Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

13,751–13,800 of 18,558 reactions from Rhea

(2S)-naringenin 7-O-beta-D-glucoside + malonyl-CoA = (2S)-naringenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA
Direction not assertedBalancedRhea 67356
L-threonyl-L-threonine + H2O = 2 L-threonine
Left to rightBalancedRhea 67360
L-threonyl-L-serine + H2O = L-threonine + L-serine
Left to rightBalancedRhea 67364
N-acetyl-L-glutamine + H2O = L-glutamine + acetate
Left to rightBalancedRhea 67368
L-seryl-L-threonine + H2O = L-threonine + L-serine
Left to rightBalancedRhea 67372
glycyl-L-histidine + H2O = L-histidine + glycine
Left to rightBalancedRhea 67376
L-alanyl-L-cysteine + H2O = L-cysteine + L-alanine
Left to right

Balanced

Rhea 67380

5beta-cholestane-3alpha,7alpha-diol + reduced [NADPH--hemoprotein reductase] + O2 = 5beta-cholestane-3alpha,7alpha,25-triol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 67384

L-cysteinyl-[myelin proteolipid protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[myelin proteolipid protein] + CoA

Direction not assertedBalance undeterminableRhea 67388

2-oxo-ATP + H2O = 2-oxo-AMP + diphosphate + H(+)

Left to rightBalancedRhea 67392

5beta-cholestane-3alpha,7alpha,12alpha-triol + reduced [NADPH--hemoprotein reductase] + O2 = 5beta-cholestane-3alpha,7alpha,12alpha,25-tetrol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 67396

(2E,6E)-farnesyl diphosphate = allo-aromadendrene + diphosphate

Direction not assertedBalancedRhea 67400

gamma-terpinene + 2 reduced [NADPH--hemoprotein reductase] + 2 O2 = carvacrol + 2 oxidized [NADPH--hemoprotein reductase] + 3 H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 67404

gamma-terpinene + 2 reduced [NADPH--hemoprotein reductase] + 2 O2 = thymol + 2 oxidized [NADPH--hemoprotein reductase] + 3 H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 67408

alpha-terpinene + 2 reduced [NADPH--hemoprotein reductase] + 2 O2 = carvacrol + 2 oxidized [NADPH--hemoprotein reductase] + 3 H2O + 2 H(+)

Direction not assertedBalance undeterminableRhea 67412

(4R)-limonene + reduced [NADPH--hemoprotein reductase] + O2 = (1R,6S)-isopiperitenol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 67416

a glycerophospholipid + H2O = a 1-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)

Direction not assertedBalance undeterminableRhea 67420

a glycerophospholipid + H2O = a 2-acyl-sn-glycero-3-phospholipid + a fatty acid + H(+)

Direction not assertedBalance undeterminableRhea 67424

a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)

Left to rightBalance undeterminableRhea 67428

1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine

Direction not assertedBalancedRhea 67432

1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine = 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine

Direction not assertedBalancedRhea 67436

N-acetyl-L-methionine + H2O = L-methionine + acetate

Left to rightBalancedRhea 67440

an (R)-2-hydroxy-long-chain-fatty acyl-CoA = a long-chain fatty aldehyde + formyl-CoA

Left to rightBalance undeterminableRhea 67444

(2R)-2-hydroxyoctadecanoyl-CoA = heptadecanal + formyl-CoA

Direction not assertedBalancedRhea 67448

a 4-O-methyl-alpha-D-glucuronosyl ester derivative + H2O = 4-O-methyl-alpha-D-glucuronate derivative + an alcohol + H(+)

Direction not assertedBalance undeterminableRhea 67452

1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol = 1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol

Direction not assertedBalancedRhea 67456

(R)-malate + A = oxaloacetate + AH2

Left to rightBalancedRhea 67460

propanoyl-CoA + H2O = propanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Left to rightBalancedRhea 67464

malonyl-CoA + H2O = malonyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Left to rightBalancedRhea 67468

succinyl-CoA + H2O = succinyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Left to rightBalancedRhea 67472

dimethylallyl diphosphate + L-glutamate = prekainate + diphosphate

Direction not assertedBalancedRhea 67476

prekainate + 2-oxoglutarate + O2 = kainate + succinate + CO2 + H2O

Direction not assertedBalancedRhea 67480

a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + H2O = N(7)-methyl-GDP + a 5'-end phospho-ribonucleoside in mRNA + 2 H(+)

Left to rightBalance undeterminableRhea 67484

1-tetradecanoyl-sn-glycero-3-phosphocholine + 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol = 1-tetradecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol

Direction not assertedBalancedRhea 67488

a 5'-end FAD-phospho-ribonucleoside in mRNA + H2O = a 5'-end phospho-ribonucleoside in mRNA + FAD + H(+)

Left to rightBalance undeterminableRhea 67492

a 5'-end CoA-ribonucleoside in mRNA + H2O = 3'-dephospho-CoA + a 5'-end phospho-ribonucleoside in mRNA + H(+)

Left to rightBalance undeterminableRhea 67496

1,2-di-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-tetradecanoyl-sn-glycero-3-phosphocholine = 1-tetradecanoyl-2-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + 1-(9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine

Direction not assertedBalancedRhea 67500

1-nonadecanoyl-sn-glycero-3-phosphocholine + 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine = 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-octadecanoyl-sn-glycero-3-phosphocholine

Direction not assertedBalancedRhea 67504

1-(9Z)-octadecenoyl-2-octadecanoyl-sn-glycero-3-phosphocholine + 1-nonadecanoyl-sn-glycero-3-phosphocholine = 2-octadecanoyl-sn-glycero-3-phosphocholine + 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine

Direction not assertedBalancedRhea 67508

1-nonadecanoyl-sn-glycero-3-phosphocholine + 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol = 1-nonadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol

Direction not assertedBalancedRhea 67512

1-nonadecanoyl-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) = 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)

Direction not assertedBalancedRhea 67516

1',3'-bis[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol + 1-nonadecanoyl-sn-glycero-3-phosphocholine = 1-nonadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + 1'-[1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phospho]-3'-[1-(9Z-octadecenoyl)-sn-glycero-3-phospho]-glycerol

Direction not assertedBalancedRhea 67520

4,8-dimethylnonanoyl-CoA + H2O = S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Left to rightBalancedRhea 67524

(6Z)-octenoyl-CoA + H2O = S-(6Z-octenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Left to rightBalancedRhea 67528

(9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O = S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Left to rightBalancedRhea 67532

(9Z,12Z)-octadecadienoyl-CoA + H2O = S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Left to rightBalancedRhea 67536

(9Z)-hexadecenoyl-CoA + H2O = S-(9Z-hexadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Left to rightBalancedRhea 67540

(9Z)-tetradecenoyl-CoA + H2O = S-(9Z-tetradecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)

Left to rightBalancedRhea 67544

[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine

Left to rightBalance undeterminableRhea 67548

cholate + 3'-phosphoadenylyl sulfate = cholate 7-sulfate + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalancedRhea 67552

Page 276 of 372