Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

16,651–16,700 of 18,558 reactions from Rhea

3-amino-4-hydroxybenzoate + nitrite + ATP + H(+) = 3-diazo-4-hydroxybenzoate + AMP + diphosphate + H2O
Direction not assertedBalancedRhea 79007
ent-copalyl diphosphate = ent-beyerene + diphosphate
Direction not assertedBalancedRhea 79011
an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol(in) = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol(out)
Direction not assertedBalance undeterminableTransportRhea 79015
N(1)-methyladenosine(58) in tRNA + 2-oxoglutarate + O2 = adenosine(58) in tRNA + formaldehyde + succinate + CO2
Direction not assertedBalancedRhea 79019
a beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1->6)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)
Left to rightBalance undeterminableRhea 79023
an alpha-D-Man-(1->6)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)

Left to rightBalance undeterminableRhea 79027

adenylyl MoO3-molybdopterin cofactor = adenylyl MoO2(OH)-molybdopterin cofactor

Direction not assertedBalancedRhea 79031

adenylyl MoO2(OH)-molybdopterin cofactor + H2O = Mo-molybdopterin + AMP + 2 H(+)

Direction not assertedBalancedRhea 79035

S-methyl-(E)-thiourocanate + H2O = S-methyl-thiohydantoin-5-propanoate

Direction not assertedBalancedRhea 79039

ergothioneine (thione form) + H(+) = ergothioneine

Direction not assertedBalancedRhea 79043

cordycepin + H2O + H(+) = 3'-deoxyinosine + NH4(+)

Left to rightBalancedRhea 79047

(3S)-hydroxy-3-methylglutaryl-[ACP] = 4-carboxy-3-methylbut-(2E)-enoyl-[ACP] + H2O

Direction not assertedBalance undeterminableRhea 79051

urobilinogen + 4 A = (4Z,15Z)-bilirubin IXalpha + 4 AH2

Direction not assertedBalancedRhea 79055

4-carboxy-3-methylbut-(2E)-enoyl-[ACP] + H(+) = 3-methylbut-(2E)-enoyl-[ACP] + CO2

Direction not assertedBalance undeterminableRhea 79059

urobilinogen + 2 A = (4Z,15Z)-mesobilirubin IXalpha + 2 AH2

Direction not assertedBalancedRhea 79063

(4Z,15Z)-bilirubin IXalpha + UDP-alpha-D-glucuronate = (4Z,15Z)-bilirubin IXalpha C8-beta-D-glucuronoside + UDP

Left to rightBalancedRhea 79067

(4Z,15Z)-bilirubin IXalpha C8-beta-D-glucuronoside + UDP-alpha-D-glucuronate = (4Z,15Z)-bilirubin IXalpha C8,C12-beta-D-bisglucuronoside + UDP

Left to rightBalancedRhea 79071

(4Z,15Z)-bilirubin IXalpha C12-beta-D-glucuronoside + UDP-alpha-D-glucuronate = (4Z,15Z)-bilirubin IXalpha C8,C12-beta-D-bisglucuronoside + UDP

Left to rightBalancedRhea 79075

cyclohexane-1-carboxylate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = trans-4-hydroxycyclohexane-1-carboxylate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 79079

(3R)-3-methyl-D-ornithyl-N(6)-L-lysine + NAD(+) = L-pyrrolysine + NH4(+) + NADH + 2 H(+)

Direction not assertedBalancedRhea 79083

an L-alpha-amino acid + cholate = an N-choloyl-L-alpha-amino acid + H2O

Direction not assertedBalance undeterminableRhea 79087

an L-alpha-amino acid + taurocholate = an N-choloyl-L-alpha-amino acid + taurine

Direction not assertedBalance undeterminableRhea 79091

glycocholate + an L-alpha-amino acid = an N-choloyl-L-alpha-amino acid + glycine

Direction not assertedBalance undeterminableRhea 79095

cholate + L-histidine = L-histidocholate + H2O

Direction not assertedBalancedRhea 79099

taurocholate + L-histidine = L-histidocholate + taurine

Direction not assertedBalancedRhea 79103

glycocholate + L-histidine = L-histidocholate + glycine

Direction not assertedBalancedRhea 79107

cholate + L-arginine = L-arginocholate + H2O

Direction not assertedBalancedRhea 79111

taurocholate + L-arginine = L-arginocholate + taurine

Direction not assertedBalancedRhea 79115

glycocholate + L-arginine = L-arginocholate + glycine

Direction not assertedBalancedRhea 79119

cholate + L-phenylalanine = L-phenylalanocholate + H2O

Direction not assertedBalancedRhea 79123

taurocholate + L-phenylalanine = L-phenylalanocholate + taurine

Direction not assertedBalancedRhea 79127

cholate + L-alanine = L-alanocholate + H2O

Direction not assertedBalancedRhea 79131

taurocholate + L-alanine = L-alanocholate + taurine

Direction not assertedBalancedRhea 79135

cholate + L-serine = L-serocholate + H2O

Direction not assertedBalancedRhea 79139

taurocholate + L-serine = L-serocholate + taurine

Direction not assertedBalancedRhea 79143

cis-4-hydroxycyclohexane-1-carboxylate + NAD(+) = 4-oxocyclohexane-1-carboxylate + NADH + H(+)

Direction not assertedBalancedRhea 79147

4-oxocyclohexane-1-carboxylate + O2 = 4-oxocyclohex-2-ene-1-carboxylate + H2O2

Direction not assertedBalancedRhea 79151

(4Z,15Z)-bilirubin IXalpha C12-beta-D-glucuronoside(in) + ATP + H2O = (4Z,15Z)-bilirubin IXalpha C12-beta-D-glucuronoside(out) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 79155

4-oxocyclohex-2-ene-1-carboxylate + NAD(+) = 4-oxocyclohexa-2,5-diene-1-carboxylate + NADH + H(+)

Direction not assertedBalancedRhea 79159

4-oxocyclohexa-2,5-diene-1-carboxylate = 4-hydroxybenzoate

Direction not assertedBalancedRhea 79163

4alpha,5beta-5,20-epoxytax-11-ene-4-ol + reduced [NADPH--hemoprotein reductase] + O2 = 4alpha,5beta-5,20-epoxytax-11-ene-4,9-diol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 79167

phytol + hexadecanoyl-CoA = hexadecanoate phytyl ester + CoA

Direction not assertedBalancedRhea 79171

cyclohexane-1-carboxylate + succinyl-CoA = cyclohexane-1-carbonyl-CoA + succinate

Direction not assertedBalancedRhea 79175

cyclohexane-1-carboxylate + butanoyl-CoA = cyclohexane-1-carbonyl-CoA + butanoate

Direction not assertedBalancedRhea 79179

N-hydroxyputrescine + acetyl-CoA = N(1)-acetyl-N(1)-hydroxyputrescine + CoA

Direction not assertedBalancedRhea 79183

(2E,6Z,9Z,12Z,15Z,18Z,21Z)-tetracosaheptaenoyl-CoA + H2O = (3R)-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA

Left to rightBalancedRhea 79187

(3R)-hydroxy-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NAD(+) = 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + NADH + H(+)

Left to rightBalancedRhea 79191

a ganglioside GD1alpha + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1a alpha + CMP + H(+)

Direction not assertedBalance undeterminableRhea 79195

a ganglioside GA1 + 3'-phosphoadenylyl sulfate = a ganglioside SM1a + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalance undeterminableRhea 79199

a ganglioside GA1 + 3'-phosphoadenylyl sulfate = a ganglioside SM1b + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalance undeterminableRhea 79203

Page 334 of 372