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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

16,751–16,800 of 18,558 reactions from Rhea

L-lysyl-glycine(out) = L-lysyl-glycine(in)
Direction not assertedBalancedTransportRhea 79407
L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)
Direction not assertedBalancedTransportRhea 79411
L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)
Direction not assertedBalancedTransportRhea 79415
myo-inositol + NAD(+) = myo-inosose-5 + NADH + H(+)
Direction not assertedBalancedRhea 79419
thiamine + UTP = thiamine diphosphate + UMP + H(+)
Left to rightBalancedRhea 79423
(E)-ferulate + H2O = 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoate
Direction not assertedBalancedRhea 79427
1-(1Z-octadecenyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine = 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z- eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + 1-octadecanoyl-sn-glycero-3-phosphocholine

Left to rightBalancedRhea 79431

a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + a 1-acyl-sn-glycero-3-phosphocholine

Direction not assertedBalance undeterminableRhea 79435

3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoate = vanillin + acetate

Direction not assertedBalancedRhea 79439

4-O-beta-D-glucosyl-trans-ferulate + H2O = 3-hydroxy-3-(4-O-beta-D-glucosyl-3-methoxyphenyl)propanoate

Direction not assertedBalancedRhea 79443

3-hydroxy-3-(4-O-beta-D-glucosyl-3-methoxyphenyl)propanoate = 4-O-beta-D-glucosyl-vanillin + acetate

Direction not assertedBalancedRhea 79447

(E)-4-coumarate + H2O = 3-hydroxy-3-(4-hydroxyphenyl)propanoate

Direction not assertedBalancedRhea 79451

3-hydroxy-3-(4-hydroxyphenyl)propanoate = 4-hydroxybenzaldehyde + acetate

Direction not assertedBalancedRhea 79455

(2E,6E,10E)-geranylgeranyl diphosphate = sobralene + diphosphate

Direction not assertedBalancedRhea 79459

(2Z,6E)-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate

Direction not assertedBalancedRhea 79463

luteolin + S-adenosyl-L-methionine = diosmetin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 79467

citrate(out) + 2 Na(+)(out) = citrate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 79471

(S)-lactate(in) + (S)-malate(out) = (S)-lactate(out) + (S)-malate(in)

Direction not assertedBalancedTransportRhea 79475

(R)-lactate(in) + (S)-malate(out) = (R)-lactate(out) + (S)-malate(in)

Direction not assertedBalancedTransportRhea 79479

glycolate(in) + (S)-malate(out) = glycolate(out) + (S)-malate(in)

Direction not assertedBalancedTransportRhea 79483

(S)-lactate(in) + citrate(out) = (S)-lactate(out) + citrate(in)

Direction not assertedBalancedTransportRhea 79487

(R)-lactate(in) + citrate(out) = (R)-lactate(out) + citrate(in)

Direction not assertedBalancedTransportRhea 79491

a ganglioside GD3 + acetyl-CoA = a ganglioside Ac-O-7-GD3 + CoA

Direction not assertedBalance undeterminableRhea 79495

a ganglioside GD3 (d18:1(4E)) + acetyl-CoA = a ganglioside Ac-O-7-GD3(d18:1(4E)) + CoA

Left to rightBalance undeterminableRhea 79499

3-(3,4-dihydroxyphenyl)propanoate + NAD(+) = (E)-caffeate + NADH + H(+)

Direction not assertedBalancedRhea 79503

phloretate + NAD(+) = (E)-4-coumarate + NADH + H(+)

Direction not assertedBalancedRhea 79507

dihydroferulate + NAD(+) = (E)-ferulate + NADH + H(+)

Direction not assertedBalancedRhea 79511

a ganglioside Ac-O-7-GD3 = a ganglioside Ac-O-8-GD3

Direction not assertedBalance undeterminableRhea 79515

a ganglioside Ac-O-7-GD3(d18:1(4E)) = a ganglioside Ac-O-8-GD3(d18:1(4E))

Direction not assertedBalance undeterminableRhea 79519

a ganglioside Ac-O-8-GD3 = a ganglioside Ac-O-9-GD3

Direction not assertedBalance undeterminableRhea 79523

a ganglioside Ac-O-8-GD3(d18:1(4E)) = a ganglioside Ac-O-9-GD3(d18:1(4E))

Direction not assertedBalance undeterminableRhea 79527

keto-D-fructose 6-phosphate + CTP + H(+) = CDP-6-keto-D-fructose + diphosphate

Direction not assertedBalancedRhea 79531

CDP-6-D-glucitol + NADP(+) = CDP-6-keto-D-fructose + NADPH + H(+)

Direction not assertedBalancedRhea 79535

2 Fe(III)-[cytochrome c] + formaldehyde + H2O = 2 Fe(II)-[cytochrome c] + formate + 3 H(+)

Direction not assertedBalance undeterminableRhea 79539

(S)-2-hydroxyglutarate(in) + (S)-malate(out) = (S)-2-hydroxyglutarate(out) + (S)-malate(in)

Direction not assertedBalancedTransportRhea 79543

cadaverine + acetyl-CoA = N-acetylcadaverine + CoA + H(+)

Direction not assertedBalancedRhea 79547

sym-homospermidine + acetyl-CoA = N(1)-acetyl-sym-homospermidine + CoA + H(+)

Direction not assertedBalancedRhea 79551

CMP-N-acetyl-beta-neuraminate + acetyl-CoA = CMP-N-acetyl-7-O-acetyl-beta-neuraminate + CoA

Left to rightBalancedRhea 79555

CMP-N-acetyl-7-O-acetyl-beta-neuraminate = CMP-N-acetyl-8-O-acetyl-beta-neuraminate

Direction not assertedBalancedRhea 79559

CMP-N-acetyl-8-O-acetyl-beta-neuraminate = CMP-N-acetyl-9-O-acetyl-beta-neuraminate

Direction not assertedBalancedRhea 79563

guanidine + H2O = urea + NH4(+)

Direction not assertedBalancedRhea 79567

L-arginine + ADP + phosphate + H(+) = L-citrulline + NH4(+) + ATP

Direction not assertedBalancedRhea 79571

a ganglioside Ac-O-9-GD3(d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside Ac-O-9-GD2(d18:1(4E)) + UDP + H(+)

Direction not assertedBalance undeterminableRhea 79575

a ganglioside Ac-O-9-GD3 + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside Ac-O-9-GD2 + UDP + H(+)

Direction not assertedBalance undeterminableRhea 79579

a ganglioside GT3 + acetyl-CoA = a ganglioside Ac-O-7-GT3 + CoA

Direction not assertedBalance undeterminableRhea 79583

3,17-didehydrostemmadenine = 17-dehydropreakuammicine

Direction not assertedBalancedRhea 79587

17-dehydropreakuammicine + H2O = 17-dehydropreakuammicine hydrate

Direction not assertedBalancedRhea 79591

17-dehydropreakuammicine hydrate = akuammicine + formate + H(+)

Direction not assertedBalancedRhea 79595

norajmaline + S-adenosyl-L-methionine = ajmaline + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 79599

4-methylnorajmaline + S-adenosyl-L-methionine = 4-methylajmaline + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 79603

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