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CompoundsSubstances with curated findings
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ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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Reference

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

15,551–15,600 of 18,558 reactions from Rhea

(2E,6E)-farnesyl diphosphate = (+)-exo-beta-bergamotene + diphosphate
Direction not assertedBalancedRhea 74587
(+)-exo-beta-bergamotene + 2 reduced [NADPH--hemoprotein reductase] + 3 O2 = 5-dehydro-6-demethoxyfumagillol + 2 oxidized [NADPH--hemoprotein reductase] + 3 H2O + 2 H(+)
Direction not assertedBalance undeterminableRhea 74591
(2S,3R)-3-methyl-L-aspartate = mesaconate + NH4(+)
Direction not assertedBalancedRhea 74595
UDP-alpha-D-galactose(in) + AMP(out) = UDP-alpha-D-galactose(out) + AMP(in)
Direction not assertedBalancedTransportRhea 74599
UDP-alpha-D-galactose(in) + CMP(out) = UDP-alpha-D-galactose(out) + CMP(in)
Direction not assertedBalancedTransportRhea 74603
UDP-N-acetyl-alpha-D-galactosamine(out) + UDP-alpha-D-galactose(in) = UDP-N-acetyl-alpha-D-galactosamine(in) + UDP-alpha-D-galactose(out)
Direction not assertedBalanced

Transport

Rhea 74607

UDP-N-acetyl-alpha-D-glucosamine(out) + UDP-alpha-D-galactose(in) = UDP-N-acetyl-alpha-D-glucosamine(in) + UDP-alpha-D-galactose(out)

Direction not assertedBalancedTransportRhea 74611

UDP-alpha-D-galactose(in) + UDP-alpha-D-glucose(out) = UDP-alpha-D-galactose(out) + UDP-alpha-D-glucose(in)

Direction not assertedBalancedTransportRhea 74615

UMP(out) + CMP(in) = UMP(in) + CMP(out)

Direction not assertedBalancedTransportRhea 74619

UMP(out) + AMP(in) = UMP(in) + AMP(out)

Direction not assertedBalancedTransportRhea 74623

prefumagillin + NADPH + 2 O2 = fumagillin + acetaldehyde + NADP(+) + H2O

Direction not assertedBalancedRhea 74627

O-acetyl-L-homoserine + 3-methyl-2-oxobutanoate = (6S)-6-amino-3,3-dimethyl-2-oxoheptanedioate + acetate + H(+)

Direction not assertedBalancedRhea 74631

5-dehydro-6-demethoxyfumagillol + 2-oxoglutarate + O2 = 5-dehydro-6-demethoxy-6-hydroxyfumagillol + succinate + CO2

Direction not assertedBalancedRhea 74635

CMP-N-acetyl-beta-neuraminate(in) + AMP(out) = CMP-N-acetyl-beta-neuraminate(out) + AMP(in)

Direction not assertedBalancedTransportRhea 74639

UMP(out) + CMP-N-acetyl-beta-neuraminate(in) = UMP(in) + CMP-N-acetyl-beta-neuraminate(out)

Direction not assertedBalancedTransportRhea 74643

N-acetyl-D-glucosamine + GTP = N-acetyl-D-glucosamine 6-phosphate + GDP + H(+)

Direction not assertedBalancedRhea 74647

N-acetyl-D-glucosamine + CTP = N-acetyl-D-glucosamine 6-phosphate + CDP + H(+)

Direction not assertedBalancedRhea 74651

ITP + N-acetyl-D-glucosamine = IDP + N-acetyl-D-glucosamine 6-phosphate + H(+)

Direction not assertedBalancedRhea 74655

N-acetyl-D-glucosamine + UTP = N-acetyl-D-glucosamine 6-phosphate + UDP + H(+)

Direction not assertedBalancedRhea 74659

acetylcholine(in) = acetylcholine(out)

ReversibleBalancedTransportRhea 74663

(6S)-6-amino-3,3-dimethyl-2-oxoheptanedioate = (2S)-5,5-dimethyl-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O + H(+)

Direction not assertedBalancedRhea 74667

UDP-beta-L-arabinopyranose(in) + UMP(out) = UDP-beta-L-arabinopyranose(out) + UMP(in)

Direction not assertedBalancedTransportRhea 74671

archaeol + AH2 + 2 S-adenosyl-L-methionine = macrocyclic archaeol + 2 5'-deoxyadenosine + 2 L-methionine + A + 2 H(+)

Direction not assertedBalancedRhea 74675

UDP-beta-L-arabinofuranose(in) + UMP(out) = UDP-beta-L-arabinofuranose(out) + UMP(in)

Direction not assertedBalancedTransportRhea 74679

2 archaeol + 2 AH2 + 4 S-adenosyl-L-methionine = glycerol dibiphytanyl glycerol tetraether + 4 5'-deoxyadenosine + 4 L-methionine + 2 A + 4 H(+)

Direction not assertedBalancedRhea 74683

a 2,3-di-O-phytanyl-sn-glycerophospholipid + AH2 + 2 S-adenosyl-L-methionine = a macrocyclic archaeaol phospholipid + 2 5'-deoxyadenosine + 2 L-methionine + A + 2 H(+)

Direction not assertedBalance undeterminableRhea 74687

2 a 2,3-di-O-phytanyl-sn-glycerophospholipid + 2 AH2 + 4 S-adenosyl-L-methionine = a glycerol dibiphytanyl glycerol tetraether phospholipid + 4 5'-deoxyadenosine + 4 L-methionine + 2 A + 4 H(+)

Direction not assertedBalance undeterminableRhea 74691

(+)-exo-beta-bergamotene + reduced [NADPH--hemoprotein reductase] + O2 = (5R)-hydroxy-beta-trans-bergamotene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 74695

(5R)-hydroxy-beta-trans-bergamotene + O2 = (3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + H2O

Direction not assertedBalancedRhea 74699

(3S)-3-[2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]-4-methylidenecyclohexan-1-one + reduced [NADPH--hemoprotein reductase] + O2 = 5-dehydro-6-demethoxyfumagillol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 74703

fumagillol + NADP(+) = 5-dehydrofumagillol + NADPH + H(+)

Direction not assertedBalancedRhea 74707

5-dehydro-6-demethoxy-6-hydroxyfumagillol + S-adenosyl-L-methionine = 5-dehydrofumagillol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 74711

3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine = 3,3'-O-dimethylquercetin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 74715

myricetin + S-adenosyl-L-methionine = 7-O-methylmyricetin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 74719

isorhamnetin + S-adenosyl-L-methionine = 3',4'-O-dimethylquercetin + S-adenosyl-L-homocysteine + 2 H(+)

Direction not assertedBalancedRhea 74723

holo-[polyketide synthase] + 5 malonyl-CoA + acetyl-CoA + 5 NADPH + 10 H(+) = dodecapentaneoyl-[polyketide synthase] + 5 CO2 + 5 NADP(+) + 6 CoA + 5 H2O

Direction not assertedBalance undeterminableRhea 74727

rhamnetin + S-adenosyl-L-methionine = 7,4'-O-dimethylquercetin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 74731

syringetin + S-adenosyl-L-methionine = 7,3',5'-O-trimethylmyricetin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 74735

3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine = 7,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 74739

kaempferol + S-adenosyl-L-methionine = 3-O-methylkaempferol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 74743

myricetin + S-adenosyl-L-methionine = 3-O-methylmyricetin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 74747

fumagillol + dodecapentaneoyl-[polyketide synthase] = prefumagillin + holo-[polyketide synthase]

Direction not assertedBalance undeterminableRhea 74751

kaempferide + S-adenosyl-L-methionine = 3,4'-O-dimethylkaempferol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 74755

isorhamnetin + S-adenosyl-L-methionine = 3,3'-O-dimethylquercetin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 74759

rhamnetin + S-adenosyl-L-methionine = 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 74763

syringetin + S-adenosyl-L-methionine = 3,3',5'-O-trimethylmyricetin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 74767

3',4',5'-O-trimethylmyricetin + S-adenosyl-L-methionine = 3,3',4',5'-O-tetramethylmyricetin + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 74771

kaempferide + S-adenosyl-L-methionine = 7,4'-O-dimethylkaempferol + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 74775

laricitrin + S-adenosyl-L-methionine = 3,3'-O-dimethylmyricetin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 74779

tyramine(in) = tyramine(out)

Direction not assertedBalancedTransportRhea 74783

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