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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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Reference

Evidence

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Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

14,451–14,500 of 18,558 reactions from Rhea

pemetrexed(in) + H(+)(in) = pemetrexed(out) + H(+)(out)
Direction not assertedBalancedTransportRhea 70171
beta-D-glucosyl-(1->4)-D-galactose + phosphate = D-galactose + alpha-D-glucose 1-phosphate
Direction not assertedBalancedRhea 70175
2 D-maltotetraose = alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose
Direction not assertedBalancedRhea 70179
2 alpha-isomaltosyl-(1->4)-D-maltotriose = alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose + D-maltotriose
Direction not assertedBalancedRhea 70183
alpha-isomaltosyl-(1->3)-alpha-isomaltosyl-(1->4)-D-maltotriose = cyclobis-(1->3)-alpha-D-isomaltosyl + D-maltotriose
Direction not assertedBalancedRhea 70187
NAD(+) + ATP = 3'-NADP(+) + ADP + H(+)
Direction not assertedBalancedRhea 70191

deamido-NAD(+) + ATP = nicotinate-adenine dinucleotide 3'-phosphate + ADP + H(+)

Direction not assertedBalancedRhea 70195

dopaminechrome = 5,6-dihydroxyindole

Direction not assertedBalancedRhea 70199

N-methyldopaminechrome = 5,6-dihydroxyindole-N-methyl

Direction not assertedBalancedRhea 70203

sphinga-4E,14Z-dienine-1-phosphate(in) = sphinga-4E,14Z-dienine-1-phosphate(out)

Direction not assertedBalancedTransportRhea 70207

GDP-D-glycero-alpha-D-manno-heptose + 2-oxoglutarate = GDP-D-glycero-4-keto-alpha-D-lyxo-heptose + (S)-2-hydroxyglutarate

Direction not assertedBalancedRhea 70211

cortisol + NADPH + H(+) = 20beta-dihydrocortisol + NADP(+)

Left to rightBalancedRhea 70215

corticosterone + NADPH + H(+) = 20beta-dihydrocorticosterone + NADP(+)

Left to rightBalancedRhea 70219

(2S)-2-aminobutanoate + 2-oxoglutarate = 2-oxobutanoate + L-glutamate

Right to leftBalancedRhea 70223

(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA = (E)-2-benzylidenesuccinyl-CoA + H2O

Direction not assertedBalancedRhea 70227

(2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA + NAD(+) = (S)-2-benzoylsuccinyl-CoA + NADH + H(+)

Direction not assertedBalancedRhea 70231

a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-galactoside + an N-acylsphing-4-enine

ReversibleBalance undeterminableRhea 70235

a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + an N-acylsphing-4-enine

ReversibleBalance undeterminableRhea 70239

UDP-alpha-D-xylose + an N-acylsphing-4-enine = a beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine + UDP + H(+)

Left to rightBalance undeterminableRhea 70243

N-(9Z-octadecenoyl)-sphing-4-enine + UDP-alpha-D-xylose = beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + UDP + H(+)

Left to rightBalancedRhea 70247

beta-D-xylosyl-(1<->1')-N-(9Z-octadecenoyl)-sphing-4-enine + cholesterol = cholesteryl 3-beta-D-xyloside + N-(9Z-octadecenoyl)-sphing-4-enine

Left to rightBalancedRhea 70251

1-(beta-D-galactosyl)-N-dodecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-galactoside + N-dodecanoylsphing-4-enine

ReversibleBalancedRhea 70255

AMP(out) + phosphate(in) = AMP(in) + phosphate(out)

Direction not assertedBalancedTransportRhea 70259

1D-myo-inositol 1,3,4-trisphosphate + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = 1D-myo-inositol 3,4,5,6-tetrakisphosphate + 1D-myo-inositol 1,3,4,6-tetrakisphosphate

ReversibleBalancedRhea 70263

hydrogencarbonate(in) + Na(+)(in) = hydrogencarbonate(out) + Na(+)(out)

Direction not assertedBalancedTransportRhea 70267

1D-myo-inositol 1,3,4-trisphosphate + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = 1D-myo-inositol 3,4,5,6-tetrakisphosphate + 1D-myo-inositol 1,3,4,5-tetrakisphosphate

ReversibleBalancedRhea 70271

raffinose + H2O = sucrose + D-galactose

Direction not assertedBalancedRhea 70275

stachyose + H2O = raffinose + D-galactose

Direction not assertedBalancedRhea 70279

N-acetylputrescine + O2 + H2O = 4-acetamidobutanal + H2O2 + NH4(+)

Left to rightBalancedRhea 70283

1D-myo-inositol 3,4,6-trisphosphate + ATP = 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ADP + H(+)

ReversibleBalancedRhea 70287

3-(2-aminophenyl)-3-oxopropanal = quinolin-4-ol + H2O

Direction not assertedBalancedRhea 70291

3-sulfino-L-alanine + 2-oxoglutarate = 3-sulfinopyruvate + L-glutamate

Right to leftBalancedRhea 70295

L-dehydroascorbate + H2O = 2,3-dioxo-L-gulonate

Direction not assertedBalancedRhea 70299

beta-D-glucosyl-N-octanoylsphing-4E-enine + cholesterol = N-octanoylsphing-4-enine + cholesteryl 3-beta-D-glucoside

ReversibleBalancedRhea 70303

beta-D-glucosyl-N-dodecanoylsphing-4-enine + cholesterol = N-dodecanoylsphing-4-enine + cholesteryl 3-beta-D-glucoside

ReversibleBalancedRhea 70307

beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-octadecanoylsphing-4-enine

ReversibleBalancedRhea 70311

beta-D-glucosyl-(1<->1')-N-(15Z-tetracosenoyl)-sphing-4-enine + cholesterol = N-(15Z-tetracosenoyl)-sphing-4-enine + cholesteryl 3-beta-D-glucoside

ReversibleBalancedRhea 70315

1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 3,4-bisphosphate + phosphate

Left to rightBalancedRhea 70319

2,3-dioxo-L-gulonate = 2-carboxy-L-lyxonolactone

Direction not assertedBalancedRhea 70323

(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NAD(+) = 4-methylsulfanyl-2-oxobutanoate + NADH + H(+)

Direction not assertedBalancedRhea 70327

3-hydroxyphenylacetyl-CoA + H2O = 3-hydroxyphenylacetate + CoA + H(+)

Direction not assertedBalancedRhea 70331

2-carboxy-L-lyxonolactone + H2O = 2-carboxy-L-lyxonate + H(+)

Direction not assertedBalancedRhea 70335

alpha-D-Gal-(1->6)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O = beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose

Direction not assertedBalancedRhea 70339

L-tyrosine + chloride + NADP(+) = 3-chloro-L-tyrosine + NADPH

Right to leftBalancedRhea 70343

bromide + L-tyrosine + NADP(+) = 3-bromo-L-tyrosine + NADPH

Right to leftBalancedRhea 70347

beta-D-Man-(1->4)-[alpha-D-Gal-(1->6)]-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + H2O = beta-D-Man-(1->4)-beta-D-Man-(1->4)-beta-D-Man-(1->4)-D-Man + D-galactose

Direction not assertedBalancedRhea 70351

1-carboxybiuret + H(+) = biuret + CO2

Direction not assertedBalancedRhea 70355

3-oxosphinganine + a fatty acyl-CoA = N-acyl-3-oxosphinganine + CoA + H(+)

Direction not assertedBalance undeterminableRhea 70359

cyanurate + H2O = 1-carboxybiuret + H(+)

Direction not assertedBalancedRhea 70363

3-oxosphinganine + octanoyl-CoA = N-octanoyl-3-oxosphinganine + CoA + H(+)

Direction not assertedBalancedRhea 70367

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