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Subsystem: Bile acid biosynthesis Remove
101–150 of 256 reactions in Bile acid biosynthesis
cholesterol[r] + H+[r] + NADPH[r] + O2[r] = 20-hydroxycholesterol[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.99.38Human-GEM MAR01781
20-hydroxycholesterol[r] + NAD+[r] = 7alpha-hydroxycholest-4-en-3-one[r] + H+[r] + NADH[r]
Left to rightBalancedEC 1.1.1.145, 5.3.3.1Human-GEM MAR01783
cholesterol[m] + H+[m] + NADPH[m] + O2[m] = 26-hydroxycholesterol[m] + H2O[m] + NADP+[m]
Left to rightBalancedEC 1.14.99.38Human-GEM MAR01784
cholesterol[r] + H+[r] + NADPH[r] + O2[r] = 26-hydroxycholesterol[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.99.38Human-GEM MAR01785
cholesterol[c] + H+[c] + NADPH[c] + O2[c] = 26-hydroxycholesterol[c] + H2O[c] + NADP+[c]
Left to right
26-hydroxycholesterol[r] + NAD+[r] = 7alpha-hydroxycholest-4-en-3-one[r] + H+[r] + NADH[r]
Left to rightBalancedHuman-GEM MAR01787
26-hydroxycholesterol[m] + NADP+[m] = 3beta-hydroxy-5-cholestenal[m] + H+[m] + NADPH[m]
ReversibleBalancedEC 1.14.15.15Human-GEM MAR01790
3beta-hydroxy-5-cholestenal[m] + H2O[m] + NADP+[m] = 3beta-hydroxy-5-cholestene-27-oate[m] + 2 H+[m] + NADPH[m]
ReversibleBalancedEC 1.14.15.15Human-GEM MAR01792
3beta-hydroxy-5-cholestene-27-oate[m] + H+[m] + NADPH[m] + O2[m] = 3beta,7alpha-dihydroxy-5-cholestenoate[m] + H2O[m] + NADP+[m]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01794
3beta,7alpha-dihydroxy-5-cholestenoate[m] + NADP+[m] = 7alpha-hydroxy-3-oxo-4-cholestenoic acid[m] + H+[m] + NADPH[m]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01796
26-hydroxycholesterol[c] + H+[c] + NADPH[c] + O2[c] = cholest-5-ene-3beta,7alpha,27-triol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.13.-Human-GEM MAR01797
26-hydroxycholesterol[m] + H+[m] + NADPH[m] + O2[m] = cholest-5-ene-3beta,7alpha,27-triol[m] + H2O[m] + NADP+[m]
Left to rightBalancedEC 1.14.13.-Human-GEM MAR01798
cholest-5-ene-3beta,7alpha,27-triol[m] + H+[m] + 2 NADPH[m] + 2 O2[m] = 3beta,7alpha-dihydroxy-5-cholestenoate[m] + 3 H2O[m] + 2 NADP+[m]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01800
5beta-cholestan-3alpha,7alpha,12alpha-triol[m] + H+[m] + NADPH[m] + O2[m] = 5beta-cholestane-3alpha,7alpha,12alpha,27-tetraol[m] + H2O[m] + NADP+[m]
ReversibleBalancedEC 1.14.13.-Human-GEM MAR01802
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al[c] + H+[c] + NADH[c] = 5beta-cholestane-3alpha,7alpha,12alpha,27-tetraol[c] + NAD+[c]
ReversibleBalancedEC 1.14.15.15Human-GEM MAR01803
5beta-cholestane-3alpha,7alpha,12alpha,27-tetraol[c] + H+[c] + NADPH[c] + O2[c] = 5beta-cholestane-3alpha,7alpha,12alpha,27,27-pentaol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.13.-Human-GEM MAR01804
5beta-cholestane-3alpha,7alpha,12alpha,27-tetraol[m] + H+[m] + NADPH[m] + O2[m] = 5beta-cholestane-3alpha,7alpha,12alpha,27,27-pentaol[m] + H2O[m] + NADP+[m]
Left to rightBalancedEC 1.14.13.-Human-GEM MAR01805
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al[m] + H+[m] + NADH[m] = 5beta-cholestane-3alpha,7alpha,12alpha,27-tetraol[m] + NAD+[m]
ReversibleBalancedEC 1.14.15.15Human-GEM MAR01806
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al[m] + H2O[m] = 5beta-cholestane-3alpha,7alpha,12alpha,27,27-pentaol[m]
ReversibleBalancedEC 1.14.15.15Human-GEM MAR01807
5beta-cholestan-3alpha,7alpha,12alpha-triol[r] + H+[r] + NADPH[r] + O2[r] = 5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.55Human-GEM MAR01810
5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol[r] + H+[r] + NADPH[r] + O2[r] = 5beta-cholestane-3alpha,7alpha,12alpha,24s,25-pentol[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.15.15Human-GEM MAR01811
3alpha,7alpha,12alpha,25-tetrahydroxy-5beta-cholestane-24-one[r] + H+[r] + NADPH[r] = 5beta-cholestane-3alpha,7alpha,12alpha,24s,25-pentol[r] + NADP+[r]
ReversibleBalancedEC 1.1.1.-Human-GEM MAR01813
5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol[r] + H+[r] + NADPH[r] + O2[r] = 5beta-cholestane-3alpha,7alpha,12alpha,23,25-pentol[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.55Human-GEM MAR01815
5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol[r] + H+[r] + NADPH[r] + O2[r] = 5beta-cholestane-3alpha,7alpha,12alpha,24r,25-pentol[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.55Human-GEM MAR01817
5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol[r] + H+[r] + NADPH[r] + O2[r] = 5beta-cholestane-3alpha,7alpha,12alpha,25,27-pentol[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.55Human-GEM MAR01819
cholate[c] + H2O[c] + NADP+[c] = 3alpha,12alpha-dihydroxy-5beta-cholanate[c] + H+[c] + NADPH[c] + O2[c]
Left to rightBalancedEC 1.14.14.23Human-GEM MAR01830
cholate[r] + H2O[r] + NADP+[r] = 3alpha,12alpha-dihydroxy-5beta-cholanate[r] + H+[r] + NADPH[r] + O2[r]
Left to rightBalancedEC 1.14.14.23Human-GEM MAR01831
3alpha,12alpha-dihydroxy-5beta-cholanate[c] + ATP[c] + CoA[c] = AMP[c] + deoxycholoyl-CoA[c] + PPi[c]
Left to rightBalancedEC 6.2.1.7Human-GEM MAR01832
3alpha,12alpha-dihydroxy-5beta-cholanate[r] + ATP[r] + CoA[r] = AMP[r] + deoxycholoyl-CoA[r] + PPi[r]
Left to rightBalancedEC 6.2.1.7Human-GEM MAR01833
3alpha,12alpha-dihydroxy-5beta-cholanate[c] + glycine[c] + H+[c] = glycodeoxycholate[c] + H2O[c]
ReversibleBalancedEC 3.5.1.24Human-GEM MAR01834
CoA[c] + H+[c] + taurodeoxycholate[c] = deoxycholoyl-CoA[c] + taurine[c]
ReversibleBalancedEC 2.3.1.65Human-GEM MAR01835
CoA[x] + H+[x] + taurodeoxycholate[x] = deoxycholoyl-CoA[x] + taurine[x]
ReversibleBalancedEC 2.3.1.65Human-GEM MAR01837
2 H+[c] + lithocholate[c] + NADPH[c] + O2[c] = H2O[c] + hyodeoxycholate[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.57Human-GEM MAR01838
H+[c] + lithocholate[c] + NADPH[c] + O2[c] = 3alpha,12alpha-dihydroxy-5beta-cholanate[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.139Human-GEM MAR01839
H+[r] + lithocholate[r] + NADPH[r] + O2[r] = 3alpha,12alpha-dihydroxy-5beta-cholanate[r] + H2O[r] + NADP+[r]
Left to rightBalancedEC 1.14.14.139Human-GEM MAR01840
ATP[c] + lithocholate[c] + taurine[c] = AMP[c] + H+[c] + PPi[c] + taurolithocholate[c]
Left to rightBalancedEC 6.2.1.-, 2.3.1.65Human-GEM MAR01841
ATP[x] + lithocholate[x] + taurine[x] = AMP[x] + H+[x] + PPi[x] + taurolithocholate[x]
Left to rightBalancedEC 6.2.1.-, 2.3.1.65Human-GEM MAR01842
PAPS[c] + taurolithocholate[c] = H+[c] + PAP[c] + sulfotaurolithocholate[c]
ReversibleBalancedEC 2.8.2.14Human-GEM MAR01843
ATP[c] + glycine[c] + lithocholate[c] = AMP[c] + glycolithocholate[c] + H+[c] + PPi[c]
Left to rightBalancedEC 6.2.1.-, 2.3.1.65Human-GEM MAR01844
ATP[x] + glycine[x] + lithocholate[x] = AMP[x] + glycolithocholate[x] + H+[x] + PPi[x]
Left to rightBalancedEC 6.2.1.-, 2.3.1.65Human-GEM MAR01845
glycolithocholate[c] + PAPS[c] = H+[c] + PAP[c] + sulfoglycolithocholate[c]
Left to rightBalancedEC 2.8.2.14Human-GEM MAR01846
25-hydroxycholesterol[r] + NADP+[r] = 7alpha-hydroxycholest-4-en-3-one[r] + H+[r] + NADPH[r]
ReversibleBalancedEC 1.1.1.181Human-GEM MAR02184
7alpha-hydroxycholesterol[c] + NAD+[c] = 7alpha-hydroxycholest-4-en-3-one[c] + H+[c] + NADH[c]
ReversibleBalancedEC 5.3.3.1Human-GEM MAR02860
20-hydroxycholesterol[m] + NAD+[m] = 7alpha-hydroxycholest-4-en-3-one[m] + H+[m] + NADH[m]
ReversibleBalancedEC 5.3.3.1Human-GEM MAR02881
5beta-cholestane-3alpha,7alpha,27-triol[c] + NAD+[c] = 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al[c] + H+[c] + NADH[c]
ReversibleBalancedEC 1.5.3.13, 1.5.3.14, 1.5.3.15, 1.5.3.16, 1.5.3.17Human-GEM MAR02883
5beta-cholestane-3alpha,7alpha,26-triol[m] + NAD+[m] = 3alpha,7alpha-dihydroxy-5beta-cholestan-26-al[m] + H+[m] + NADH[m]
ReversibleBalancedEC 1.5.3.13, 1.5.3.14, 1.5.3.15, 1.5.3.16, 1.5.3.17Human-GEM MAR02885
5beta-cholestan-3alpha,7alpha,12alpha-triol[c] + H+[c] + NADPH[c] + O2[c] = 5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.55Human-GEM MAR02887
3alpha,7alpha-dihydroxy-5beta-cholestan-26-al[c] + H2O[c] + NADP+[c] = 3alpha,7alpha-dihydroxy-5beta-cholestanate[c] + 2 H+[c] + NADPH[c]
ReversibleBalancedEC 5.3.3.8Human-GEM MAR02889
3alpha,7alpha-dihydroxy-5beta-cholestan-26-al[m] + H2O[m] + NADP+[m] = 3alpha,7alpha-dihydroxy-5beta-cholestanate[m] + 2 H+[m] + NADPH[m]
ReversibleBalancedEC 1.14.14.55Human-GEM MAR02891
5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol[c] + H+[c] + NADPH[c] + O2[c] = 5beta-cholestane-3alpha,7alpha,12alpha,23,25-pentol[c] + H2O[c] + NADP+[c]
Left to rightBalancedEC 1.14.14.55Human-GEM MAR02893