Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

13,901–13,950 of 18,558 reactions from Rhea

4-methylamino-L-phenylalanine + S-adenosyl-L-methionine = 4-dimethylamino-L-phenylalanine + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalancedRhea 67964
presqualene diphosphate + H2O = presqualene phosphate + phosphate + H(+)
Left to rightBalancedRhea 67968
ecdysone + ATP = ecdysone 22-phosphate + ADP + H(+)
Direction not assertedBalancedRhea 67972
all-trans-neurosporene = beta-zeacarotene
Direction not assertedBalancedRhea 67976
beta-zeacarotene = 7,8-dihydro-beta-carotene
Direction not assertedBalancedRhea 67980
N-acetyl-L-leucine = N-acetyl-D-leucine
Direction not assertedBalancedRhea 67984
N-acetyl-L-glutamine = N-acetyl-D-glutamine

? Direction not asserted

Balanced

Rhea 67988

trichloroethene + AH2 = (Z)-1,2-dichloroethene + chloride + A + H(+)

Direction not assertedBalancedRhea 67992

(Z)-1,2-dichloroethene + AH2 = chloroethene + chloride + A + H(+)

Direction not assertedBalancedRhea 67996

1,1-dichloroethene + AH2 = chloroethene + chloride + A + H(+)

Direction not assertedBalancedRhea 68000

chloroethene + AH2 = ethene + chloride + A + H(+)

Direction not assertedBalancedRhea 68004

(2E,6E,10E)-geranylgeranyl diphosphate + H2O = (2E,6E,10E)-geranylgeranyl phosphate + phosphate + H(+)

Left to rightBalancedRhea 68008

hypoxanthine + O2 + H2O = xanthine + H2O2

Direction not assertedBalancedRhea 68012

(2E,6E,10E)-geranylgeranyl phosphate + H2O = (2E,6E,10E)-geranylgeraniol + phosphate

Left to rightBalancedRhea 68016

(2E)-geranyl phosphate + H2O = (2E)-geraniol + phosphate

Left to rightBalancedRhea 68020

presqualene phosphate + H2O = presqualene alcohol + phosphate

Left to rightBalancedRhea 68024

6,8-dihydroxypurine + O2 + H2O = urate + H2O2

Direction not assertedBalancedRhea 68028

(S)-cystathionine ketimine + NADH + 2 H(+) = (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NAD(+)

Left to rightBalancedRhea 68032

(S)-cystathionine ketimine + NADPH + 2 H(+) = (3R,5S)-2,3,5,6,7-pentahydro-1,4-thiazepine-3,5-dicarboxylate + NADP(+)

Left to rightBalancedRhea 68036

(R)-lanthionine ketimine + NADPH + 2 H(+) = (3R,5R)-1,4-thiomorpholine-3,5-dicarboxylate + NADP(+)

Left to rightBalancedRhea 68040

an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + GDP-beta-L-fucose = an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-[alpha-L-Fuc-(1->3)]-beta-D-GlcNAc derivative + GDP + H(+)

Left to rightBalance undeterminableRhea 68044

[protein]-D-aspartate + S-adenosyl-L-methionine = [protein]-D-aspartate methyl ester + S-adenosyl-L-homocysteine

Direction not assertedBalance undeterminableRhea 68048

a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + H(+)

ReversibleBalance undeterminableRhea 68052

a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 3'-phospho-ribonucleotide-RNA + H(+)

Left to rightBalance undeterminableRhea 68056

a 14alpha-methyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-hydroxymethyl steroid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Left to rightBalance undeterminableRhea 68060

a 14alpha-hydroxymethyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 14alpha-formyl steroid + oxidized [NADPH--hemoprotein reductase] + 2 H2O + H(+)

Left to rightBalance undeterminableRhea 68064

a 14alpha-formyl steroid + reduced [NADPH--hemoprotein reductase] + O2 = a Delta(14) steroid + formate + oxidized [NADPH--hemoprotein reductase] + H2O + 2 H(+)

Left to rightBalance undeterminableRhea 68068

Delta(2)-thiazoline-2-carboxylate + NADPH + 2 H(+) = L-thiazolidine-2-carboxylate + NADP(+)

Left to rightBalancedRhea 68072

a 3'-end 3'-phospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate

Left to rightBalance undeterminableRhea 68076

a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA + GTP + H2O = a ribonucleotidyl-ribonucleotide-RNA + GMP + diphosphate + H(+)

Left to rightBalance undeterminableRhea 68080

L-histidyl-[RNA ligase] + GTP = N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase] + diphosphate

Left to rightBalance undeterminableRhea 68084

N(pros)-(5'-guanosyl-phosphono)-L-histidyl-[RNA ligase] + a 3'-end 3'-phospho-ribonucleotide-RNA + H(+) = a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + L-histidyl-[RNA ligase]

Left to rightBalance undeterminableRhea 68088

a 3'-terminal ribonucleotide 3'-(5'-diphosphoguanosine)-RNA + a 5'-end dephospho-ribonucleoside-RNA = a ribonucleotidyl-ribonucleotide-RNA + GMP + H(+)

Left to rightBalance undeterminableRhea 68092

a ribonucleotidyl-ribonucleotide-RNA + H2O = a 3'-end ribonucleotide-RNA + a 5'-end 5'-phospho-ribonucleoside-RNA + H(+)

Left to rightBalance undeterminableRhea 68096

xylitol + NAD(+) = L-xylulose + NADH + H(+)

Direction not assertedBalancedRhea 68100

all-trans-zeaxanthin + O2 = (3R)-3-hydroxy-10'-apo-beta-carotenal + (3R)-hydroxy-beta-ionone

Left to rightBalancedRhea 68104

L-glucitol + NAD(+) = keto-L-fructose + NADH + H(+)

Direction not assertedBalancedRhea 68108

propanamide + H2O = propanoate + NH4(+)

Direction not assertedBalancedRhea 68112

a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + a 1,2-diacylglycerol = an acyl-3-O-(beta-D-galactosyl)-sn-glycerol + a triacylglycerol

Direction not assertedBalance undeterminableRhea 68116

a 1,2-diacylglycerol + a fatty acyl-CoA = a triacylglycerol + CoA

Direction not assertedBalance undeterminableRhea 68120

a fatty acyl-[ACP] + a 1,2-diacylglycerol = a triacylglycerol + holo-[ACP]

Direction not assertedBalance undeterminableRhea 68124

phytol + a fatty acyl-CoA = a fatty acid phytyl ester + CoA

Direction not assertedBalance undeterminableRhea 68128

phytol + tetradecanoyl-CoA = tetradecanoate phytyl ester + CoA

Direction not assertedBalancedRhea 68132

acetophenone + NADPH + H(+) = (R)-1-phenylethanol + NADP(+)

Direction not assertedBalancedRhea 68136

2,5-hexanedione + 2 NADPH + 2 H(+) = (2R,5R)-hexanediol + 2 NADP(+)

Direction not assertedBalancedRhea 68140

ethyl 3-oxobutanoate + NADPH + H(+) = ethyl (R)-3-hydroxybutanoate + NADP(+)

Direction not assertedBalancedRhea 68144

2-octanone + NADPH + H(+) = (2R)-octan-2-ol + NADP(+)

Direction not assertedBalancedRhea 68148

a 1,3-diacylglycerol + a fatty acyl-CoA = a triacylglycerol + CoA

Direction not assertedBalance undeterminableRhea 68152

(2E)-geranyl diphosphate + L-glutamate = N-geranyl-L-glutamate + diphosphate

Direction not assertedBalancedRhea 68156

N-geranyl-L-glutamate + reduced [NADPH--hemoprotein reductase] + O2 = N-(8'-hydroxygeranyl)-L-glutamate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 68160

Page 279 of 372