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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

14,701–14,750 of 18,558 reactions from Rhea

glycine betaine(out) + 2 chloride(out) + 3 Na(+)(out) = glycine betaine(in) + 2 chloride(in) + 3 Na(+)(in)
Left to rightBalancedTransportRhea 71175
L-histidine(out) + L-tryptophan(in) = L-histidine(in) + L-tryptophan(out)
Direction not assertedBalancedTransportRhea 71179
L-kynurenine(out) + L-tryptophan(in) = L-kynurenine(in) + L-tryptophan(out)
Direction not assertedBalancedTransportRhea 71183
3-hydroxy-L-kynurenine(out) + L-tryptophan(in) = 3-hydroxy-L-kynurenine(in) + L-tryptophan(out)
Direction not assertedBalancedTransportRhea 71187
an L-alpha-amino acid(in) + L-kynurenine(out) = an L-alpha-amino acid(out) + L-kynurenine(in)
Direction not assertedBalance undeterminableTransportRhea 71191
Zn(2+)(out) + H(+)(out) = Zn(2+)(in) + H(+)(in)
Left to rightBalancedTransportRhea

71195

L-ornithine(in) = L-ornithine(out)

Direction not assertedBalancedTransportRhea 71199

L-homoarginine(in) = L-homoarginine(out)

Direction not assertedBalancedTransportRhea 71203

iodide(out) + 2 Na(+)(out) = iodide(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71207

chlorate(out) + 2 Na(+)(out) = chlorate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71211

thiocyanate(out) + 2 Na(+)(out) = thiocyanate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71215

nitrate(out) + 2 Na(+)(out) = nitrate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71219

taurine(out) + chloride(out) + 2 Na(+)(out) = taurine(in) + chloride(in) + 2 Na(+)(in)

Left to rightBalancedTransportRhea 71223

selenocyanate(out) + 2 Na(+)(out) = selenocyanate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71227

2 Fe(3+)-[Dph3] + NADH = 2 Fe(2+)-[Dph3] + NAD(+) + H(+)

Direction not assertedBalance undeterminableRhea 71231

[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]

Direction not assertedBalance undeterminableRhea 71235

2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)

Direction not assertedBalance undeterminableRhea 71239

hypotaurine(out) + chloride(out) + 2 Na(+)(out) = hypotaurine(in) + chloride(in) + 2 Na(+)(in)

Left to rightBalancedTransportRhea 71243

beta-alanine(out) + chloride(out) + 2 Na(+)(out) = beta-alanine(in) + chloride(in) + 2 Na(+)(in)

Left to rightBalancedTransportRhea 71247

L-xylopyranose = L-xylulose

Direction not assertedBalancedRhea 71251

3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in)

Left to rightBalancedTransportRhea 71255

2 Na(+)(out) + phosphate(out) = 2 Na(+)(in) + phosphate(in)

Left to rightBalancedTransportRhea 71259

L-proline(out) + chloride(out) + 2 Na(+)(out) = L-proline(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71263

L-pipecolate(out) + chloride(out) + 2 Na(+)(out) = L-pipecolate(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71267

thiamine(out) + H(+)(in) = thiamine(in) + H(+)(out)

Direction not assertedBalancedTransportRhea 71271

taurolithocholate 3-sulfate(out) + 2 Na(+)(out) = taurolithocholate 3-sulfate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71275

L-leucine(out) + chloride(out) + 2 Na(+)(out) = L-leucine(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71279

L-glutamine(out) + chloride(out) + 2 Na(+)(out) = L-glutamine(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71283

L-arginine(out) + chloride(out) + 2 Na(+)(out) = L-arginine(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71287

(R)-carnitine(out) + chloride(out) + 2 Na(+)(out) = (R)-carnitine(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71291

O-propanoyl-(R)-carnitine(out) + chloride(out) + 2 Na(+)(out) = O-propanoyl-(R)-carnitine(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71295

L-isoleucine(out) + chloride(out) + 2 Na(+)(out) = L-isoleucine(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71299

L-methionine(out) + chloride(out) + 2 Na(+)(out) = L-methionine(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71303

L-valine(out) + chloride(out) + 2 Na(+)(out) = L-valine(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71307

L-alanine(out) + chloride(out) + 2 Na(+)(out) = L-alanine(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71311

L-serine(out) + chloride(out) + 2 Na(+)(out) = L-serine(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71315

L-cysteine(out) + chloride(out) + 2 Na(+)(out) = L-cysteine(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71319

L-asparagine(out) + chloride(out) + 2 Na(+)(out) = L-asparagine(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71323

L-threonine(out) + chloride(out) + 2 Na(+)(out) = L-threonine(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71327

L-phenylalanine(out) + chloride(out) + 2 Na(+)(out) = L-phenylalanine(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71331

L-tryptophan(out) + chloride(out) + 2 Na(+)(out) = L-tryptophan(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71335

L-tyrosine(out) + chloride(out) + 2 Na(+)(out) = L-tyrosine(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71339

L-histidine(out) + chloride(out) + 2 Na(+)(out) = L-histidine(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71343

L-lysine(out) + chloride(out) + 2 Na(+)(out) = L-lysine(in) + chloride(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71347

androsterone 3alpha-sulfate(out) + 2 Na(+)(out) = androsterone 3alpha-sulfate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71351

5alpha-dihydrotestosterone sulfate(out) + 2 Na(+)(out) = 5alpha-dihydrotestosterone sulfate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71355

17beta-estradiol 17-sulfate(out) + 2 Na(+)(out) = 17beta-estradiol 17-sulfate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71359

17alpha-hydroxypregnenolone 3-sulfate(out) + 2 Na(+)(out) = 17alpha-hydroxypregnenolone 3-sulfate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71363

epiandrosterone 3-sulfate(out) + 2 Na(+)(out) = epiandrosterone 3-sulfate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71367

epitestosterone 17-sulfate(out) + 2 Na(+)(out) = epitestosterone 17-sulfate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71371

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