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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Chemistry

Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

15,001–15,050 of 18,558 reactions from Rhea

iodide(in) + hydrogencarbonate(out) = iodide(out) + hydrogencarbonate(in)
Direction not assertedBalancedTransportRhea 72375
iodide(in) + chloride(out) = iodide(out) + chloride(in)
Direction not assertedBalancedTransportRhea 72379
urate(in) + Na(+)(out) = urate(out) + Na(+)(in)
Direction not assertedBalancedTransportRhea 72383
2 hydrogencarbonate(out) + sulfate(in) = 2 hydrogencarbonate(in) + sulfate(out)
Direction not assertedBalancedTransportRhea 72387
oxalate(in) + 2 hydrogencarbonate(out) = oxalate(out) + 2 hydrogencarbonate(in)
Direction not assertedBalancedTransportRhea 72391
K(+)(out) + 2 chloride(out) + Na(+)(out) = K(+)(in) + 2 chloride(in) + Na(+)(in)
Left to rightBalancedTransportRhea 72395

estrone 3-sulfate(in) + 2-oxoglutarate(out) = estrone 3-sulfate(out) + 2-oxoglutarate(in)

Direction not assertedBalancedTransportRhea 72399

urate(in) + 2-oxoglutarate(out) = urate(out) + 2-oxoglutarate(in)

Direction not assertedBalancedTransportRhea 72403

Li(+)(out) + H(+)(in) = Li(+)(in) + H(+)(out)

Direction not assertedBalancedTransportRhea 72407

inulobiose = alpha-D-fructofuranose-beta-D-fructofuranose 2',1:2,3'-dianhydride + H2O

Direction not assertedBalancedRhea 72411

Li(+)(in) + Na(+)(out) = Li(+)(out) + Na(+)(in)

Direction not assertedBalancedTransportRhea 72415

(E)-4-coumarate + ATP + H(+) = (E)-4-coumaroyl-AMP + diphosphate

Direction not assertedBalancedRhea 72419

(E)-4-coumaroyl-AMP + CoA = (E)-4-coumaroyl-CoA + AMP + H(+)

Direction not assertedBalancedRhea 72423

K(+)(in) + chloride(in) = K(+)(out) + chloride(out)

Direction not assertedBalancedTransportRhea 72427

(E)-caffeate + ATP + H(+) = (E)-caffeoyl-AMP + diphosphate

Direction not assertedBalancedRhea 72431

(E)-caffeoyl-AMP + CoA = (E)-caffeoyl-CoA + AMP + H(+)

Direction not assertedBalancedRhea 72435

(E)-ferulate + ATP + H(+) = (E)-feruloyl-AMP + diphosphate

Direction not assertedBalancedRhea 72439

(E)-feruloyl-AMP + CoA = (E)-feruloyl-CoA + AMP + H(+)

Direction not assertedBalancedRhea 72443

estrone 3-sulfate(out) + a dicarboxylate(in) = estrone 3-sulfate(in) + a dicarboxylate(out)

Direction not assertedBalance undeterminableTransportRhea 72447

dehydroepiandrosterone 3-sulfate(out) + a dicarboxylate(in) = dehydroepiandrosterone 3-sulfate(in) + a dicarboxylate(out)

Direction not assertedBalance undeterminableTransportRhea 72451

fumarate(out) + 3 H(+)(out) = fumarate(in) + 3 H(+)(in)

Direction not assertedBalancedTransportRhea 72455

fumarate(in) + L-aspartate(out) = fumarate(out) + L-aspartate(in)

Direction not assertedBalancedTransportRhea 72459

L-threonyl-[protein] + NAD(+) = O-(ADP-D-ribosyl)-L-threonyl-[protein] + nicotinamide + H(+)

Direction not assertedBalance undeterminableRhea 72463

6 malonyl-CoA + 2 acetyl-CoA + 5 H(+) = o-orsellinate depside + 6 CO2 + 8 CoA + H2O

Direction not assertedBalancedRhea 72467

D-threo-isocitrate(in) + citrate(out) = D-threo-isocitrate(out) + citrate(in)

Direction not assertedBalancedTransportRhea 72471

cis-aconitate(in) + citrate(out) = cis-aconitate(out) + citrate(in)

Direction not assertedBalancedTransportRhea 72475

trans-aconitate(in) + citrate(out) = trans-aconitate(out) + citrate(in)

Direction not assertedBalancedTransportRhea 72479

(S)-malate(in) + citrate(out) = (S)-malate(out) + citrate(in)

Direction not assertedBalancedTransportRhea 72483

phosphoenolpyruvate(in) + citrate(out) = phosphoenolpyruvate(out) + citrate(in)

Direction not assertedBalancedTransportRhea 72487

maleate(in) + citrate(out) = maleate(out) + citrate(in)

Direction not assertedBalancedTransportRhea 72491

prostaglandin E2(out) + glutarate(in) = prostaglandin E2(in) + glutarate(out)

Direction not assertedBalancedTransportRhea 72495

prostaglandin E2(out) + 2-oxoglutarate(in) = prostaglandin E2(in) + 2-oxoglutarate(out)

Direction not assertedBalancedTransportRhea 72499

prostaglandin F2alpha(out) + glutarate(in) = prostaglandin F2alpha(in) + glutarate(out)

Direction not assertedBalancedTransportRhea 72503

prostaglandin F2alpha(out) + 2-oxoglutarate(in) = prostaglandin F2alpha(in) + 2-oxoglutarate(out)

Direction not assertedBalancedTransportRhea 72507

(R)-carnitine(out) + 2-oxoglutarate(in) = (R)-carnitine(in) + 2-oxoglutarate(out)

Direction not assertedBalancedTransportRhea 72511

glutarate(in) + (R)-carnitine(out) = glutarate(out) + (R)-carnitine(in)

Direction not assertedBalancedTransportRhea 72515

phenazine-1,6-dicarboxylate + NADH + O2 + 2 H(+) = 6-hydroxyphenazine-1-carboxylate + CO2 + NAD(+) + H2O

Direction not assertedBalancedRhea 72519

1,6-dihydroxyphenazine + S-adenosyl-L-methionine = 1-hydroxy-6-methoxyphenazine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 72523

1-hydroxy-6-methoxyphenazine + S-adenosyl-L-methionine = 1,6-dimethoxyphenazine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 72527

methyl beta-D-galactoside(out) + ATP + H2O = methyl beta-D-galactoside(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 72531

vanillin + NADP(+) + H2O = vanillate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 72535

3,4-dihydroxybenzaldehyde + NADP(+) + H2O = 3,4-dihydroxybenzoate + NADPH + 2 H(+)

Direction not assertedBalancedRhea 72539

dehydroepiandrosterone 3-sulfate(out) + 2-oxoglutarate(in) = dehydroepiandrosterone 3-sulfate(in) + 2-oxoglutarate(out)

Direction not assertedBalancedTransportRhea 72543

taurocholate(out) + 2-oxoglutarate(in) = taurocholate(in) + 2-oxoglutarate(out)

Direction not assertedBalancedTransportRhea 72547

urate(in) + glutarate(out) = urate(out) + glutarate(in)

Direction not assertedBalancedTransportRhea 72551

propanoate(in) + estrone 3-sulfate(out) = propanoate(out) + estrone 3-sulfate(in)

Direction not assertedBalancedTransportRhea 72555

pentanoate(in) + estrone 3-sulfate(out) = pentanoate(out) + estrone 3-sulfate(in)

Direction not assertedBalancedTransportRhea 72559

dehydroepiandrosterone 3-sulfate(in) + butanoate(out) = dehydroepiandrosterone 3-sulfate(out) + butanoate(in)

Direction not assertedBalancedTransportRhea 72563

propanoate(out) + dehydroepiandrosterone 3-sulfate(in) = propanoate(in) + dehydroepiandrosterone 3-sulfate(out)

Direction not assertedBalancedTransportRhea 72567

pentanoate(out) + dehydroepiandrosterone 3-sulfate(in) = pentanoate(in) + dehydroepiandrosterone 3-sulfate(out)

Direction not assertedBalancedTransportRhea 72571

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