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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Proteins
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Reactions
Reach

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Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

1,501–1,550 of 18,558 reactions from Rhea

NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)
Left to rightBalancedRhea 16301
(3S)-3-hydroxy-3-methylglutaryl-CoA + H2O = 3-hydroxy-3-methylglutarate + CoA + H(+)
Left to rightBalancedRhea 16305
taurochenodeoxycholate + H2O = chenodeoxycholate + taurine
Direction not assertedBalancedRhea 16309
5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene + H2O = 5-(3-hydroxy-4-acetoxybut-1-ynyl)-2,2'-bithiophene + acetate + H(+)
Direction not assertedBalancedRhea 16313
(S)-indan-1-ol + NAD(+) = indan-1-one + NADH + H(+)
Direction not assertedBalancedRhea 16317
(S)-indan-1-ol + NADP(+) = indan-1-one + NADPH + H(+)
Direction not assertedBalancedRhea 16321
1-phospho-alpha-D-glucuronate + UTP + H(+) = UDP-alpha-D-glucuronate + diphosphate

Direction not assertedBalancedRhea 16325

(9Z,12Z,15Z)-octadecatrienoate + O2 = (R)-2-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate

Direction not assertedBalancedRhea 16329

apo-[citrate lyase ACP] + 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA = holo-[citrate lyase ACP] + diphosphate

Direction not assertedBalance undeterminableRhea 16333

a 3'-unsubstituted flavone + reduced [NADPH--hemoprotein reductase] + O2 = a 3'-hydroxyflavone + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 16337

(R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP

ReversibleBalancedRhea 16341

(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (3E,7E)-dolabella-3,7-dien-18-ol + diphosphate

Direction not assertedBalancedRhea 16345

chlorate + AH2 = chlorite + A + H2O

Direction not assertedBalancedRhea 16349

taurine + 2-oxoglutarate = sulfoacetaldehyde + L-glutamate

Direction not assertedBalancedRhea 16353

succinate + A = fumarate + AH2

Direction not assertedBalancedRhea 16357

2-acetolactate = 3-hydroxy-3-methyl-2-oxobutanoate

Direction not assertedBalancedRhea 16361

digallate + H2O = 2 3,4,5-trihydroxybenzoate + H(+)

Direction not assertedBalancedRhea 16365

(R)-lactate + NAD(+) = pyruvate + NADH + H(+)

Direction not assertedBalancedRhea 16369

(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)

Direction not assertedBalancedRhea 16373

(3Z)-phytochromobilin + 2 oxidized [2Fe-2S]-[ferredoxin] = biliverdin IXalpha + 2 reduced [2Fe-2S]-[ferredoxin] + 2 H(+)

Direction not assertedBalance undeterminableRhea 16377

L-arabinitol + NAD(+) = L-xylulose + NADH + H(+)

Direction not assertedBalancedRhea 16381

4-hydroxybenzoate + NADPH + O2 + 2 H(+) = hydroquinone + CO2 + NADP(+) + H2O

Direction not assertedBalancedRhea 16385

4-hydroxybenzoate + NADH + O2 + 2 H(+) = hydroquinone + CO2 + NAD(+) + H2O

Direction not assertedBalancedRhea 16389

juvenile hormone II + H2O = juvenile hormone II carboxylate + methanol + H(+)

Direction not assertedBalancedRhea 16393

2 D-glucopyranose 1-phosphate = D-glucose 1,6-bisphosphate + D-glucose

Direction not assertedBalancedRhea 16397

benzyl (2R,3S)-2-methyl-3-hydroxybutanoate + NADP(+) = benzyl 2-methyl-3-oxobutanoate + NADPH + H(+)

Direction not assertedBalancedRhea 16405

(2R)-1,2-dihydrovomilenine + NADP(+) = vomilenine + NADPH + H(+)

Direction not assertedBalancedRhea 16409

N(6)-[(R)-lipoyl]-L-lysyl-[glycine-cleavage complex H protein] + L-lysyl-[lipoyl-carrier protein] = L-lysyl-[glycine-cleavage complex H protein] + N(6)-[(R)-lipoyl]-L-lysyl-[lipoyl-carrier protein]

Left to rightBalance undeterminableRhea 16413

(S)-1-pyrroline-5-carboxylate + NAD(+) + 2 H2O = L-glutamate + NADH + H(+)

Direction not assertedBalancedRhea 16417

an aldehyde + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O = a carboxylate + 2 reduced [2Fe-2S]-[ferredoxin] + 3 H(+)

Direction not assertedBalance undeterminableRhea 16421

formaldehyde + NAD(+) + H2O = formate + NADH + 2 H(+)

Direction not assertedBalancedRhea 16425

UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate + ATP = UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 16429

RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

Left to rightBalance undeterminableRhea 16437

L-glutaminyl-[protein] + H2O = L-glutamyl-[protein] + NH4(+)

Left to rightBalance undeterminableRhea 16441

(2R,3S)-2,4',7-trihydroxyisoflavanone = daidzein + H2O + H(+)

Direction not assertedBalancedRhea 16445

kanamycin B + acetyl-CoA = N(6')-acetylkanamycin B + CoA + H(+)

Direction not assertedBalancedRhea 16449

(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate + H2O = 2-formylbenzoate + pyruvate

Direction not assertedBalancedRhea 16453

(2R,3S)-tartrate + NAD(+) = 2-hydroxy-3-oxosuccinate + NADH + H(+)

Direction not assertedBalancedRhea 16457

urate(in) + ATP + H2O = urate(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 16461

2 Fe(III)-[cytochrome c553] + (R)-lactate = 2 Fe(II)-[cytochrome c553] + pyruvate + 2 H(+)

Direction not assertedBalance undeterminableRhea 16465

(R)-2-benzylsuccinate + succinyl-CoA = (R)-2-benzylsuccinyl-CoA + succinate

Direction not assertedBalancedRhea 16469

cyclohexane-1,3-dione + H2O = 5-oxohexanoate + H(+)

Direction not assertedBalancedRhea 16473

prostaglandin E1 + NAD(+) = 15-oxoprostaglandin E1 + NADH + H(+)

Left to rightBalancedRhea 16477

3 S-adenosyl-L-methionine = nicotianamine + 3 S-methyl-5'-thioadenosine + 3 H(+)

Direction not assertedBalancedRhea 16481

imidazole-4-acetate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = 1-(5-phosphoribosyl)imidazole-4-acetate + ADP + phosphate + diphosphate + H(+)

Direction not assertedBalancedRhea 16485

(R)-prunasin + H2O = mandelonitrile + D-glucose

Direction not assertedBalancedRhea 16489

glycerol 1,2-cyclic phosphate + H2O = glycerol 1-phosphate + H(+)

Direction not assertedBalancedRhea 16493

adenosine(1618) in 23S rRNA + S-adenosyl-L-methionine = N(6)-methyladenosine(1618) in 23S rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 16497

sn-glycero-3-phospho-1D-myo-inositol + H2O = myo-inositol + sn-glycerol 3-phosphate + H(+)

Left to rightBalancedRhea 16501

chorismate = 4-hydroxybenzoate + pyruvate

Direction not assertedBalancedRhea 16505

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