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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Interactions
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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

14,251–14,300 of 18,558 reactions from Rhea

6-diazo-5-oxo-L-norleucine + acetyl-CoA = N(alpha)-acetyl-6-diazo-5-oxo-L-norleucine + CoA + H(+)
Direction not assertedBalancedRhea 69364
11beta,17beta-dihydroxyandrost-4-ene-3-one + NAD(+) = 17beta-hydroxyandrost-4-ene-3,11-dione + NADH + H(+)
Left to rightBalancedRhea 69368
2-hydroxyhexanoate + O2 = 2-oxohexanoate + H2O2
Direction not assertedBalancedRhea 69372
2-hydroxydodecanoate + O2 = 2-oxododecanoate + H2O2
Direction not assertedBalancedRhea 69376
2-hydroxy-4-methylpentanoate + O2 = 4-methyl-2-oxopentanoate + H2O2
Direction not assertedBalancedRhea 69380
Co(I)-[quaternary-amine-specific corrinoid protein] + (R)-carnitine + H(+) = (3R)-4-(dimethylamino)-3-hydroxybutanoate + methyl-Co(III)-[quaternary-amine-specific corrinoid protein]
Direction not assertedBalance undeterminableRhea 69384

(S)-2-ureidoglycine + carbamoyl phosphate = allantoate + phosphate + H(+)

Direction not assertedBalancedRhea 69388

an alpha-Kdo-(2->6)-lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)

Direction not assertedBalance undeterminableRhea 69392

an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + a fatty acyl-[ACP] = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA + holo-[ACP]

Direction not assertedBalance undeterminableRhea 69396

an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-(acyl)-lipid IVA + a fatty acyl-[ACP] = an alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid A + holo-[ACP]

Direction not assertedBalance undeterminableRhea 69400

uracil(in) = uracil(out)

ReversibleBalancedTransportRhea 69404

11beta-hydroxyandrost-4-ene-3,17-dione + NAD(+) = androst-4-ene-3,11,17-trione + NADH + H(+)

Left to rightBalancedRhea 69408

tert-butyl hydroperoxide + 2 glutathione = tert-butanol + glutathione disulfide + H2O

Left to rightBalancedRhea 69412

thiocyanate + H2O2 + H(+) = hypothiocyanous acid + H2O

Left to rightBalancedRhea 69416

iodide + H2O2 = hypoiodite + H2O

Left to rightBalancedRhea 69420

2-hydroxyisobutanoyl-CoA = formyl-CoA + acetone

Direction not assertedBalancedRhea 69424

arsenite + 3 glutathione + H(+) = arsenic triglutathione + 3 H2O

Direction not assertedBalancedRhea 69428

arsenic triglutathione + 3 [thioredoxin]-dithiol + 3 S-adenosyl-L-methionine = trimethylarsine + 3 [thioredoxin]-disulfide + 3 glutathione + 3 S-adenosyl-L-homocysteine + 3 H(+)

Direction not assertedBalance undeterminableRhea 69432

7-oxopregnenolone + NADPH + H(+) = 7beta-hydroxypregnenolone + NADP(+)

Left to rightBalancedRhea 69436

3beta,7alpha-dihydroxyandrost-5-en-17-one + NADP(+) = 3beta-hydroxy-5-androstene-7,17-dione + NADPH + H(+)

Left to rightBalancedRhea 69440

(2E,6E)-farnesyl diphosphate = alpha-cadinene + diphosphate

Direction not assertedBalancedRhea 69444

(2E,6E)-farnesyl diphosphate + H2O = (-)-delta-cadinol + diphosphate

Direction not assertedBalancedRhea 69448

3beta-hydroxy-5-androstene-7,17-dione + NADPH + H(+) = 3beta,7beta-dihydroxyandrost-5-en-17-one + NADP(+)

Left to rightBalancedRhea 69452

3beta-hydroxy-5alpha-androstane-7,17-dione + NADPH + H(+) = 3beta,7beta-dihydroxy-5alpha-androstan-17-one + NADP(+)

Left to rightBalancedRhea 69456

arsenic triglutathione + [thioredoxin]-dithiol + S-adenosyl-L-methionine + 2 H2O = methylarsonous acid + [thioredoxin]-disulfide + 3 glutathione + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 69460

arsenic triglutathione + 2 [thioredoxin]-dithiol + 2 S-adenosyl-L-methionine + H2O = dimethylarsinous acid + 2 [thioredoxin]-disulfide + 3 glutathione + 2 S-adenosyl-L-homocysteine + 2 H(+)

Direction not assertedBalance undeterminableRhea 69464

UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate = UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose + L-glutamate

Direction not assertedBalancedRhea 69468

UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose + a (3R)-hydroxyacyl-[ACP] = a UDP-2-acetamido-3-{[(3R)-3-hydroxyacyl]amino}-2,3-dideoxy-alpha-D-glucopyranose + holo-[ACP] + H(+)

Direction not assertedBalance undeterminableRhea 69472

L-lysine + acetyl-CoA = N(6)-acetyl-L-lysine + CoA + H(+)

Direction not assertedBalancedRhea 69476

an N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-beta-D-GlcNAc-R + UDP + H(+)

Direction not assertedBalance undeterminableRhea 69480

dodecan-1-ol + O2 = dodecanal + H2O2

Direction not assertedBalancedRhea 69484

tetradecan-1-ol + O2 = tetradecanal + H2O2

Direction not assertedBalancedRhea 69488

octan-1-ol + O2 = octanal + H2O2

Direction not assertedBalancedRhea 69492

decan-1-ol + O2 = decanal + H2O2

Direction not assertedBalancedRhea 69496

L-arginyl-[protein] + NAD(+) = ADP-riboxanated L-argininyl-[protein] + nicotinamide + NH4(+) + H(+)

Direction not assertedBalance undeterminableRhea 69500

N-acetyl-D-glucosamine + O2 = N-acetyl-D-glucosamino-1,5-lactone + H2O2

Direction not assertedBalancedRhea 69504

N-acetyl-D-glucosamino-1,5-lactone + H2O = N-acetyl-D-glucosaminate + H(+)

Direction not assertedBalancedRhea 69508

N-acetyl-D-galactosamine + O2 + H2O = N-acetyl-D-galactosaminate + H2O2 + H(+)

Direction not assertedBalancedRhea 69512

N-acetyl-D-galactosamine + O2 = N-acetyl-D-galactosamino-1,5-lactone + H2O2

Direction not assertedBalancedRhea 69516

N-acetyl-D-galactosamino-1,5-lactone + H2O = N-acetyl-D-galactosaminate + H(+)

Direction not assertedBalancedRhea 69520

D-sorbitol + O2 = D-glucose + H2O2

Direction not assertedBalancedRhea 69524

chorismate + 2 L-glutamine + H2O = 4-amino-4-deoxychorismate + 2 L-glutamate + NH4(+)

Direction not assertedBalancedRhea 69528

(2S)-2-amino-4-deoxychorismate = 4-amino-4-deoxychorismate

Direction not assertedBalancedRhea 69532

alpha-D-tagatopyranose 1-phosphate + ATP = D-tagatofuranose 1,6-bisphosphate + ADP + H(+)

Direction not assertedBalancedRhea 69536

streptomycin + GTP = 6-O-guanylylstreptomycin + diphosphate

Direction not assertedBalancedRhea 69540

streptidine + ATP = 6-O-adenylylstreptidine + diphosphate

Direction not assertedBalancedRhea 69544

O-phospho-L-serine + H(+) = phosphoethanolamine + CO2

Direction not assertedBalancedRhea 69548

dihydroxyacetone phosphate + L-glutamate = (S)-serinol phosphate + 2-oxoglutarate

Direction not assertedBalancedRhea 69552

D-glucose(out) + H(+)(out) = D-glucose(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 69556

D-mannose(out) + H(+)(out) = D-mannose(in) + H(+)(in)

Direction not assertedBalancedTransportRhea 69560

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