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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
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Articles

Chemistry

Reactions
Reach

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Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

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Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

14,901–14,950 of 18,558 reactions from Rhea

glutathione(out) + 3 Na(+)(out) = glutathione(in) + 3 Na(+)(in)
Direction not assertedBalancedTransportRhea 71975
(2E,6E,10E,14E)-geranylfarnesyl diphosphate = fusoxypene A + diphosphate
Direction not assertedBalancedRhea 71979
(2E,6E,10E,14E)-geranylfarnesyl diphosphate = fusoxypene B + diphosphate
Direction not assertedBalancedRhea 71983
(2E,6E,10E,14E)-geranylfarnesyl diphosphate = fusoxypene C + diphosphate
Direction not assertedBalancedRhea 71987
(2E,6E,10E,14E)-geranylfarnesyl diphosphate = (-)-astellatene + diphosphate
Direction not assertedBalancedRhea 71991
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = preaspterpenacid acid I + diphosphate
Direction not assertedBalancedRhea 71995
preaspterpenacid acid I + reduced [NADPH--hemoprotein reductase] + O2 = preaspterpenacid acid II + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 71999

urate(out) + (S)-lactate(in) = urate(in) + (S)-lactate(out)

Left to rightBalancedTransportRhea 72003

urate(out) + succinate(in) = urate(in) + succinate(out)

Left to rightBalancedTransportRhea 72007

urate(out) + glutathione(in) = urate(in) + glutathione(out)

Left to rightBalancedTransportRhea 72011

malate + 6 malonyl-CoA + acetyl-CoA + 2 AH2 + 2 S-adenosyl-L-methionine + 5 NADPH + 9 H(+) = trihazone A + 2 A + 2 S-adenosyl-L-homocysteine + 6 CO2 + 5 NADP(+) + 7 CoA + 6 H2O

Direction not assertedBalancedRhea 72015

trihazone A + 2-oxoglutarate + O2 + H(+) = trihazone D + succinate + 2 CO2 + H2O

Direction not assertedBalancedRhea 72019

nicotinate(in) + urate(out) = nicotinate(out) + urate(in)

Left to rightBalancedTransportRhea 72023

(E)-sinapaldehyde + L-proline = (E)-nesocodin (alcohol-form) + H2O

Direction not assertedBalancedRhea 72027

(E)-sinapyl alcohol + O2 = (E)-sinapaldehyde + H2O2

Direction not assertedBalancedRhea 72031

phosphate(in) + ATP(out) + 2 H(+)(out) = phosphate(out) + ATP(in) + 2 H(+)(in)

Direction not assertedBalancedTransportRhea 72035

orotate(out) + nicotinate(in) = orotate(in) + nicotinate(out)

Direction not assertedBalancedTransportRhea 72039

orotate(out) + L-glutamate(in) = orotate(in) + L-glutamate(out)

Direction not assertedBalancedTransportRhea 72043

D-allo-threonine + D-leucine + D-alanine + L-proline + 2 L-leucine + A = fusahexin + AH2 + 6 H2O

Direction not assertedBalancedRhea 72047

butanoate(out) + estrone 3-sulfate(in) = butanoate(in) + estrone 3-sulfate(out)

Direction not assertedBalancedTransportRhea 72051

glycodeoxycholate(out) + 2 Na(+)(out) = glycodeoxycholate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72055

glycochenodeoxycholate(out) + 2 Na(+)(out) = glycochenodeoxycholate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72059

glycoursodeoxycholate(out) + 2 Na(+)(out) = glycoursodeoxycholate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72063

(2S)-2-aminobutanoate + L-glutamate + ATP = gamma-L-glutamyl-(2S)-2-aminobutanoate + ADP + phosphate + H(+)

Left to rightBalancedRhea 72067

L-histidyl-[protein] + NAD(+) = N(tele)-(ADP-D-ribosyl)-L-histidyl-[protein] + nicotinamide + H(+)

Left to rightBalance undeterminableRhea 72071

gamma-L-glutamyl-(2S)-2-aminobutanoate + glycine + ATP = ophthalmate + ADP + phosphate + H(+)

Left to rightBalancedRhea 72075

selenate(out) + 3 Na(+)(out) = selenate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 72079

ADP-alpha-D-ribose 1'',2''-cyclic phosphate + H2O = ADP-alpha-D-ribose 1''-phosphate + H(+)

Direction not assertedBalancedRhea 72083

taurodeoxycholate(out) + 2 Na(+)(out) = taurodeoxycholate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72087

(R)-carnitine(out) + Na(+)(out) = (R)-carnitine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 72091

(S)-carnitine(out) + Na(+)(out) = (S)-carnitine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 72095

O-acetyl-(R)-carnitine(out) + Na(+)(out) = O-acetyl-(R)-carnitine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 72099

O-propanoyl-(R)-carnitine(out) + Na(+)(out) = O-propanoyl-(R)-carnitine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 72103

an O-acyl-(R)-carnitine(out) + Na(+)(out) = an O-acyl-(R)-carnitine(in) + Na(+)(in)

Direction not assertedBalance undeterminableTransportRhea 72107

L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(out) + Na(+)(out) = L-glutamyl-L-arginyl-glycyl-L-methionyl-L-threonine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 72111

glycine betaine(out) + Na(+)(out) = glycine betaine(in) + Na(+)(in)

Left to rightBalancedTransportRhea 72115

glycine betaine(out) + (R)-carnitine(in) = glycine betaine(in) + (R)-carnitine(out)

Direction not assertedBalancedTransportRhea 72119

O-butanoyl-(R)-carnitine(out) + Na(+)(out) = O-butanoyl-(R)-carnitine(in) + Na(+)(in)

Direction not assertedBalancedTransportRhea 72123

agmatine(in) + H(+)(out) = agmatine(out) + H(+)(in)

ReversibleBalancedTransportRhea 72127

agmatine(out) = agmatine(in)

ReversibleBalancedTransportRhea 72131

putrescine(out) = putrescine(in)

Direction not assertedBalancedTransportRhea 72135

estrone 3-sulfate(in) + H(+)(out) = estrone 3-sulfate(out) + H(+)(in)

Direction not assertedBalancedTransportRhea 72139

GTP + AH2 + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-GTP + 5'-deoxyadenosine + L-methionine + A + H2O + H(+)

Direction not assertedBalancedRhea 72143

UTP + AH2 + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-UTP + 5'-deoxyadenosine + L-methionine + A + H2O + H(+)

Direction not assertedBalancedRhea 72147

estrone 3-sulfate(out) + glutarate(in) = estrone 3-sulfate(in) + glutarate(out)

Direction not assertedBalancedTransportRhea 72151

17beta-estradiol 17-O-(beta-D-glucuronate)(out) + glutarate(in) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + glutarate(out)

Direction not assertedBalancedTransportRhea 72155

taurocholate(out) + glutarate(in) = taurocholate(in) + glutarate(out)

Direction not assertedBalancedTransportRhea 72159

O-butanoyl-(R)-carnitine(out) + chloride(out) + 2 Na(+)(out) = O-butanoyl-(R)-carnitine(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72163

taurohyodeoxycholate(out) + 2 Na(+)(out) = taurohyodeoxycholate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72167

taurohyocholate(out) + 2 Na(+)(out) = taurohyocholate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 72171

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