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ReactionsRhea and Human-GEM, by subsystem
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Reference

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

16,951–17,000 of 18,558 reactions from Rhea

cyclo(L-arginyl-tyrosyl) + reduced [NADPH--hemoprotein reductase] + O2 = cyclo(L-arginyl-L-dehydrotyrosyl) + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)
Direction not assertedBalance undeterminableRhea 80207
cyclo(L-arginyl-L-dehydrotyrosyl) + AH2 + O2 = cyclo(L-arginyl-(Z)-dehydro-3,4-dihydroxytyrosyl) + A + H2O
Direction not assertedBalancedRhea 80211
(S)-2,3-epoxysqualene = motiol
Direction not assertedBalancedRhea 80215
motiol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4beta-carboxyl motiol + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)
Direction not assertedBalance undeterminableRhea 80219
4beta-carboxyl motiol + reduced [NADPH--hemoprotein reductase] + O2 = 2alpha-hydroxyl, 4beta-carboxyl motiol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Direction not assertedBalance undeterminableRhea 80223
2alpha-hydroxyl, 4beta-carboxyl motiol + 4 reduced [NADPH--hemoprotein reductase] + 4 O2 = polytolypin + 4 oxidized [NADPH--hemoprotein reductase] + 5 H2O + 5 H(+)

? Direction not asserted

Balance undeterminable

Rhea 80227

4beta-carboxyl motiol + 4 reduced [NADPH--hemoprotein reductase] + 4 O2 = 2-deoxypolytolypin + 4 oxidized [NADPH--hemoprotein reductase] + 5 H2O + 5 H(+)

Direction not assertedBalance undeterminableRhea 80231

2-deoxypolytolypin + reduced [NADPH--hemoprotein reductase] + O2 = polytolypin + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 80235

1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-ethanolamine = 1-O-hexadecyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)

Direction not assertedBalancedRhea 80239

1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycerol + CDP-ethanolamine = 1-O-hexadecyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CMP + H(+)

Direction not assertedBalancedRhea 80243

1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CDP-ethanolamine = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CMP + H(+)

Direction not assertedBalancedRhea 80247

cyclo(L-arginyl-(Z)-dehydro-3,4-dihydroxytyrosyl) + O-acetyl-L-homoserine = cyclo(L-arginyl-(Z)-dehydro-4-O-homoseryl-tyrosyl) + acetate + H(+)

Direction not assertedBalancedRhea 80251

cyclo(L-arginyl-(Z)-dehydro-4-O-homoseryl-tyrosyl) + citrate + ATP = NK13650 B + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 80255

NK13650 B + S-adenosyl-L-methionine = NK13650 D + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 80259

NK13650 D + L-aspartate + ATP = NK13650 C + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 80263

NK13650 B + L-aspartate + ATP = NK13650 A + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 80267

(S)-lactate + ATP + H(+) = (S)-lactoyl-AMP + diphosphate

Left to rightBalancedRhea 80271

(S)-lactoyl-AMP + L-lysyl-[protein] = N(6)-[(S)-lactoyl]-L-lysyl-[protein] + AMP + 2 H(+)

Left to rightBalance undeterminableRhea 80275

tirucalla-7,24-dien-3beta-ol + 2 reduced [NADPH--hemoprotein reductase] + 2 O2 = dihydroniloticin + 2 oxidized [NADPH--hemoprotein reductase] + 2 H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 80279

dihydroniloticin + 2 reduced [NADPH--hemoprotein reductase] + 2 O2 = melianol + 2 oxidized [NADPH--hemoprotein reductase] + 3 H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 80283

N(6)-[(S)-lactoyl]-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-(S)-lactoyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]

Left to rightBalance undeterminableRhea 80287

melianol + reduced [NADPH--hemoprotein reductase] + O2 = 7,8-epoxymelianol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 80291

7,8-epoxymelianol = isomeliandiol

Direction not assertedBalancedRhea 80295

7,8-epoxymelianol = protoglabretal

Direction not assertedBalancedRhea 80299

isomeliandiol + acetyl-CoA = 21-O-acetyl-isomeliandiol + CoA

Direction not assertedBalancedRhea 80303

21-O-acetyl-isomeliandiol + A = (21S)-21-acetoxyl-apo-melianone + AH2

Direction not assertedBalancedRhea 80307

(21S)-21-acetoxyl-apo-melianone + reduced [NADPH--hemoprotein reductase] + O2 = luvungin A + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 80311

(21S)-21-acetoxyl-apo-melianone + reduced [NADPH--hemoprotein reductase] + O2 = (21S)-21-acetyl-1-hydroxy-apo-melianone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 80315

luvungin A + reduced [NADPH--hemoprotein reductase] + O2 = (1S)-1-hydroxy-luvungin A + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 80319

(1S)-1-hydroxy-luvungin A + acetyl-CoA = (1S)-1-acetoxy-luvungin A + CoA

Direction not assertedBalancedRhea 80323

(21S)-21-acetyl-1-hydroxy-apo-melianone + acetyl-CoA = epi-neemfruitin B + acetate + CoA + H(+)

Direction not assertedBalancedRhea 80327

(1S)-1-acetoxy-luvungin A + acetyl-CoA = (1S)-1,7-diacetoxy-luvungin A + CoA

Direction not assertedBalancedRhea 80331

epi-neemfruitin B + acetyl-CoA = 7-acetyl-epi-neemfruitin B + CoA

Direction not assertedBalancedRhea 80335

(1S)-1,7-diacetoxy-luvungin A + AH2 + H2O = (1R,2R,3S,8R,10R,11R,15S,16S)-3-(acetyloxy)-15-[(4R)-4-[(2S)-3,3-dimethyloxiran-2-yl]-1,4-dihydroxybutan-2-yl]-2,7,7,11,16-pentamethyl-5-oxo-6-oxatetracyclo[9.7.0.0(2,8).0(12,16)]octadec-12-en-10-yl acetate + acetate + A + H(+)

Direction not assertedBalancedRhea 80339

7-acetyl-epi-neemfruitin B + AH2 + H2O = (1S,3bR,4R,5aR,9aR,9bR,11aS)-1-[(4R)-5-[(2S)-3,3-dimethyloxiran-2-yl]-1,4-dihydroxybutan-2-yl]-3b,6,6,9a,11a-pentamethyl-7-oxo-1H,2H,3bH,4H,5H,5aH,6H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-4-yl acetate + acetate + A + H(+)

Direction not assertedBalancedRhea 80343

(1R,2R,3S,8R,10R,11R,15S,16S)-3-(acetyloxy)-15-[(4R)-4-[(2S)-3,3-dimethyloxiran-2-yl]-1,4-dihydroxybutan-2-yl]-2,7,7,11,16-pentamethyl-5-oxo-6-oxatetracyclo[9.7.0.0(2,8).0(12,16)]octadec-12-en-10-yl acetate + reduced [NADPH--hemoprotein reductase] + O2 = (1R,2R,3S,8R,10R,11R,15S,16S)-3-(acetyloxy)-15-(1-hydroxy-4-oxobutan-2-yl)-2,7,7,11,16-pentamethyl-5-oxo-6-oxatetracyclo[9.7.0.0(2,8).0(12,16)]octadec-12-en-10-yl acetate + 2-methylpropanoate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 80347

(1S,3bR,4R,5aR,9aR,9bR,11aS)-1-[(4R)-5-[(2S)-3,3-dimethyloxiran-2-yl]-1,4-dihydroxybutan-2-yl]-3b,6,6,9a,11a-pentamethyl-7-oxo-1H,2H,3bH,4H,5H,5aH,6H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-4-yl acetate + reduced [NADPH--hemoprotein reductase] + O2 = (1S,3bR,4R,5aR,9aR,9bR,11aS)-1-(1-hydroxy-4-oxobutan-2-yl)-3b,6,6,9a,11a-pentamethyl-7-oxo-1H,2H,3bH,4H,5H,5aH,6H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-4-yl acetate + 2-methylpropanoate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 80351

(1R,2R,3S,8R,10R,11R,15S,16S)-3-(acetyloxy)-15-(1-hydroxy-4-oxobutan-2-yl)-2,7,7,11,16-pentamethyl-5-oxo-6-oxatetracyclo[9.7.0.0(2,8).0(12,16)]octadec-12-en-10-yl acetate + 2-oxoglutarate + O2 = kihadalactone A + succinate + CO2 + 2 H2O

Direction not assertedBalancedRhea 80355

4-nitrotoluene + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = 4-nitrobenzyl alcohol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 80359

4-nitrobenzaldehyde + NAD(+) + H2O = 4-nitrobenzoate + NADH + 2 H(+)

Direction not assertedBalancedRhea 80363

3-nitrobenzaldehyde + NAD(+) + H2O = 3-nitrobenzoate + NADH + 2 H(+)

Direction not assertedBalancedRhea 80367

4-methylbenzaldehyde + NAD(+) + H2O = 4-methylbenzoate + NADH + 2 H(+)

Direction not assertedBalancedRhea 80371

3-methylbenzaldehyde + NAD(+) + H2O = 3-methylbenzoate + NADH + 2 H(+)

Direction not assertedBalancedRhea 80375

4-nitrobenzyl alcohol + O2 = 4-nitrobenzaldehyde + H2O2

Direction not assertedBalancedRhea 80379

benzyl alcohol + O2 = benzaldehyde + H2O2

Direction not assertedBalancedRhea 80383

(1S,3bR,4R,5aR,9aR,9bR,11aS)-1-(1-hydroxy-4-oxobutan-2-yl)-3b,6,6,9a,11a-pentamethyl-7-oxo-1H,2H,3bH,4H,5H,5aH,6H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-4-yl acetate + 2-oxoglutarate + O2 = azadirone + succinate + CO2 + 2 H2O

Direction not assertedBalancedRhea 80387

(2E)-geranyl diphosphate = camphene + diphosphate

Direction not assertedBalancedRhea 80391

(2E)-geranyl diphosphate = isoterpinolene + diphosphate

Direction not assertedBalancedRhea 80395

(2E,6E)-farnesyl diphosphate + H2O = palustrol + diphosphate

Direction not assertedBalancedRhea 80399

(2E,6E)-farnesyl diphosphate + H2O = selina-6-en-4-ol + diphosphate

Direction not assertedBalancedRhea 80403

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