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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

15,351–15,400 of 18,558 reactions from Rhea

tardioxopiperazine A + dimethylallyl diphosphate = variecolorin L + diphosphate
Direction not assertedBalancedRhea 73787
neoechinulin A + dimethylallyl diphosphate = variecolorin G + diphosphate
Direction not assertedBalancedRhea 73791
neoechinulin A + dimethylallyl diphosphate = isoechinulin A + diphosphate
Direction not assertedBalancedRhea 73795
isoechinulin A + dimethylallyl diphosphate = dehydroechinulin + diphosphate
Direction not assertedBalancedRhea 73799
neoechinulin B + dimethylallyl diphosphate = isoechinulin B + diphosphate
Direction not assertedBalancedRhea 73803
GDP + S-adenosyl-L-methionine = N(7)-methyl-GDP + S-adenosyl-L-homocysteine
Direction not assertedBalancedRhea 73807
L-proline(in) = L-proline(out)

Direction not assertedBalancedTransportRhea 73811

piceatannol + O2 = 3,5-dihydroxybenzaldehyde + 3,4-dihydroxybenzaldehyde

Direction not assertedBalancedRhea 73815

choline(in) + 2 H(+)(out) = choline(out) + 2 H(+)(in)

Left to rightBalancedTransportRhea 73819

an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)

Direction not assertedBalance undeterminableRhea 73823

an alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = an alpha-Kdo-(2->8)-[alpha-Kdo-(2->4)]-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)

Direction not assertedBalance undeterminableRhea 73827

an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = an alpha-Kdo-(2->4)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)

Direction not assertedBalance undeterminableRhea 73831

sn-3-(O-farnesylgeranyl)glycerol 1-phosphate + (2E,6E,10E,14E)-geranylfarnesyl diphosphate = 2,3-bis-O-(geranylfarnesyl)-sn-glycerol 1-phosphate + diphosphate

Direction not assertedBalancedRhea 73835

phenol + ATP + H2O = phenyl phosphate + AMP + phosphate + 2 H(+)

Direction not assertedBalancedRhea 73839

a 27-hydroxysterol + UDP-alpha-D-glucose = a sterol 27-beta-D-glucoside + UDP + H(+)

Direction not assertedBalancedRhea 73843

17alpha-hydroxywithaferin A + UDP-alpha-D-glucose = 17alpha-sitoindoside IX + UDP + H(+)

Direction not assertedBalancedRhea 73847

27-hydroxywithanone + UDP-alpha-D-glucose = withanone 27-O-beta-D-glucoside + UDP + H(+)

Direction not assertedBalancedRhea 73851

5alpha,6beta,17alpha,27-tetrahydroxywithanolide + UDP-alpha-D-glucose = 5alpha,6beta,17alpha-trihydroxywithanolide 27-O-beta-D-glucoside + UDP + H(+)

Direction not assertedBalancedRhea 73855

1-methylnicotinamide(out) = 1-methylnicotinamide(in)

Direction not assertedBalancedTransportRhea 73859

dopamine(out) = dopamine(in)

Direction not assertedBalancedTransportRhea 73863

serotonin(out) = serotonin(in)

Direction not assertedBalancedTransportRhea 73867

(R)-noradrenaline(out) = (R)-noradrenaline(in)

Direction not assertedBalancedTransportRhea 73871

(R)-adrenaline(out) = (R)-adrenaline(in)

Direction not assertedBalancedTransportRhea 73875

histamine(out) = histamine(in)

Direction not assertedBalancedTransportRhea 73879

guanidine(out) = guanidine(in)

Direction not assertedBalancedTransportRhea 73883

chloride(out) + Na(+)(out) = chloride(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 73887

spermidine + L-glutamate + ATP = gamma-L-glutamylspermidine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 73891

spermine + L-glutamate + ATP = gamma-L-glutamylspermine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 73895

cadaverine + L-glutamate + ATP = gamma-L-glutamylcadaverine + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 73899

ethanolamine + L-glutamate + ATP = gamma-L-glutamylethanolamide + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 73903

4-hydroxy-N,N,N-trimethyltryptamine + ATP = aeruginascin + ADP + H(+)

Direction not assertedBalancedRhea 73907

psilocin + ATP = psilocybin + ADP + H(+)

Direction not assertedBalancedRhea 73911

6 malonyl-CoA + acetyl-CoA + 4 H(+) = 2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + 6 CO2 + 7 CoA + H2O

Direction not assertedBalancedRhea 73915

2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + H(+) = norlichexanthone + H2O

Direction not assertedBalancedRhea 73919

2-(2,4-dihydroxy-6-oxidobenzoyl)-5-hydroxy-3-methylbenzenolate + S-adenosyl-L-methionine = griseophenone D + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 73923

griseophenone D + S-adenosyl-L-methionine = griseophenone C + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 73927

griseophenone C + FADH2 + chloride + O2 = griseophenone B + FAD + 2 H2O + H(+)

Direction not assertedBalancedRhea 73931

griseophenone B + reduced [NADPH--hemoprotein reductase] + O2 + H(+) = desmethyl-dehydrogriseofulvin + oxidized [NADPH--hemoprotein reductase] + 2 H2O

Direction not assertedBalance undeterminableRhea 73935

desmethyl-dehydrogriseofulvin + S-adenosyl-L-methionine = dehydrogriseofulvin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 73939

dehydrogriseofulvin + NADPH + H(+) = griseofulvin + NADP(+)

Direction not assertedBalancedRhea 73943

(2E)-geranyl diphosphate = (4E,6E)-allo-ocimene + diphosphate

Direction not assertedBalancedRhea 73947

(2E,6E)-farnesyl diphosphate = beta-maaliene + diphosphate

Direction not assertedBalancedRhea 73951

3,4-dihydroxystyrene + NADH + H(+) = 4-ethylcatechol + NAD(+)

Direction not assertedBalancedRhea 73955

2-methoxy-4-vinylphenol + NADH + H(+) = 4-ethyl-2-methoxyphenol + NAD(+)

Direction not assertedBalancedRhea 73959

(2E,6E)-farnesyl diphosphate = aristolene + diphosphate

Direction not assertedBalancedRhea 73963

1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoate + H(+)

Left to rightBalancedRhea 73967

a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + a fatty acid + H(+)

Left to rightBalance undeterminableRhea 73971

a 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphate + H2O = 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + a fatty acid + H(+)

Left to rightBalance undeterminableRhea 73975

(2E,6E)-farnesyl diphosphate = calarene + diphosphate

Direction not assertedBalancedRhea 73979

(2E,6E)-farnesyl diphosphate = (-)-beta-barbatene + diphosphate

Direction not assertedBalancedRhea 73983

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