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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
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Chemistry

Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

1,651–1,700 of 18,558 reactions from Rhea

(E)-caffeoyl-CoA + S-adenosyl-L-methionine = (E)-feruloyl-CoA + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalancedRhea 16925
2 benzoyl-CoA + L-ornithine = N(2),N(5)-dibenzoyl-L-ornithine + 2 CoA + 2 H(+)
Direction not assertedBalancedRhea 16929
1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH4(+)
Direction not assertedBalancedRhea 16933
a 1-O-alkyl-sn-glycerol + ATP = a 1-O-alkyl-sn-glycero-3-phosphate + ADP + H(+)
Left to rightBalance undeterminableRhea 16937
N-acetylindoxyl + O2 = N-acetylisatin + H2O
Direction not assertedBalancedRhea 16941
N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)
Direction not assertedBalance undeterminableRhea 16945

myo-inositol + NAD(+) = scyllo-inosose + NADH + H(+)

Direction not assertedBalancedRhea 16949

N(2)-succinyl-L-ornithine + 2-oxoglutarate = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate

Direction not assertedBalancedRhea 16953

3',5'-cyclic GMP + H2O = GMP + H(+)

Left to rightBalancedRhea 16957

epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L-lysine

Direction not assertedBalancedRhea 16961

(2E)-geranyl diphosphate = beta-myrcene + diphosphate

Direction not assertedBalancedRhea 16965

dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose

Direction not assertedBalancedRhea 16969

2-hydroxypyridine + AH2 + O2 = 2,5-dihydroxypyridine + A + H2O

Direction not assertedBalancedRhea 16973

coenzyme M + acetoacetate + NADP(+) = 2-oxopropyl-coenzyme M + CO2 + NADPH

Direction not assertedBalancedRhea 16977

3-oxoadipate + NAD(+) = maleylacetate + NADH + H(+)

Direction not assertedBalancedRhea 16981

3-oxoadipate + NADP(+) = maleylacetate + NADPH + H(+)

Direction not assertedBalancedRhea 16985

1D-myo-inositol hexakisphosphate + H2O = 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate

Left to rightBalancedRhea 16989

S-disulfanyl-L-cysteinyl-[SoxY protein] + 6 Fe(III)-[cytochrome c] + 3 H2O = S-sulfosulfanyl-L-cysteinyl-[SoxY protein] + 6 Fe(II)-[cytochrome c] + 7 H(+)

Direction not assertedBalance undeterminableRhea 16993

5alpha-cholane-3alpha,7alpha,12alpha,24-tetrol + 3'-phosphoadenylyl sulfate = 3alpha,7alpha,12alpha-trihydroxy-5alpha-cholan-24-yl sulfate + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalancedRhea 16997

amidinoproclavaminate + H2O = proclavaminate + urea

Direction not assertedBalancedRhea 17001

D-glucuronate + ATP = 1-phospho-alpha-D-glucuronate + ADP + H(+)

Direction not assertedBalancedRhea 17005

2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 17009

phosphoenolpyruvate + H(+) = 3-phosphonopyruvate

Direction not assertedBalancedRhea 17013

N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + acetyl-CoA = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CoA

Right to leftBalance undeterminableRhea 17017

(2-aminoethyl)phosphonate + pyruvate = phosphonoacetaldehyde + L-alanine

Direction not assertedBalancedRhea 17021

xylitol + NADP(+) = L-xylulose + NADPH + H(+)

Right to leftBalancedRhea 17025

(S)-allantoin + H2O = allantoate + H(+)

Direction not assertedBalancedRhea 17029

(2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+) = biphenyl-2,3-diol + NADH + H(+)

Direction not assertedBalancedRhea 17033

indole-3-ethanol + NADP(+) = indole-3-acetaldehyde + NADPH + H(+)

Direction not assertedBalancedRhea 17037

adenosine 5'-phosphosulfate + H2O = sulfate + AMP + 2 H(+)

Direction not assertedBalancedRhea 17041

3-demethylubiquinol-9 + S-adenosyl-L-methionine = ubiquinol-9 + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 17049

D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate

ReversibleBalancedRhea 17053

a 2-acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a fatty acyl-[ACP] = a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + holo-[ACP]

Direction not assertedBalance undeterminableRhea 17057

phenol + NADPH + O2 + H(+) = catechol + NADP(+) + H2O

Direction not assertedBalancedRhea 17061

(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)

Direction not assertedBalancedRhea 17065

cortisol + acetyl-CoA = cortisol 21-acetate + CoA

Direction not assertedBalancedRhea 17073

N,N-dimethylglycine + O2 + H2O = sarcosine + formaldehyde + H2O2

Direction not assertedBalancedRhea 17077

(E)-isoeugenol + S-adenosyl-L-methionine = (E)-isomethyleugenol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 17081

4-pyridoxate + A = 5-formyl-3-hydroxy-2-methylpyridine-4-carboxylate + AH2

Direction not assertedBalancedRhea 17085

2-dehydro-3-deoxy-6-phospho-D-gluconate = D-glyceraldehyde 3-phosphate + pyruvate

Direction not assertedBalancedRhea 17089

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = 1D-myo-inositol 1,2-cyclic phosphate + a 1,2-diacyl-sn-glycerol

Direction not assertedBalance undeterminableRhea 17093

3-phenylpyruvate = enol-phenylpyruvate

Direction not assertedBalancedRhea 17097

an O-acyl-(R)-carnitine + H2O = (R)-carnitine + a fatty acid + H(+)

Direction not assertedBalance undeterminableRhea 17101

malonyl-[ACP] + S-adenosyl-L-methionine = malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine

Direction not assertedBalance undeterminableRhea 17105

N-methylnicotinate + FMNH2 + O2 = (Z)-2-((N-methylformamido)methylene)-5-hydroxybutanolactone + FMN + H(+)

Direction not assertedBalancedRhea 17109

L-serine-phosphoethanolamine + H2O = phosphoethanolamine + L-serine + H(+)

Direction not assertedBalancedRhea 17113

methylamine + L-glutamate + ATP = N(5)-methyl-L-glutamine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 17117

carbamoyl phosphate + L-lysine = L-homocitrulline + phosphate + H(+)

Direction not assertedBalancedRhea 17121

N-(4-carboxy-4-oxobutanoyl)-L-ethylglycylglycine + H2O = N-(2-aminobutanoyl)glycine + 2-oxoglutarate

Direction not assertedBalancedRhea 17125

N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)

Left to rightBalancedRhea 17129

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