Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

14,801–14,850 of 18,558 reactions from Rhea

5-phosphomethyl-dUMP in DNA + putrescine = 5-N(alpha)-putrescinyl-dTMP in DNA + phosphate
Direction not assertedBalancedRhea 71575
CDP-L-ribitol(in) + CDP(out) = CDP-L-ribitol(out) + CDP(in)
Direction not assertedBalancedTransportRhea 71579
L-histidine(in) + Na(+)(in) = L-histidine(out) + Na(+)(out)
Right to leftBalancedTransportRhea 71583
(S)-malate(in) + 2-oxoglutarate(out) = (S)-malate(out) + 2-oxoglutarate(in)
Direction not assertedBalancedTransportRhea 71587
malonate(in) + 2-oxoglutarate(out) = malonate(out) + 2-oxoglutarate(in)
Direction not assertedBalancedTransportRhea 71591
succinate(in) + 2-oxoglutarate(out) = succinate(out) + 2-oxoglutarate(in)
Direction not assertedBalancedTransportRhea 71595

maleate(in) + 2-oxoglutarate(out) = maleate(out) + 2-oxoglutarate(in)

Direction not assertedBalancedTransportRhea 71599

oxaloacetate(in) + 2-oxoglutarate(out) = oxaloacetate(out) + 2-oxoglutarate(in)

Direction not assertedBalancedTransportRhea 71603

(S)-malate(in) + phosphate(out) = (S)-malate(out) + phosphate(in)

Direction not assertedBalancedTransportRhea 71607

malonate(out) + (S)-malate(in) = malonate(in) + (S)-malate(out)

Direction not assertedBalancedTransportRhea 71611

(S)-malate(in) + sulfate(out) = (S)-malate(out) + sulfate(in)

Direction not assertedBalancedTransportRhea 71615

2 thiosulfate(out) + (S)-malate(in) = 2 thiosulfate(in) + (S)-malate(out)

Direction not assertedBalancedTransportRhea 71619

malonate(out) + phosphate(in) = malonate(in) + phosphate(out)

Direction not assertedBalancedTransportRhea 71623

succinate(out) + phosphate(in) = succinate(in) + phosphate(out)

Direction not assertedBalancedTransportRhea 71627

sulfate(out) + phosphate(in) = sulfate(in) + phosphate(out)

Direction not assertedBalancedTransportRhea 71631

2 thiosulfate(out) + phosphate(in) = 2 thiosulfate(in) + phosphate(out)

Direction not assertedBalancedTransportRhea 71635

K(+)(in) + Na(+)(in) = K(+)(out) + Na(+)(out)

Direction not assertedBalancedTransportRhea 71639

guanosine + NAD(+) = N(2)-(ADP-D-ribosyl)-guanosine + nicotinamide + H(+)

Direction not assertedBalancedRhea 71643

a medium-chain (3S)-3-hydroxyacyl-CoA = a medium-chain (2E)-enoyl-CoA + H2O

Direction not assertedBalance undeterminableRhea 71647

a thymidine in DNA + NAD(+) = an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + nicotinamide + H(+)

Direction not assertedBalance undeterminableRhea 71651

an N-(ADP-alpha-D-ribosyl)-thymidine in DNA + H2O = a thymidine in DNA + ADP-D-ribose

Direction not assertedBalance undeterminableRhea 71655

a D-glucoside + 2 Fe(III)-[cytochrome c] = a 3-dehydro-D-glucoside + 2 Fe(II)-[cytochrome c] + 2 H(+)

Direction not assertedBalance undeterminableRhea 71659

a menaquinone + succinate + 2 H(+)(out) = a menaquinol + fumarate + 2 H(+)(in)

Direction not assertedBalance undeterminableTransportRhea 71663

malonate(out) + succinate(in) = malonate(in) + succinate(out)

Direction not assertedBalancedTransportRhea 71667

glycyl-L-glutamine(out) + H(+)(out) = glycyl-L-glutamine(in) + H(+)(in)

ReversibleBalancedTransportRhea 71671

glycyl-L-leucine(out) + H(+)(out) = glycyl-L-leucine(in) + H(+)(in)

Left to rightBalancedTransportRhea 71675

L-lysyl-glycine(out) + H(+)(out) = L-lysyl-glycine(in) + H(+)(in)

ReversibleBalancedTransportRhea 71679

L-aspartyl-glycine(out) + 2 H(+)(out) = L-aspartyl-glycine(in) + 2 H(+)(in)

Left to rightBalancedTransportRhea 71683

glycyl-L-aspartate(out) + 2 H(+)(out) = glycyl-L-aspartate(in) + 2 H(+)(in)

ReversibleBalancedTransportRhea 71687

glycyl-L-glutamate(out) + 2 H(+)(out) = glycyl-L-glutamate(in) + 2 H(+)(in)

Left to rightBalancedTransportRhea 71691

L-alanyl-L-aspartate(out) + 2 H(+)(out) = L-alanyl-L-aspartate(in) + 2 H(+)(in)

Left to rightBalancedTransportRhea 71695

L-phenylalanyl-L-leucine(out) + H(+)(out) = L-phenylalanyl-L-leucine(in) + H(+)(in)

Left to rightBalancedTransportRhea 71699

taurocholate(out) = taurocholate(in)

ReversibleBalancedTransportRhea 71703

L-phenylalanyl-L-phenylalanine(out) + H(+)(out) = L-phenylalanyl-L-phenylalanine(in) + H(+)(in)

Left to rightBalancedTransportRhea 71707

L-tyrosylglycine(out) + H(+)(out) = L-tyrosylglycine(in) + H(+)(in)

Left to rightBalancedTransportRhea 71711

L-leucyl-L-leucine(out) + H(+)(out) = L-leucyl-L-leucine(in) + H(+)(in)

Left to rightBalancedTransportRhea 71715

L-methionyl-L-phenylalanyl-L-methionine(out) + H(+)(out) = L-methionyl-L-phenylalanyl-L-methionine(in) + H(+)(in)

Left to rightBalancedTransportRhea 71719

L-alanyl-L-leucyl-L-alanine(out) + H(+)(out) = L-alanyl-L-leucyl-L-alanine(in) + H(+)(in)

Left to rightBalancedTransportRhea 71723

fumarate(in) + citrate(out) = fumarate(out) + citrate(in)

Direction not assertedBalancedTransportRhea 71727

tartrate(in) + citrate(out) = tartrate(out) + citrate(in)

Direction not assertedBalancedTransportRhea 71731

formyl-CoA + succinate = succinyl-CoA + formate

Direction not assertedBalancedRhea 71735

2-oxoadipate(in) + 2-oxoglutarate(out) = 2-oxoadipate(out) + 2-oxoglutarate(in)

Direction not assertedBalancedTransportRhea 71739

hexanedioate(in) + 2-oxoglutarate(out) = hexanedioate(out) + 2-oxoglutarate(in)

Direction not assertedBalancedTransportRhea 71743

L-2-aminoadipate(in) + 2-oxoglutarate(out) = L-2-aminoadipate(out) + 2-oxoglutarate(in)

Direction not assertedBalancedTransportRhea 71747

glutarate(in) + 2-oxoglutarate(out) = glutarate(out) + 2-oxoglutarate(in)

Direction not assertedBalancedTransportRhea 71751

2-oxoheptanedioate(in) + 2-oxoglutarate(out) = 2-oxoheptanedioate(out) + 2-oxoglutarate(in)

Direction not assertedBalancedTransportRhea 71755

heptanedioate(in) + 2-oxoglutarate(out) = heptanedioate(out) + 2-oxoglutarate(in)

Direction not assertedBalancedTransportRhea 71759

citrate(in) + 2-oxoglutarate(out) = citrate(out) + 2-oxoglutarate(in)

Direction not assertedBalancedTransportRhea 71763

2 Fe(2+) + NADP(+) + H(+) = 2 Fe(3+) + NADPH

Right to leftBalancedRhea 71767

2 Cu(+) + NADP(+) + H(+) = 2 Cu(2+) + NADPH

Right to leftBalancedRhea 71771

Page 297 of 372