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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Chemistry

Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

14,651–14,700 of 18,558 reactions from Rhea

3-sulfino-L-alanine(out) + L-aspartate(in) = 3-sulfino-L-alanine(in) + L-aspartate(out)
Direction not assertedBalancedTransportRhea 70975
4-aminobutanoate(out) + n H(+)(in) = 4-aminobutanoate(in) + n H(+)(out)
Direction not assertedBalance undeterminableTransportRhea 70979
glycine(out) + n H(+)(in) = glycine(in) + n H(+)(out)
Direction not assertedBalance undeterminableTransportRhea 70983
beta-alanine(out) + n H(+)(in) = beta-alanine(in) + n H(+)(out)
Direction not assertedBalance undeterminableTransportRhea 70987
L-mannopyranose(in) + H(+)(in) = L-mannopyranose(out) + H(+)(out)
Direction not assertedBalancedTransportRhea 70991
L-cystine(out) + L-glutamate(in) = L-cystine(in) + L-glutamate(out)
Direction not assertedBalancedTransportRhea

70995

(S)-nicotine + reduced [NADPH--hemoprotein reductase] + O2 = (S)-nornicotine + formaldehyde + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 70999

L-histidine(in) + L-phenylalanine(out) = L-histidine(out) + L-phenylalanine(in)

Direction not assertedBalancedTransportRhea 71003

L-tryptophan(in) + L-phenylalanine(out) = L-tryptophan(out) + L-phenylalanine(in)

Direction not assertedBalancedTransportRhea 71007

L-isoleucine(in) + L-phenylalanine(out) = L-isoleucine(out) + L-phenylalanine(in)

Direction not assertedBalancedTransportRhea 71011

N-methylputrescine + O2 + H2O = 4-methylaminobutanal + H2O2 + NH4(+)

Direction not assertedBalancedRhea 71015

L-valine(in) + L-phenylalanine(out) = L-valine(out) + L-phenylalanine(in)

Direction not assertedBalancedTransportRhea 71019

L-leucine(in) + L-phenylalanine(out) = L-leucine(out) + L-phenylalanine(in)

Direction not assertedBalancedTransportRhea 71023

L-phenylalanine(out) + L-glutamine(in) = L-phenylalanine(in) + L-glutamine(out)

Direction not assertedBalancedTransportRhea 71027

L-cysteine(in) + L-phenylalanine(out) = L-cysteine(out) + L-phenylalanine(in)

Direction not assertedBalancedTransportRhea 71031

L-phenylalanine(out) + L-serine(in) = L-phenylalanine(in) + L-serine(out)

Direction not assertedBalancedTransportRhea 71035

L-phenylalanine(out) + L-methionine(in) = L-phenylalanine(in) + L-methionine(out)

Direction not assertedBalancedTransportRhea 71039

L-phenylalanine(out) + L-alanine(in) = L-phenylalanine(in) + L-alanine(out)

Direction not assertedBalancedTransportRhea 71043

L-phenylalanine(out) + glycine(in) = L-phenylalanine(in) + glycine(out)

Direction not assertedBalancedTransportRhea 71047

L-leucine(out) + L-methionine(in) = L-leucine(in) + L-methionine(out)

Direction not assertedBalancedTransportRhea 71051

L-cysteine(out) + L-methionine(in) = L-cysteine(in) + L-methionine(out)

Direction not assertedBalancedTransportRhea 71055

L-leucine(out) + L-arginine(in) = L-leucine(in) + L-arginine(out)

Left to rightBalancedTransportRhea 71059

L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)

Left to rightBalancedTransportRhea 71063

L-arginine(in) + L-phenylalanine(out) = L-arginine(out) + L-phenylalanine(in)

Left to rightBalancedTransportRhea 71067

L-cysteine(out) + L-arginine(in) = L-cysteine(in) + L-arginine(out)

Left to rightBalancedTransportRhea 71071

L-cystine(out) + L-arginine(in) = L-cystine(in) + L-arginine(out)

Left to rightBalancedTransportRhea 71075

cordypyrone A + reduced [NADPH--hemoprotein reductase] + O2 = cordypyrone B + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 71079

estrone 3-sulfate(out) + 2 Na(+)(out) = estrone 3-sulfate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71083

17beta-estradiol 3-sulfate(out) + 2 Na(+)(out) = 17beta-estradiol 3-sulfate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71087

dehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) = dehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71091

pregnenolone sulfate(out) + 2 Na(+)(out) = pregnenolone sulfate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71095

androst-5-ene-diol 3-sulfate(out) + 2 Na(+)(out) = androst-5-ene-diol 3-sulfate(in) + 2 Na(+)(in)

Direction not assertedBalancedTransportRhea 71099

S-methylmercury-L-cysteine(out) + L-methionine(in) = S-methylmercury-L-cysteine(in) + L-methionine(out)

Direction not assertedBalancedTransportRhea 71103

S-methylmercury-L-cysteine(in) + L-leucine(out) = S-methylmercury-L-cysteine(out) + L-leucine(in)

Direction not assertedBalancedTransportRhea 71107

S-methylmercury-L-cysteine(in) + L-phenylalanine(out) = S-methylmercury-L-cysteine(out) + L-phenylalanine(in)

Direction not assertedBalancedTransportRhea 71111

hispidin + NADH + O2 + H(+) = 3-hydroxyhispidin + NAD(+) + H2O

Direction not assertedBalancedRhea 71115

hispidin + NADPH + O2 + H(+) = 3-hydroxyhispidin + NADP(+) + H2O

Direction not assertedBalancedRhea 71119

(E)-caffeate + 2 malonyl-CoA + ATP + H(+) = hispidin + AMP + 2 CO2 + diphosphate + 2 CoA

Direction not assertedBalancedRhea 71123

L-glutamine(out) + Na(+)(out) + H(+)(in) = L-glutamine(in) + Na(+)(in) + H(+)(out)

ReversibleBalancedTransportRhea 71127

L-asparagine(out) + Na(+)(out) + H(+)(in) = L-asparagine(in) + Na(+)(in) + H(+)(out)

ReversibleBalancedTransportRhea 71131

L-histidine(out) + Na(+)(out) + H(+)(in) = L-histidine(in) + Na(+)(in) + H(+)(out)

ReversibleBalancedTransportRhea 71135

10 malonyl-CoA + acetyl-CoA + 3 AH2 + 8 NADPH + 18 H(+) = cordypyrone A + 3 A + 10 CO2 + 8 NADP(+) + 11 CoA + 8 H2O

Direction not assertedBalancedRhea 71139

3-hydroxyhispidin + O2 = (E)-caffeoylpyruvate + hnu + CO2

Direction not assertedBalance undeterminableRhea 71143

3-hydroxyhispidin + O2 = 4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one

Direction not assertedBalancedRhea 71147

4-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-1,7-dihydroxy-2,3,5-trioxabicyclo[2.2.2]oct-7-en-6-one = (E)-caffeoylpyruvate + hnu + CO2

Direction not assertedBalance undeterminableRhea 71151

(E)-caffeoylpyruvate + H2O = (E)-caffeate + pyruvate + H(+)

Direction not assertedBalancedRhea 71155

L-serine(out) + Na(+)(out) + H(+)(in) = L-serine(in) + Na(+)(in) + H(+)(out)

ReversibleBalancedTransportRhea 71159

L-alanine(out) + Na(+)(out) + H(+)(in) = L-alanine(in) + Na(+)(in) + H(+)(out)

ReversibleBalancedTransportRhea 71163

glycine(out) + Na(+)(out) + H(+)(in) = glycine(in) + Na(+)(in) + H(+)(out)

ReversibleBalancedTransportRhea 71167

L-cysteine(out) + Na(+)(out) + H(+)(in) = L-cysteine(in) + Na(+)(in) + H(+)(out)

ReversibleBalancedTransportRhea 71171

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