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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Chemistry

Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

15,951–16,000 of 18,558 reactions from Rhea

pyridoxine(out) + n H(+)(out) = pyridoxine(in) + n H(+)(in)
Direction not assertedBalance undeterminableTransportRhea 76203
3',5'-cyclic GMP(in) = 3',5'-cyclic GMP(out)
Direction not assertedBalancedTransportRhea 76207
GMP(in) = GMP(out)
Direction not assertedBalancedTransportRhea 76211
2'-deoxyguanosine(in) = 2'-deoxyguanosine(out)
Direction not assertedBalancedTransportRhea 76215
GDP(in) = GDP(out)
Direction not assertedBalancedTransportRhea 76219
3',5'-cyclic AMP(in) = 3',5'-cyclic AMP(out)
Direction not assertedBalancedTransportRhea 76223
(Z)-(indol-3-yl)-N-(sulfonatooxy)methanimidothioate = (indol-3-yl)acetonitrile + sulfur + sulfate

Direction not assertedBalancedRhea 76227

2-oxoglutarate(in) = 2-oxoglutarate(out)

Direction not assertedBalancedTransportRhea 76231

a tRNA with a 3' CCA end + 2 CTP + ATP = a tRNA with a 3' CCACCA end + 3 diphosphate

Left to rightBalance undeterminableRhea 76235

L-tyrosyl-[protein] + L-ascorbate + L-lysyl-[protein] + 2 O2 = glycyl-[protein] + (S)-2-amino-6-oxohexanoyl-[protein] + 4-aminobenzoate + L-dehydroascorbate + 2 H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 76239

a glycyl-glycyl-[protein] + H2O = N-terminal glycyl-[protein] + [protein]-C-terminal glycine

Direction not assertedBalance undeterminableRhea 76243

ergothioneine(out) + ATP + H2O = ergothioneine(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 76247

glutarate(in) = glutarate(out)

Direction not assertedBalancedTransportRhea 76251

a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA = (2E,4S)-4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)

Left to rightBalance undeterminableRhea 76255

taurine(in) + H(+)(in) = taurine(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 76259

ergothioneine(in) = ergothioneine(out)

Right to leftBalancedTransportRhea 76263

carnosine(in) = carnosine(out)

Right to leftBalancedTransportRhea 76267

N,N-dimethylglycine(in) = N,N-dimethylglycine(out)

Right to leftBalancedTransportRhea 76271

uracil(out) + Na(+)(out) = uracil(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 76275

hypoxanthine(out) + Na(+)(out) = hypoxanthine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 76279

guanine(out) + Na(+)(out) = guanine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 76283

thymine(out) + Na(+)(out) = thymine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 76287

xanthine(out) + Na(+)(out) = xanthine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 76291

cob(I)alamin + S-adenosyl-L-methionine = methylcob(III)alamin + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 76295

L-cystine(out) + L-aspartate(in) = L-cystine(in) + L-aspartate(out)

Direction not assertedBalancedTransportRhea 76299

L-cystine(out) = L-cystine(in)

Direction not assertedBalancedTransportRhea 76303

L-aspartate(in) + L-glutamate(out) = L-aspartate(out) + L-glutamate(in)

Direction not assertedBalancedTransportRhea 76307

L-aspartate(in) + L-glutamine(out) = L-aspartate(out) + L-glutamine(in)

Direction not assertedBalancedTransportRhea 76311

L-aspartate(in) + L-methionine(out) = L-aspartate(out) + L-methionine(in)

Direction not assertedBalancedTransportRhea 76315

L-leucine(out) + L-aspartate(in) = L-leucine(in) + L-aspartate(out)

Direction not assertedBalancedTransportRhea 76319

L-valine(out) + L-aspartate(in) = L-valine(in) + L-aspartate(out)

Direction not assertedBalancedTransportRhea 76323

L-aspartate(in) + L-phenylalanine(out) = L-aspartate(out) + L-phenylalanine(in)

Direction not assertedBalancedTransportRhea 76327

L-tyrosine(out) + L-aspartate(in) = L-tyrosine(in) + L-aspartate(out)

Direction not assertedBalancedTransportRhea 76331

L-tryptophan(out) + L-aspartate(in) = L-tryptophan(in) + L-aspartate(out)

Direction not assertedBalancedTransportRhea 76335

urate(out) + 2 Na(+)(out) = urate(in) + 2 Na(+)(in)

Left to rightBalancedTransportRhea 76339

(2S)-2-isopropylmalate(in) + sulfate(out) = (2S)-2-isopropylmalate(out) + sulfate(in)

Direction not assertedBalancedTransportRhea 76343

(2R,3S)-3-isopropylmalate(in) + sulfate(out) = (2R,3S)-3-isopropylmalate(out) + sulfate(in)

Direction not assertedBalancedTransportRhea 76347

oxaloacetate(in) + sulfate(out) = oxaloacetate(out) + sulfate(in)

Direction not assertedBalancedTransportRhea 76351

N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine(out) + n H(+)(out) = N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanine(in) + n H(+)(in)

Left to rightBalance undeterminableTransportRhea 76355

N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate(out) + n H(+)(out) = N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate(in) + n H(+)(in)

Direction not assertedBalance undeterminableTransportRhea 76359

N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine(out) + n H(+)(out) = N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine(in) + n H(+)(in)

Direction not assertedBalance undeterminableTransportRhea 76363

N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramate(out) + n H(+)(out) = N-acetyl-beta-D-glucosaminyl-(1->4)-1,6-anhydro-N-acetyl-beta-D-muramate(in) + n H(+)(in)

Direction not assertedBalance undeterminableTransportRhea 76367

N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) + n H(+)(out) = N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in) + n H(+)(in)

Left to rightBalance undeterminableTransportRhea 76371

N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) + 3 H(+)(out) = N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in) + 3 H(+)(in)

Left to rightBalancedTransportRhea 76375

L-histidine(out) + n H(+)(out) = L-histidine(in) + n H(+)(in)

Left to rightBalance undeterminableTransportRhea 76379

carnosine(out) + n H(+)(out) = carnosine(in) + n H(+)(in)

Left to rightBalance undeterminableTransportRhea 76383

N(6)-hydroxy-L-lysine + L-glutamate + ATP = 1-L-glutamo-2-N(6-)L-lysinohydrazine + AMP + diphosphate + 2 H(+)

Direction not assertedBalancedRhea 76387

glycylglycylglycine(out) + n H(+)(out) = glycylglycylglycine(in) + n H(+)(in)

Left to rightBalance undeterminableTransportRhea 76391

N(6)-hydroxy-L-lysine + L-glutamate + ATP = O-glutamyl-N(6)-hydroxy-L-lysine + AMP + diphosphate

Direction not assertedBalancedRhea 76395

O-glutamyl-N(6)-hydroxy-L-lysine = 1-L-glutamo-2-N(6-)L-lysinohydrazine + 2 H(+)

Direction not assertedBalancedRhea 76399

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