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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

13,851–13,900 of 18,558 reactions from Rhea

1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine
Direction not assertedBalancedRhea 67764
1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine = 1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol
Direction not assertedBalancedRhea 67768
a 5'-end 5'-phospho-ribonucleoside-RNA + H2O = a 5'-end dephospho-ribonucleoside-RNA + phosphate
Direction not assertedBalance undeterminableRhea 67772
a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H2O = a 5'-end dephospho-2'-deoxyribonucleoside-DNA + phosphate
Direction not assertedBalance undeterminableRhea 67776
1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol

? Direction not asserted

Balanced

Rhea 67780

2 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol = 1',3'-bis-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol

Direction not assertedBalancedRhea 67784

2 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol = 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + a cardiolipin

Direction not assertedBalance undeterminableRhea 67788

ribonucleotidyl-uridine-RNA = a 5'-end dephospho-uridine-RNA + a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA

Left to rightBalance undeterminableRhea 67792

a ribonucleotidyl-ribonucleotide-RNA = a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + a 5'-end dephospho-ribonucleoside-RNA

Left to rightBalance undeterminableRhea 67796

N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 2-oxoglutarate + 2 O2 = L-lysyl(27)-[histone H3] + 2 formaldehyde + 2 succinate + 2 CO2

Left to rightBalance undeterminableRhea 67800

N(6)-methyl-L-lysyl(20)-[histone H4] + 2-oxoglutarate + O2 = L-lysyl(20)-[histone H4] + formaldehyde + succinate + CO2

Left to rightBalance undeterminableRhea 67804

L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-methionine = N(6)-methyl-L-lysyl(8)-[histone H2AZ] + S-adenosyl-L-homocysteine + H(+)

Left to rightBalance undeterminableRhea 67808

a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]

Direction not assertedBalance undeterminableRhea 67812

a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate

Direction not assertedBalance undeterminableRhea 67816

1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + 1-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z-hexadecenoyl)-2-hexadecanoyl-sn-glycero-3-phosphocholine + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol

Direction not assertedBalancedRhea 67820

a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H2O = a lipid X + UMP + 2 H(+)

Direction not assertedBalance undeterminableRhea 67824

a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + UDP + H(+)

Direction not assertedBalance undeterminableRhea 67828

N(6)-methyl-L-lysyl(27)-[histone H3] + 2-oxoglutarate + O2 = L-lysyl(27)-[histone H3] + formaldehyde + succinate + CO2

Direction not assertedBalance undeterminableRhea 67832

1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine

Direction not assertedBalancedRhea 67836

a lipid A disaccharide + ATP = a lipid IVA + ADP + H(+)

Direction not assertedBalance undeterminableRhea 67840

a lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = an alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)

Direction not assertedBalance undeterminableRhea 67844

(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + ATP + CoA = (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoyl-CoA + AMP + diphosphate

Left to rightBalancedRhea 67848

FMNH2 + O2 = FMN-N(5)-peroxide

Direction not assertedBalancedRhea 67852

3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + 3'-phosphoadenylyl sulfate = 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalance undeterminableRhea 67856

a 3-O-{N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + 3'-phosphoadenylyl sulfate = a 3-O-{6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalance undeterminableRhea 67860

a 3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + 3'-phosphoadenylyl sulfate = 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalance undeterminableRhea 67864

3-O-{beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + 3'-phosphoadenylyl sulfate = 3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalance undeterminableRhea 67868

3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP-alpha-D-galactose = 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-threonyl-[protein] + UDP + H(+)

Left to rightBalance undeterminableRhea 67872

3,3',5-triiodo-L-thyronine + 3'-phosphoadenylyl sulfate = 3,3',5-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalancedRhea 67876

dopamine + 3'-phosphoadenylyl sulfate = dopamine 3-O-sulfate + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalancedRhea 67880

dopamine + 3'-phosphoadenylyl sulfate = dopamine 4-O-sulfate + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalancedRhea 67884

3,3',5'-triiodo-L-thyronine + 3'-phosphoadenylyl sulfate = 3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalancedRhea 67888

3,3'-diiodo-L-thyronine + 3'-phosphoadenylyl sulfate = 3,3'-diiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalancedRhea 67892

a 3'-end uridylyl-adenosine-RNA = a 3'-end 2',3'-cyclophospho-uridine-RNA + adenosine

Left to rightBalance undeterminableRhea 67896

glutarate + succinyl-CoA = glutaryl-CoA + succinate

ReversibleBalancedRhea 67900

glutaryl-CoA + malonyl-[ACP] + H(+) = 3-oxo-6-carboxyhexanoyl-[ACP] + CO2 + CoA

Direction not assertedBalance undeterminableRhea 67904

a primary linear alkyl sulfate ester + H2O = a primary alcohol + sulfate + H(+)

Direction not assertedBalance undeterminableRhea 67908

[protein]-C-terminal L-amino acid-glycyl-phosphatidylserine + H2O = 1,2-diacyl-sn-glycero-3-phospho-L-serine-N-glycine + [protein]-C-terminal L-amino acid

Direction not assertedBalance undeterminableRhea 67912

adenosine 5'-phosphoramidate + H2O = NH4(+) + AMP

Direction not assertedBalancedRhea 67916

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)

Direction not assertedBalance undeterminableTransportRhea 67920

3-O-{(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP-alpha-D-glucuronate = 3-O-{beta-D-GlcA-(1->[3)-alpha-D-Xyl-(1->3)-beta-D-GlcA-(1->](n)-4)-beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-O-6-P-alpha-D-Man}-L-Thr-[protein] + UDP + H(+)

Left to rightBalance undeterminableRhea 67924

a 3'-end 2',3'-cyclophospho-uridine-RNA + H2O = a 3'-end 3'-phosphouridine-RNA + H(+)

Direction not assertedBalance undeterminableRhea 67928

desmosterol(in) + ATP + H2O = desmosterol(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 67932

a 2-hydroxy carboxylate + O2 = a 2-oxocarboxylate + H2O2

Direction not assertedBalance undeterminableRhea 67936

2-hydroxyoctanoate + O2 = 2-oxooctanoate + H2O2

Left to rightBalancedRhea 67940

2-hydroxyhexadecanoate + O2 = 2-oxohexadecanoate + H2O2

Left to rightBalancedRhea 67944

3-O-{beta-D-galactosyl-(1->3)-[6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP-alpha-D-galactose = 3-O-{beta-D-galactosyl-(1->3)-[beta-D-galactosyl-(1->4)-6-O-sulfo-N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-alpha-D-galactosaminyl}-L-seryl-[protein] + UDP + H(+)

Left to rightBalance undeterminableRhea 67948

an omega-methyl-very-long-chain fatty acid + reduced [NADPH--hemoprotein reductase] + O2 = an omega-hydroxy-very-long-chain fatty acid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 67952

(S)-2-chloropropanoate + H2O = (R)-lactate + chloride + H(+)

Direction not assertedBalancedRhea 67956

4-amino-L-phenylalanine + S-adenosyl-L-methionine = 4-methylamino-L-phenylalanine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 67960

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