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Reference

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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Proteins
Interactions
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Reactions
Reach

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Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

15,101–15,150 of 18,558 reactions from Rhea

7-carboxymellein + L-phenylalanine + ATP = ochratoxin B + ADP + phosphate + H(+)
Direction not assertedBalancedRhea 72775
ochratoxin B + FADH2 + chloride + O2 = ochratoxin A + FAD + 2 H2O
Direction not assertedBalancedRhea 72779
N-carbamoyl-L-methionine + H2O + 2 H(+) = L-methionine + NH4(+) + CO2
Direction not assertedBalancedRhea 72783
N-carbamoyl-L-cysteine + H2O + 2 H(+) = L-cysteine + NH4(+) + CO2
Direction not assertedBalancedRhea 72787
(4E,15E)-bilirubin IXalpha C8-beta-D-glucuronoside(out) = (4E,15E)-bilirubin IXalpha C8-beta-D-glucuronoside(in)
Direction not assertedBalancedTransportRhea 72791
bilirubin IXalpha bis-beta-D-glucuronoside(out) = bilirubin IXalpha bis-beta-D-glucuronoside(in)
Direction not assertedBalancedTransportRhea 72795

L-homoarginine(in) + L-arginine(out) = L-homoarginine(out) + L-arginine(in)

Direction not assertedBalancedTransportRhea 72799

N(omega)-methyl-L-arginine(in) + L-arginine(out) = N(omega)-methyl-L-arginine(out) + L-arginine(in)

Direction not assertedBalancedTransportRhea 72803

L-histidine(out) = L-histidine(in)

Direction not assertedBalancedTransportRhea 72807

N(omega),N(omega)-dimethyl-L-arginine(in) + L-arginine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-arginine(in)

Direction not assertedBalancedTransportRhea 72811

N(omega),N(omega)-dimethyl-L-arginine(in) + L-lysine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-lysine(in)

Direction not assertedBalancedTransportRhea 72815

N(omega),N(omega)-dimethyl-L-arginine(in) + L-ornithine(out) = N(omega),N(omega)-dimethyl-L-arginine(out) + L-ornithine(in)

Direction not assertedBalancedTransportRhea 72819

N-carbamoyl-L-tryptophan + H2O + 2 H(+) = L-tryptophan + NH4(+) + CO2

Direction not assertedBalancedRhea 72823

N-carbamoyl-L-alanine + H2O + 2 H(+) = L-alanine + NH4(+) + CO2

Direction not assertedBalancedRhea 72827

3',3'-cGAMP + H2O = G[3'-5']pAp[3'] + H(+)

Direction not assertedBalancedRhea 72831

3',3'-cUAMP + H2O = U[3'-5']pAp[3'] + H(+)

Direction not assertedBalancedRhea 72835

ADP(out) + CoA(in) = ADP(in) + CoA(out)

Direction not assertedBalancedTransportRhea 72839

3'-dephospho-CoA(in) + ADP(out) = 3'-dephospho-CoA(out) + ADP(in)

Direction not assertedBalancedTransportRhea 72843

adenosine 3',5'-bisphosphate(in) + ADP(out) = adenosine 3',5'-bisphosphate(out) + ADP(in)

Direction not assertedBalancedTransportRhea 72847

AMP(in) + ADP(out) = AMP(out) + ADP(in)

Direction not assertedBalancedTransportRhea 72851

dADP(in) + ADP(out) = dADP(out) + ADP(in)

ReversibleBalancedTransportRhea 72855

3',3',3'-c-tri-AMP + H2O = A[3'-5']pA[3'-5']pAp[3'] + H(+)

Direction not assertedBalancedRhea 72859

3',3',3'-cAAG + H2O = G[3'-5']pA[3'-5']pAp[3'] + H(+)

Direction not assertedBalancedRhea 72863

3',3',3'-cAAG + H2O = A[3'-5']pG[3'-5']pAp[3'] + H(+)

Direction not assertedBalancedRhea 72867

anthocyanin A3 + malonyl-CoA = anthocyanin A5 + CoA

Direction not assertedBalancedRhea 72871

anthocyanin A7 + malonyl-CoA = anthocyanin A9 + CoA

Direction not assertedBalancedRhea 72875

(1R)-(2-amino-1-hydroxyethyl)phosphonate = phosphonoacetaldehyde + NH4(+)

Direction not assertedBalancedRhea 72879

2 3-phenylpyruvate + 2 ATP = polyporic acid + 2 AMP + 2 diphosphate + H(+)

Direction not assertedBalancedRhea 72883

polyporic acid + reduced [NADPH--hemoprotein reductase] + O2 = ascocorynin + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 72887

acetylcholine(out) + 2 H(+)(in) = acetylcholine(in) + 2 H(+)(out)

Left to rightBalancedTransportRhea 72891

6 malonyl-CoA + 2 acetyl-CoA + 2 S-adenosyl-L-methionine + 3 H(+) = 4-O-demethylbarbatate + 2 S-adenosyl-L-homocysteine + 6 CO2 + 8 CoA + H2O

Direction not assertedBalancedRhea 72895

4-O-demethylbarbatate + S-adenosyl-L-methionine = proatranorin I + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 72899

butyrolactone II + dimethylallyl diphosphate = butyrolactone I + diphosphate

Direction not assertedBalancedRhea 72903

D-mannose(out) + Na(+)(out) = D-mannose(in) + Na(+)(in)

Left to rightBalancedTransportRhea 72907

proatranorin III + S-adenosyl-L-methionine = atranorin + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 72911

D-fructopyranose(out) + Na(+)(out) = D-fructopyranose(in) + Na(+)(in)

Left to rightBalancedTransportRhea 72915

4-O-demethylbarbatate + reduced [NADPH--hemoprotein reductase] + O2 = proatranorin II + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 72919

proatranorin II + reduced [NADPH--hemoprotein reductase] + O2 = proatranorin III + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 72923

proatranorin I + reduced [NADPH--hemoprotein reductase] + O2 = proatranorin IV + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 72927

proatranorin IV + reduced [NADPH--hemoprotein reductase] + O2 = atranorin + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 72931

(S)-lactate(out) + 2 Na(+)(out) = (S)-lactate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72935

propanoate(out) + 2 Na(+)(out) = propanoate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72939

pyruvate(out) + 2 Na(+)(out) = pyruvate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72943

acetate(out) + 2 Na(+)(out) = acetate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72947

butanoate(out) + 2 Na(+)(out) = butanoate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72951

nicotinate(out) + 2 Na(+)(out) = nicotinate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72955

(R)-3-hydroxybutanoate(out) + 2 Na(+)(out) = (R)-3-hydroxybutanoate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72959

acetoacetate(out) + 2 Na(+)(out) = acetoacetate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72963

4-methyl-2-oxopentanoate(out) + 2 Na(+)(out) = 4-methyl-2-oxopentanoate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72967

5-oxo-L-proline(out) + 2 Na(+)(out) = 5-oxo-L-proline(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72971

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