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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Chemistry

Reactions
Reach

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Processes
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Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

15,451–15,500 of 18,558 reactions from Rhea

taxifolin + S-adenosyl-L-methionine = taxifolin 3'-methyl ether + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalancedRhea 74187
carbofuran + H2O + H(+) = 2,2-dimethyl-2,3-dihydro-1-benzofuran-7-ol + methylamine + CO2
Direction not assertedBalancedRhea 74191
aspulvinone E + O2 = (5Z)-3-(3,4-dihydroxyphenyl)-5-[(3,4-dihydroxyphenyl)methylidene]-5-oxo-2,5-dihydrofuran-3-olate
Direction not assertedBalancedRhea 74195
aspulvinone E + O2 = (2Z)-2-[(3,4-dioxocyclohexa-1,5-dien-1-yl)methylidene]-4-(4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-3-olate + H2O
Direction not assertedBalancedRhea 74199
tryptamine + S-adenosyl-L-methionine = N-methyltryptamine + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalancedRhea 74203
N-methyltryptamine + S-adenosyl-L-methionine = N,N-dimethyltryptamine + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalanced

Rhea 74207

L-threonyl-tRNA(Lys) + H2O = tRNA(Lys) + L-threonine

Direction not assertedBalancedRhea 74211

L-seryl-tRNA(Lys) + H2O = tRNA(Lys) + L-serine

Direction not assertedBalancedRhea 74215

L-seryl-tRNA(Thr) + H2O = tRNA(Thr) + L-serine

Direction not assertedBalancedRhea 74219

L-seryl-tRNA(Ala) + H2O = tRNA(Ala) + L-serine

Direction not assertedBalancedRhea 74223

L-threonyl-tRNA(Ile) + H2O = tRNA(Ile) + L-threonine

Direction not assertedBalancedRhea 74227

L-threonyl-tRNA(Val) + H2O = tRNA(Val) + L-threonine

Direction not assertedBalancedRhea 74231

L-threonyl-tRNA(Ser) + H2O = tRNA(Ser) + L-threonine

Direction not assertedBalancedRhea 74235

solabiose + phosphate = D-galactose + alpha-D-glucose 1-phosphate

Direction not assertedBalancedRhea 74239

L-alanyl-tRNA(Pro) + H2O = tRNA(Pro) + L-alanine + H(+)

Direction not assertedBalancedRhea 74243

1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)

Left to rightBalance undeterminableRhea 74247

1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + H2O = 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + a fatty acid + H(+)

Left to rightBalance undeterminableRhea 74251

L-homoseryl-tRNA(Ser) + H2O = tRNA(Ser) + L-homoserine + H(+)

Direction not assertedBalancedRhea 74255

L-homoseryl-tRNA(Lys) + H2O = tRNA(Lys) + L-homoserine + H(+)

Direction not assertedBalancedRhea 74259

spermine(in) + n H(+)(out) = spermine(out) + n H(+)(in)

Left to rightBalance undeterminableTransportRhea 74263

spermidine(in) + n H(+)(out) = spermidine(out) + n H(+)(in)

Left to rightBalance undeterminableTransportRhea 74267

an alpha-Kdo-(2->6)-lipid IVA + ATP = a 4-O-phospho-alpha-Kdo-(2->6)-lipid IVA + ADP + H(+)

Direction not assertedBalance undeterminableRhea 74271

a lipid A + a 1,2-diacyl-sn-glycero-3-phosphocholine = a hepta-acyl lipid A + a 2-acyl-sn-glycero-3-phosphocholine

Direction not assertedBalance undeterminableRhea 74275

a lipid IVA + a 1,2-diacyl-sn-glycero-3-phosphocholine = a lipid IVB + a 2-acyl-sn-glycero-3-phosphocholine

Direction not assertedBalance undeterminableRhea 74279

a lipid IIA + a 1,2-diacyl-sn-glycero-3-phosphocholine = a lipid IIB + a 2-acyl-sn-glycero-3-phosphocholine

Direction not assertedBalance undeterminableRhea 74283

an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + a fatty acyl-[ACP] = an acyl-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + holo-[ACP]

Direction not assertedBalance undeterminableRhea 74287

an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + di-trans,octa-cis-undecaprenyl diphosphate = an alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A 1-diphosphate + di-trans,octa-cis-undecaprenyl phosphate

Direction not assertedBalance undeterminableRhea 74291

serotonin(in) + n H(+)(out) = serotonin(out) + n H(+)(in)

Left to rightBalance undeterminableTransportRhea 74295

D-isoleucine(out) + D-serine(in) = D-isoleucine(in) + D-serine(out)

Left to rightBalancedTransportRhea 74299

12alpha-hydroxy-3-oxochola-4-en-24-oate + NAD(+) = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + NADH + H(+)

Direction not assertedBalancedRhea 74303

12alpha-hydroxy-3-oxo-5beta-cholan-24-oate + NAD(+) = 12alpha-hydroxy-3-oxochola-4-en-24-oate + NADH + H(+)

Direction not assertedBalancedRhea 74307

12alpha-hydroxy-3-oxochola-4,6-dien-24-oyl-CoA + H2O = 12alpha-hydroxy-3-oxochola-4,6-dien-24-oate + CoA + H(+)

Direction not assertedBalancedRhea 74311

O-isobutanoyl-(R)-carnitine(in) = O-isobutanoyl-(R)-carnitine(out)

Direction not assertedBalancedTransportRhea 74315

O-acetyl-(R)-carnitine(in) = O-acetyl-(R)-carnitine(out)

ReversibleBalancedTransportRhea 74319

O-3-hydroxybutanoyl-(R)-carnitine(in) = O-3-hydroxybutanoyl-(R)-carnitine(out)

Direction not assertedBalancedTransportRhea 74323

O-propanoyl-(R)-carnitine(in) = O-propanoyl-(R)-carnitine(out)

Direction not assertedBalancedTransportRhea 74327

O-butanoyl-(R)-carnitine(in) = O-butanoyl-(R)-carnitine(out)

Direction not assertedBalancedTransportRhea 74331

O-2-methylbutanoyl-(R)-carnitine(in) = O-2-methylbutanoyl-(R)-carnitine(out)

Direction not assertedBalancedTransportRhea 74335

O-3-methylbutanoyl-(R)-carnitine(in) = O-3-methylbutanoyl-(R)-carnitine(out)

Direction not assertedBalancedTransportRhea 74339

O-hexanoyl-(R)-carnitine(in) = O-hexanoyl-(R)-carnitine(out)

Direction not assertedBalancedTransportRhea 74343

an O-acyl-(R)-carnitine(in) = an O-acyl-(R)-carnitine(out)

Direction not assertedBalance undeterminableTransportRhea 74347

prostaglandin E3(out) + 2 (S)-lactate(in) = prostaglandin E3(in) + 2 (S)-lactate(out)

Direction not assertedBalancedTransportRhea 74351

a cytidine in mRNA + H2O + H(+) = a uridine in mRNA + NH4(+)

Left to rightBalance undeterminableRhea 74355

coproporphyrin I(out) = coproporphyrin I(in)

Direction not assertedBalancedTransportRhea 74359

coproporphyrin III(out) = coproporphyrin III(in)

Direction not assertedBalancedTransportRhea 74363

substance P(out) = substance P(in)

Direction not assertedBalancedTransportRhea 74367

nicotinate(in) + a carboxylate(out) = nicotinate(out) + a carboxylate(in)

Direction not assertedBalance undeterminableTransportRhea 74371

H2O2(out) = H2O2(in)

Direction not assertedBalancedTransportRhea 74375

prostaglandin H2(out) + 2 (S)-lactate(in) = prostaglandin H2(in) + 2 (S)-lactate(out)

Direction not assertedBalancedTransportRhea 74379

prostaglandin E2(out) + 2 (S)-lactate(in) = prostaglandin E2(in) + 2 (S)-lactate(out)

Direction not assertedBalancedTransportRhea 74383

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