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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
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PathwaysReactions grouped under one name
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
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Reference

Evidence

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Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

15,901–15,950 of 18,558 reactions from Rhea

kynurenate(out) + glutarate(in) = kynurenate(in) + glutarate(out)
Direction not assertedBalancedTransportRhea 75999
xanthurenate(out) + glutarate(in) = xanthurenate(in) + glutarate(out)
Direction not assertedBalancedTransportRhea 76003
(3R)-hydroxybutanoate pentamer + H2O = (3R)-hydroxybutanoate tetramer + (R)-3-hydroxybutanoate + H(+)
Direction not assertedBalancedRhea 76007
(3R)-hydroxybutanoate tetramer + H2O = (3R)-hydroxybutanoate trimer + (R)-3-hydroxybutanoate + H(+)
Direction not assertedBalancedRhea 76011
(3R)-hydroxybutanoate trimer + H2O = (3R)-hydroxybutanoate dimer + (R)-3-hydroxybutanoate + H(+)
Direction not assertedBalancedRhea 76015
cortisol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = 18-hydroxycortisol + 2 oxidized [adrenodoxin] + H2O
Left to rightBalance undeterminableRhea 76019

18-hydroxycortisol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = 18-oxocortisol + 2 oxidized [adrenodoxin] + 2 H2O

Left to rightBalance undeterminableRhea 76023

(S)-reticuline + 2-oxoglutarate + O2 = (S)-6-O-demethylreticuline + formaldehyde + succinate + CO2

Direction not assertedBalancedRhea 76027

(S)-cis-N-methylstylopine + reduced [NADPH--hemoprotein reductase] + O2 = protopine + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 76035

(S)-cis-N-methyltetrahydrothalifendine + reduced [NADPH--hemoprotein reductase] + O2 = 7-hydroxy-8-methoxy-11-methyl-17,19-dioxa-11-azatetracyclo[12.7.0.0(4,9).0(16,20)]henicosa-1(21),4(9),5,7,14,16(20)-hexaen-2-one + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 76039

(S)-cis-N-methyltetrahydropalmatine + reduced [NADPH--hemoprotein reductase] + O2 = muramine + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 76043

(S)-tetrahydropalmatine + S-adenosyl-L-methionine = (S)-cis-N-methyltetrahydropalmatine + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 76047

(S)-scoulerine + S-adenosyl-L-methionine = (S)-cis-N-methylscoulerine + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 76051

norreticuline + S-adenosyl-L-methionine = reticuline + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 76055

heliamine + S-adenosyl-L-methionine = N-methylheliamine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 76059

3'-phosphoadenylyl sulfate(in) + adenosine 3',5'-bisphosphate(out) = 3'-phosphoadenylyl sulfate(out) + adenosine 3',5'-bisphosphate(in)

Direction not assertedBalancedTransportRhea 76063

an (S)-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-methionine = an (S)-cis-N-methyl-7,8,13,14-tetrahydroprotoberberine + S-adenosyl-L-homocysteine

Direction not assertedBalance undeterminableRhea 76067

(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(out) + a dicarboxylate(in) = (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin(in) + a dicarboxylate(out)

Direction not assertedBalance undeterminableTransportRhea 76071

L-erythro-7,8-dihydrobiopterin(out) + a dicarboxylate(in) = L-erythro-7,8-dihydrobiopterin(in) + a dicarboxylate(out)

Direction not assertedBalance undeterminableTransportRhea 76075

L-sepiapterin(out) + a dicarboxylate(in) = L-sepiapterin(in) + a dicarboxylate(out)

Direction not assertedBalance undeterminableTransportRhea 76079

(11R)-carlactone + reduced [NADPH--hemoprotein reductase] + O2 = (11R)-19-hydroxycarlactone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 76083

kynurenate(out) + a dicarboxylate(in) = kynurenate(in) + a dicarboxylate(out)

Direction not assertedBalance undeterminableTransportRhea 76087

(11R)-19-hydroxycarlactone + reduced [NADPH--hemoprotein reductase] + O2 = (11R)-19-oxocarlactone + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 76091

(11R)-19-oxocarlactone + reduced [NADPH--hemoprotein reductase] + O2 = (11R)-carlactonoate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 76095

xanthurenate(out) + a dicarboxylate(in) = xanthurenate(in) + a dicarboxylate(out)

Direction not assertedBalance undeterminableTransportRhea 76099

(11R)-carlactonoate + S-adenosyl-L-methionine = (11R)-methyl carlactonoate + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 76103

(11R)-methyl carlactonoate + 2-oxoglutarate + O2 = (11R)-hydroxymethyl carlactonoate + succinate + CO2

Direction not assertedBalancedRhea 76107

4-methylumbelliferone beta-D-glucuronate + H2O = 4-methylumbelliferone + D-glucuronate

Direction not assertedBalancedRhea 76111

thebaine + 2-oxoglutarate + O2 = 6-O-demethylthebaine + formaldehyde + succinate + CO2 + H(+)

Direction not assertedBalancedRhea 76115

prostaglandin F2alpha(out) + a dicarboxylate(in) = prostaglandin F2alpha(in) + a dicarboxylate(out)

Direction not assertedBalance undeterminableTransportRhea 76119

prostaglandin E2(out) + a dicarboxylate(in) = prostaglandin E2(in) + a dicarboxylate(out)

Direction not assertedBalance undeterminableTransportRhea 76123

3',5'-cyclic AMP(out) + a dicarboxylate(in) = 3',5'-cyclic AMP(in) + a dicarboxylate(out)

Direction not assertedBalance undeterminableTransportRhea 76127

3',5'-cyclic GMP(out) + a dicarboxylate(in) = 3',5'-cyclic GMP(in) + a dicarboxylate(out)

Direction not assertedBalance undeterminableTransportRhea 76131

urate(out) + a dicarboxylate(in) = urate(in) + a dicarboxylate(out)

Direction not assertedBalance undeterminableTransportRhea 76135

D-gluconate(in) = D-gluconate(out)

Direction not assertedBalancedTransportRhea 76139

picrinine + S-adenosyl-L-methionine = ervincine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 76143

perivine + S-adenosyl-L-methionine = vobasine + S-adenosyl-L-homocysteine + 2 H(+)

Direction not assertedBalancedRhea 76147

21-hydroxyprogesterone + 2 reduced [adrenodoxin] + O2 + 2 H(+) = 18-hydroxy-11-deoxycorticosterone + 2 oxidized [adrenodoxin] + H2O

Left to rightBalance undeterminableRhea 76151

21-hydroxyprogesterone + 2 reduced [adrenodoxin] + O2 + 2 H(+) = 19-hydroxy-11-deoxycorticosterone + 2 oxidized [adrenodoxin] + H2O

Direction not assertedBalance undeterminableRhea 76155

fluoride(in) = fluoride(out)

Right to leftBalancedTransportRhea 76159

11-deoxycortisol + 2 reduced [adrenodoxin] + O2 + 2 H(+) = 18-hydroxy-11-deoxycortisol + 2 oxidized [adrenodoxin] + H2O

Direction not assertedBalance undeterminableRhea 76163

glycyl-L-leucine(out) + 2 H(+)(out) = glycyl-L-leucine(in) + 2 H(+)(in)

Left to rightBalancedTransportRhea 76167

glycyl-L-lysine(out) + 2 H(+)(out) = glycyl-L-lysine(in) + 2 H(+)(in)

Left to rightBalancedTransportRhea 76171

glycyl-L-glutamate(out) + 3 H(+)(out) = glycyl-L-glutamate(in) + 3 H(+)(in)

Left to rightBalancedTransportRhea 76175

a dipeptide(out) + 2 H(+)(out) = a dipeptide(in) + 2 H(+)(in)

Left to rightBalance undeterminableTransportRhea 76179

L-alanyl-L-alanine(out) + 2 H(+)(out) = L-alanyl-L-alanine(in) + 2 H(+)(in)

Left to rightBalancedTransportRhea 76183

an L-amino acid tripeptide(out) + 2 H(+)(out) = an L-amino acid tripeptide(in) + 2 H(+)(in)

Left to rightBalance undeterminableTransportRhea 76187

carnosine(out) + 2 H(+)(out) = carnosine(in) + 2 H(+)(in)

Left to rightBalancedTransportRhea 76191

UDP-alpha-D-glucose(in) = UDP-alpha-D-glucose(out)

Direction not assertedBalancedTransportRhea 76195

oxalate(in) = oxalate(out)

Direction not assertedBalancedTransportRhea 76199

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