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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

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Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

15,201–15,250 of 18,558 reactions from Rhea

FAD(out) + ADP(in) = FAD(in) + ADP(out)
Direction not assertedBalancedTransportRhea 73183
(R)-benzodiazepinedione + dimethylallyl diphosphate = (2R,3S,11R)-aszonalenin + diphosphate
Direction not assertedBalancedRhea 73187
(2R,3S,11R)-aszonalenin + acetyl-CoA = (2R,3S,11R)-acetylaszonalenin + CoA
Direction not assertedBalancedRhea 73191
malonate(in) + sulfate(out) = malonate(out) + sulfate(in)
Direction not assertedBalancedTransportRhea 73195
maleate(in) + sulfate(out) = maleate(out) + sulfate(in)
Direction not assertedBalancedTransportRhea 73199
D-glucose(out) + H(+)(in) = D-glucose(in) + H(+)(out)
Direction not assertedBalancedTransportRhea 73203
sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)

Direction not assertedBalancedTransportRhea 73207

sucrose(out) + H(+)(in) = sucrose(in) + H(+)(out)

Direction not assertedBalancedTransportRhea 73211

thiosulfate(in) + sulfate(out) = thiosulfate(out) + sulfate(in)

Direction not assertedBalancedTransportRhea 73215

L-xylopyranose(out) + 2 Na(+)(out) = L-xylopyranose(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 73219

(3S)-citramalate(in) + sulfate(out) = (3S)-citramalate(out) + sulfate(in)

Direction not assertedBalancedTransportRhea 73223

(3R)-citramalate(in) + sulfate(out) = (3R)-citramalate(out) + sulfate(in)

Direction not assertedBalancedTransportRhea 73227

2,4,6-trichlorophenol + FADH2 + O2 = 2-chloro-6-hydroxy-1,4-benzoquinone + FAD + 2 chloride + 3 H(+)

Direction not assertedBalancedRhea 73231

2,6-dichlorobenzoquinone + H2O = 2-chloro-6-hydroxy-1,4-benzoquinone + chloride + 2 H(+)

Direction not assertedBalancedRhea 73235

scutellarein 7-methyl ether + S-adenosyl-L-methionine = ladanein + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 73239

scutellarein 7-methyl ether + S-adenosyl-L-methionine = cirsimaritin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 73243

ladanein + S-adenosyl-L-methionine = salvigenin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 73247

cirsimaritin + S-adenosyl-L-methionine = salvigenin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 73251

(2S)-sakuranetin + S-adenosyl-L-methionine = (2S)-naringenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 73255

cirsiliol + S-adenosyl-L-methionine = eupatorin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 73259

genkwanin + S-adenosyl-L-methionine = apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 73263

L-methionine(in) + H(+)(out) = L-methionine(out) + H(+)(in)

Direction not assertedBalancedTransportRhea 73267

rhamnetin + S-adenosyl-L-methionine = rhamnacene + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 73271

3',4',7,8-tetrahydroxyflavone + S-adenosyl-L-methionine = 4',7,8-trihydroxy-3'-methoxyflavone-7-olate + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 73275

L-isoleucine(in) + H(+)(out) = L-isoleucine(out) + H(+)(in)

Direction not assertedBalancedTransportRhea 73283

(2S)-naringenin + S-adenosyl-L-methionine = (2S)-naringenin 4'-methyl ether + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 73287

L-valine(in) + H(+)(out) = L-valine(out) + H(+)(in)

Direction not assertedBalancedTransportRhea 73291

4',7,8-trihydroxyflavone + S-adenosyl-L-methionine = 7,8-dihydroxy-4'-methoxyflavone + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 73295

(S)-malate(out) + phosphate(in) + H(+)(in) = (S)-malate(in) + phosphate(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 73299

oxaloacetate(out) + phosphate(in) + H(+)(in) = oxaloacetate(in) + phosphate(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 73303

L-aspartate(out) + phosphate(in) + H(+)(in) = L-aspartate(in) + phosphate(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 73307

L-thyroxine sulfate(out) = L-thyroxine sulfate(in)

Direction not assertedBalancedTransportRhea 73311

1D-chiro-inositol(out) + 2 Na(+)(out) = 1D-chiro-inositol(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 73315

(2R,3S)-piscidate + (E)-4-coumaroyl-CoA = cimicifugate K + CoA

Direction not assertedBalancedRhea 73319

(2R,3S)-piscidate + (E)-caffeoyl-CoA = cimicifugate D + CoA

Direction not assertedBalancedRhea 73323

(2R,3S)-piscidate + (E)-sinapoyl-CoA = cimicifugate J + CoA

Direction not assertedBalancedRhea 73327

(2R,3S)-piscidate + (E)-feruloyl-CoA = cimicifugate E + CoA

Direction not assertedBalancedRhea 73331

tryptamine + beta-alanine + ATP = beta-alanyl-tryptamine + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 73335

beta-alanine + ATP + H(+) = beta-alanyl-5'-AMP + diphosphate

Direction not assertedBalancedRhea 73339

beta-alanyl-5'-AMP + holo-[peptidyl-carrier protein] = beta-alanyl-[peptidyl-carrier protein] + AMP + H(+)

Direction not assertedBalance undeterminableRhea 73343

beta-alanyl-[peptidyl-carrier protein] + tryptamine = beta-alanyl-tryptamine + holo-[peptidyl-carrier protein] + H(+)

Direction not assertedBalance undeterminableRhea 73347

histamine + beta-alanine + ATP = carcinine + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 73351

beta-alanyl-[peptidyl-carrier protein] + histamine = carcinine + holo-[peptidyl-carrier protein] + H(+)

Direction not assertedBalance undeterminableRhea 73355

dopamine + beta-alanine + ATP = beta-alanyl-dopamine + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 73359

beta-alanyl-[peptidyl-carrier protein] + dopamine = beta-alanyl-dopamine + holo-[peptidyl-carrier protein] + H(+)

Direction not assertedBalance undeterminableRhea 73363

D-xylose(out) + 2 Na(+)(out) = D-xylose(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 73367

(R)-pantothenate(out) + 2 Na(+)(out) = (R)-pantothenate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 73371

biotin(out) + 2 Na(+)(out) = biotin(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 73375

(R)-lipoate(out) + 2 Na(+)(out) = (R)-lipoate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 73379

thiamine phosphate(out) + thiamine diphosphate(in) = thiamine phosphate(in) + thiamine diphosphate(out)

Direction not assertedBalancedTransportRhea 73383

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