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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

14,851–14,900 of 18,558 reactions from Rhea

acetoacetate(out) + H(+)(out) = acetoacetate(in) + H(+)(in)
ReversibleBalancedTransportRhea 71775
4-methyl-2-oxopentanoate(out) + H(+)(out) = 4-methyl-2-oxopentanoate(in) + H(+)(in)
Direction not assertedBalancedTransportRhea 71779
3-methyl-2-oxobutanoate(out) + H(+)(out) = 3-methyl-2-oxobutanoate(in) + H(+)(in)
Direction not assertedBalancedTransportRhea 71783
2-oxoadipate + O2 = (R)-2-hydroxyglutarate + CO2
Direction not assertedBalancedRhea 71787
(R)-lactate(in) + H(+)(in) = (R)-lactate(out) + H(+)(out)
Direction not assertedBalancedTransportRhea 71791
(R)-3-hydroxybutanoate(out) + H(+)(out) = (R)-3-hydroxybutanoate(in) + H(+)(in)
ReversibleBalancedTransportRhea 71795
Ca(2+)(in) + H(+)(out) = Ca(2+)(out) + H(+)(in)

Direction not assertedBalancedTransportRhea 71799

acetate(out) + H(+)(out) = acetate(in) + H(+)(in)

ReversibleBalancedTransportRhea 71803

a 2'-deoxyguanosine in DNA + NAD(+) = an N(2)-(ADP-L-ribosyl)-2'-deoxyguanosine in DNA + nicotinamide + H(+)

Direction not assertedBalance undeterminableRhea 71807

3,3',5-triiodo-L-thyronine(out) = 3,3',5-triiodo-L-thyronine(in)

ReversibleBalancedTransportRhea 71811

3,3',5'-triiodo-L-thyronine(out) = 3,3',5'-triiodo-L-thyronine(in)

Left to rightBalancedTransportRhea 71815

L-thyroxine(out) = L-thyroxine(in)

ReversibleBalancedTransportRhea 71819

3,3'-diiodo-L-thyronine(out) = 3,3'-diiodo-L-thyronine(in)

Direction not assertedBalancedTransportRhea 71823

arsenate(in) + H(+)(in) = arsenate(out) + H(+)(out)

Direction not assertedBalancedTransportRhea 71827

creatine(out) + chloride(out) + 2 Na(+)(out) = creatine(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71831

estrone 3-sulfate(out) = estrone 3-sulfate(in)

Left to rightBalancedTransportRhea 71835

dehydroepiandrosterone 3-sulfate(out) = dehydroepiandrosterone 3-sulfate(in)

Left to rightBalancedTransportRhea 71839

tauroursodeoxycholate(out) = tauroursodeoxycholate(in)

Direction not assertedBalancedTransportRhea 71843

glycoursodeoxycholate(out) = glycoursodeoxycholate(in)

Direction not assertedBalancedTransportRhea 71847

glycocholate(out) = glycocholate(in)

Right to leftBalancedTransportRhea 71851

taurochenodeoxycholate(out) = taurochenodeoxycholate(in)

Direction not assertedBalancedTransportRhea 71855

glycochenodeoxycholate(out) = glycochenodeoxycholate(in)

Direction not assertedBalancedTransportRhea 71859

taurodeoxycholate(out) = taurodeoxycholate(in)

Direction not assertedBalancedTransportRhea 71863

glycodeoxycholate(out) = glycodeoxycholate(in)

Direction not assertedBalancedTransportRhea 71867

(S)-3-hydroxybutanoate(out) + H(+)(out) = (S)-3-hydroxybutanoate(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 71871

taurocholate(out) + 2 Na(+)(out) = taurocholate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71875

2'-deoxyguanosine + NAD(+) = N(2)-(ADP-D-ribosyl)-2'-deoxyguanosine + nicotinamide + H(+)

Direction not assertedBalancedRhea 71879

GMP + NAD(+) = N(2)-(ADP-D-ribosyl)-GMP + nicotinamide + H(+)

Direction not assertedBalancedRhea 71883

GTP + NAD(+) = N(2)-(ADP-D-ribosyl)-GTP + nicotinamide + H(+)

Direction not assertedBalancedRhea 71887

dGMP + NAD(+) = N(2)-(ADP-D-ribosyl)-dGMP + nicotinamide + H(+)

Direction not assertedBalancedRhea 71891

dGTP + NAD(+) = N(2)-(ADP-D-ribosyl)-dGTP + nicotinamide + H(+)

Direction not assertedBalancedRhea 71895

3',5'-cyclic GMP + NAD(+) = N(2)-(ADP-D-ribosyl)-3',5'-cyclic GMP + nicotinamide + H(+)

Direction not assertedBalancedRhea 71899

guanine + NAD(+) = N(2)-(ADP-D-ribosyl)-guanine + nicotinamide + H(+)

Direction not assertedBalancedRhea 71903

GDP + NAD(+) = N(2)-(ADP-D-ribosyl)-GDP + nicotinamide + H(+)

Direction not assertedBalancedRhea 71907

cholate(out) + 2 Na(+)(out) = cholate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71911

tauronorcholate(out) + 2 Na(+)(out) = tauronorcholate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71915

succinate(out) + 3 Na(+)(out) = succinate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 71919

taurochenodeoxycholate(out) + 2 Na(+)(out) = taurochenodeoxycholate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71923

tauroursodeoxycholate(out) + 2 Na(+)(out) = tauroursodeoxycholate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71927

fumarate(out) + 3 Na(+)(out) = fumarate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 71931

glycocholate(out) + 2 Na(+)(out) = glycocholate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71935

2-oxoglutarate(out) + 3 Na(+)(out) = 2-oxoglutarate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 71939

(S)-malate(out) + 3 Na(+)(out) = (S)-malate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 71943

N-acetyl-L-aspartate(out) + 3 Na(+)(out) = N-acetyl-L-aspartate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 71947

sulfate(out) + 3 Na(+)(out) = sulfate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 71951

glutarate(out) + 3 Na(+)(out) = glutarate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 71955

oxaloacetate(out) + 3 Na(+)(out) = oxaloacetate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 71959

(R)-2-hydroxyglutarate(out) + 3 Na(+)(out) = (R)-2-hydroxyglutarate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 71963

(S)-2-hydroxyglutarate(out) + 3 Na(+)(out) = (S)-2-hydroxyglutarate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 71967

3-hydroxyglutarate(out) + 3 Na(+)(out) = 3-hydroxyglutarate(in) + 3 Na(+)(in)

Direction not assertedBalancedTransportRhea 71971

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