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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Articles

Chemistry

Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

15,151–15,200 of 18,558 reactions from Rhea

2 indole-3-pyruvate + 2 ATP = didemethylasterriquinone D + 2 AMP + 2 diphosphate + H(+)
Direction not assertedBalancedRhea 72975
didemethylasterriquinone D + dimethylallyl diphosphate = asterriquinone C1 + diphosphate
Direction not assertedBalancedRhea 72979
harmol + dimethylallyl diphosphate = 6-(3-dimethylallyl)harmol + diphosphate
Direction not assertedBalancedRhea 72983
myo-inositol(out) + 2 Na(+)(out) = myo-inositol(in) + 2 Na(+)(in)
Direction not assertedBalancedTransportRhea 72987
scyllo-inositol(out) + 2 Na(+)(out) = scyllo-inositol(in) + 2 Na(+)(in)
Direction not assertedBalancedTransportRhea 72991
L-fucose(out) + 2 Na(+)(out) = L-fucose(in) + 2 Na(+)(in)
Direction not assertedBalancedTransportRhea 72995

an N-terminal L-tryptophanyl-L-alpha-aminoacyl-[peptide] + H2O = an N-terminal L-alpha-aminoacyl-[peptide] + L-tryptophan

Direction not assertedBalance undeterminableRhea 72999

anthranilate + L-tryptophan + 2 ATP = (R)-benzodiazepinedione + 2 AMP + 2 diphosphate + H(+)

Direction not assertedBalancedRhea 73003

D-arabinose 5-phosphate = glycolaldehyde + D-glyceraldehyde 3-phosphate

Direction not assertedBalancedRhea 73007

L-leucine(in) = L-leucine(out)

Right to leftBalancedTransportRhea 73011

D-leucine(in) = D-leucine(out)

Direction not assertedBalancedTransportRhea 73015

pregnenolone sulfate(out) = pregnenolone sulfate(in)

Direction not assertedBalancedTransportRhea 73023

Cd(2+)(out) + H(+)(out) = Cd(2+)(in) + H(+)(in)

Left to rightBalancedTransportRhea 73031

Co(2+)(out) + H(+)(out) = Co(2+)(in) + H(+)(in)

Left to rightBalancedTransportRhea 73035

Ni(2+)(out) + H(+)(out) = Ni(2+)(in) + H(+)(in)

Left to rightBalancedTransportRhea 73039

creatine(in) = creatine(out)

Right to leftBalancedTransportRhea 73043

guanidinoacetate(in) = guanidinoacetate(out)

Direction not assertedBalancedTransportRhea 73047

taurocholate(out) + hydrogencarbonate(in) = taurocholate(in) + hydrogencarbonate(out)

Direction not assertedBalancedTransportRhea 73051

estrone 3-sulfate(out) + hydrogencarbonate(in) = estrone 3-sulfate(in) + hydrogencarbonate(out)

Direction not assertedBalancedTransportRhea 73055

Mn(2+)(out) + Ca(2+)(in) = Mn(2+)(in) + Ca(2+)(out)

Direction not assertedBalancedTransportRhea 73059

Mn(2+)(in) + H(+)(out) = Mn(2+)(out) + H(+)(in)

Direction not assertedBalancedTransportRhea 73063

an N(4)-(oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc)-L-asparaginyl-[protein] + H2O = an oligosaccharide-(1->3)-[oligosaccharide-(1->6)]-beta-D-Man-(1->4)-D-GlcNAc + N(4)-(N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein]

Direction not assertedBalance undeterminableRhea 73067

apigenin + S-adenosyl-L-methionine = genkwanin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 73071

luteolin + S-adenosyl-L-methionine = luteolin 7-methyl ether + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 73075

scutellarein + S-adenosyl-L-methionine = scutellarein 7-methyl ether + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 73079

chrysoeriol + S-adenosyl-L-methionine = velutin + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 73083

FAD(in) + AMP(out) = FAD(out) + AMP(in)

Direction not assertedBalancedTransportRhea 73087

FMN(in) + AMP(out) = FMN(out) + AMP(in)

Direction not assertedBalancedTransportRhea 73091

AMP(out) + CoA(in) = AMP(in) + CoA(out)

Direction not assertedBalancedTransportRhea 73095

3'-dephospho-CoA(in) + AMP(out) = 3'-dephospho-CoA(out) + AMP(in)

Direction not assertedBalancedTransportRhea 73099

diosmetin + S-adenosyl-L-methionine = luteolin 4',7-dimethyl ether + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 73103

acacetin + S-adenosyl-L-methionine = apigenin 4',7-dimethyl ether + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 73107

scutellarein 4'-methyl ether + S-adenosyl-L-methionine = ladanein + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 73111

quercetin + S-adenosyl-L-methionine = rhamnetin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 73115

kaempferol + S-adenosyl-L-methionine = kaempferol 7-methyl ether + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 73119

isorhamnetin + S-adenosyl-L-methionine = rhamnacene + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 73123

4',7,8-trihydroxyflavone + S-adenosyl-L-methionine = 4',8-dihydroxy-7-methoxyflavone + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 73127

8-hydroxy-7-methoxyflavone + S-adenosyl-L-methionine = 7,8-dimethoxyflavone + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 73131

4',7,8-trihydroxyflavone + S-adenosyl-L-methionine = 4',7-dihydroxy-8-methoxyflavone + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 73135

lithocholate(out) = lithocholate(in)

Direction not assertedBalancedTransportRhea 73139

FAD(in) + CoA(out) = FAD(out) + CoA(in)

Direction not assertedBalancedTransportRhea 73143

FAD(in) + adenosine 3',5'-bisphosphate(out) = FAD(out) + adenosine 3',5'-bisphosphate(in)

Direction not assertedBalancedTransportRhea 73147

FMN(in) + CoA(out) = FMN(out) + CoA(in)

Direction not assertedBalancedTransportRhea 73151

FMN(in) + adenosine 3',5'-bisphosphate(out) = FMN(out) + adenosine 3',5'-bisphosphate(in)

Direction not assertedBalancedTransportRhea 73155

FMN(out) + NAD(+)(in) = FMN(in) + NAD(+)(out)

Direction not assertedBalancedTransportRhea 73159

FAD(out) + NAD(+)(in) = FAD(in) + NAD(+)(out)

Direction not assertedBalancedTransportRhea 73163

NAD(+)(in) + CoA(out) = NAD(+)(out) + CoA(in)

Direction not assertedBalancedTransportRhea 73167

adenosine 3',5'-bisphosphate(out) + NAD(+)(in) = adenosine 3',5'-bisphosphate(in) + NAD(+)(out)

Direction not assertedBalancedTransportRhea 73171

FMN(out) + ADP(in) = FMN(in) + ADP(out)

Direction not assertedBalancedTransportRhea 73175

scutellarein + S-adenosyl-L-methionine = scutellarein 4'-methyl ether + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 73179

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