assertedBalancedRhea 80787

(R)-styrene oxide + H2O = (R)-styrene glycol

Direction not assertedBalancedRhea 80791

(S)-styrene oxide + H2O = (S)-styrene glycol

Direction not assertedBalancedRhea 80795

3,4-epoxy-1-cyclohexene + H2O = cyclohex-3-ene-1,2-diol

Direction not assertedBalancedRhea 80799

GDGT-0 + AH2 + 2 S-adenosyl-L-methionine = GMGT-0 + 2 5'-deoxyadenosine + 2 L-methionine + A + 2 H(+)

Direction not assertedBalancedRhea 80803

4-methyl-2-oxopentanoate + S-adenosyl-L-methionine = (3R)-3,4-dimethyl-2-oxopentanoate + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 80807

Page 342 of 372