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Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Chemistry

Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

14,101–14,150 of 18,558 reactions from Rhea

(R)-3-phenyllactate + 3 (R)-lactate + 4 L-leucine + 4 S-adenosyl-L-methionine + 8 ATP = PF1022D + 8 AMP + 4 S-adenosyl-L-homocysteine + 8 diphosphate + 8 H(+)
Direction not assertedBalancedRhea 68764
4 (R)-lactate + 4 L-leucine + 4 S-adenosyl-L-methionine + 8 ATP = PF1022F + 8 AMP + 4 S-adenosyl-L-homocysteine + 8 diphosphate + 8 H(+)
Direction not assertedBalancedRhea 68768
(2Z,6Z)-farnesyl diphosphate = germacrene C + diphosphate
Direction not assertedBalancedRhea 68772
(2Z,6Z)-farnesyl diphosphate = germacrene A + diphosphate
Direction not assertedBalancedRhea 68776
(2Z,6Z)-farnesyl diphosphate = alpha-humulene + diphosphate
Direction not assertedBalancedRhea 68780
(2Z,6Z)-farnesyl diphosphate = gamma-curcumene + diphosphate
Direction not assertedBalancedRhea 68784

(2Z,6Z)-farnesyl diphosphate = (Z)-gamma-bisabolene + diphosphate

Direction not assertedBalancedRhea 68788

alpha-NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+)

Direction not assertedBalancedRhea 68792

D-maltose + H2O = alpha-D-glucose + D-glucose

Left to rightBalancedRhea 68796

nigerose + H2O = alpha-D-glucose + D-glucose

Left to rightBalancedRhea 68800

kojibiose + H2O = alpha-D-glucose + D-glucose

Left to rightBalancedRhea 68804

6-O-alpha-D-glucopyranosyl-D-fructose + H2O = alpha-D-glucose + D-fructose

Left to rightBalancedRhea 68808

(2Z,6E)-farnesyl diphosphate = beta-bisabolene + diphosphate

Direction not assertedBalancedRhea 68812

(2Z,6E)-farnesyl diphosphate = (E)-alpha-bisabolene + diphosphate

Direction not assertedBalancedRhea 68816

(2Z,6E)-farnesyl diphosphate + H2O = (6E)-nerolidol + diphosphate

Direction not assertedBalancedRhea 68820

(2E)-geranyl diphosphate = (Z)-beta-ocimene + diphosphate

Direction not assertedBalancedRhea 68824

borneol + NAD(+) = camphor + NADH + H(+)

Direction not assertedBalancedRhea 68828

(2Z,6Z)-farnesyl diphosphate + H2O = (6Z)-nerolidol + diphosphate

Direction not assertedBalancedRhea 68832

(2Z,6E)-farnesyl diphosphate = (6R,7S)-himachala-9,11-diene + diphosphate

Direction not assertedBalancedRhea 68836

(2Z,6E)-farnesyl diphosphate = (6R,7S)-2,2,6-trimethyl-10-methylenebicyclo[5.4.0]undec-1(11)-ene + diphosphate

Direction not assertedBalancedRhea 68840

(2Z,6E)-farnesyl diphosphate = (Z)-alpha-bisabolene + diphosphate

Direction not assertedBalancedRhea 68844

(2Z,6E)-farnesyl diphosphate = gamma-cadinene + diphosphate

Direction not assertedBalancedRhea 68848

(2E,6E)-farnesyl diphosphate + H2O = (1S,6S,7R)-sesquipiperitol + diphosphate

Direction not assertedBalancedRhea 68852

(2Z,6E)-farnesyl diphosphate = (E)-beta-farnesene + diphosphate

Direction not assertedBalancedRhea 68856

7-oxo-25-hydroxycholesterol + NADPH + H(+) = 7beta-25-dihydroxycholesterol + NADP(+)

Direction not assertedBalancedRhea 68860

isomaltose + H2O = alpha-D-glucose + D-glucose

Left to rightBalancedRhea 68864

benzoate + ATP + NADPH + H(+) = benzaldehyde + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68868

(E)-cinnamate + ATP + NADPH + H(+) = (E)-cinnamaldehyde + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68872

piperonylate + ATP + NADPH + H(+) = piperonal + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68876

salicylate + ATP + NADPH + H(+) = salicylaldehyde + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68880

3-hydroxybenzoate + ATP + NADPH + H(+) = 3-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68884

2-methoxybenzoate + ATP + NADPH + H(+) = 2-methoxybenzaldehyde + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68888

3-methoxybenzoate + ATP + NADPH + H(+) = 3-methoxybenzaldehyde + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68892

4-hydroxybenzoate + ATP + NADPH + H(+) = 4-hydroxybenzaldehyde + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68896

4-methoxybenzoate + ATP + NADPH + H(+) = 4-methoxybenzaldehyde + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68900

3-phenylpropanoate + ATP + NADPH + H(+) = 3-phenylpropanal + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68904

picolinate + ATP + NADPH + H(+) = picolinal + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68908

propanoate + ATP + NADPH + H(+) = propanal + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68912

butanoate + ATP + NADPH + H(+) = butanal + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68916

pentanoate + ATP + NADPH + H(+) = pentanal + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68920

hexanoate + ATP + NADPH + H(+) = hexanal + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68924

heptanoate + ATP + NADPH + H(+) = heptanal + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68928

octanoate + ATP + NADPH + H(+) = octanal + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68932

nonanoate + ATP + NADPH + H(+) = nonanal + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 68936

tellurite(in) + Na(+)(in) = tellurite(out) + Na(+)(out)

Direction not assertedBalancedTransportRhea 68940

esculetin + S-adenosyl-L-methionine = isoscopoletin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 68944

esculetin + S-adenosyl-L-methionine = scopoletin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 68948

isoscopoletin + S-adenosyl-L-methionine = scoparone + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 68952

scopoletin + S-adenosyl-L-methionine = scoparone + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 68956

7,8-dihydroxycoumarin + S-adenosyl-L-methionine = 7-hydroxy-8-methoxycoumarin + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 68960

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