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ReactionsRhea and Human-GEM, by subsystem
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Reference

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

13,701–13,750 of 18,558 reactions from Rhea

1-O-(1Z-hexadecenyl)-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(1Z-hexadecenyl)-sn-glycero-3-phosphocholine + (9Z)-octadecenoate + H(+)
Left to rightBalancedRhea 67156
melleolide F + FADH2 + chloride + O2 = 6'-chloromelleolide F + FAD + 2 H2O + H(+)
Direction not assertedBalancedRhea 67160
melleolide F + bromide + FADH2 + O2 = 6'-bromomelleolide F + FAD + 2 H2O
Direction not assertedBalancedRhea 67164
3-hydroxy-L-phenylalanine + 2-oxoglutarate = 3-(3-hydroxyphenyl)pyruvate + L-glutamate
Direction not assertedBalancedRhea 67168
primary fluorescent chlorophyll catabolite + reduced [NADPH--hemoprotein reductase] + O2 = primary fluorescent dioxobilin-type chlorophyll catabolite + formate + oxidized [NADPH--hemoprotein reductase] + 2 H(+)
Direction not assertedBalance undeterminableRhea 67172
primary fluorescent dioxobilin-type chlorophyll catabolite + H2O = O13(4)-desmethyl pFDCC + methanol + H(+)
Direction not asserted

Balanced

Rhea 67176

L-glutamyl-[protein] + glycine + ATP = glycyl-L-glutamyl-[protein] + ADP + phosphate + H(+)

Left to rightBalance undeterminableRhea 67180

(glycyl)(n)-glycyl-L-glutamyl-[protein] + glycine + ATP = (glycyl)(n+1)-glycyl-L-glutamyl-[protein] + ADP + phosphate + H(+)

Direction not assertedBalance undeterminableRhea 67184

an N-all-trans-retinylidenephosphatidylethanolamine(out) + ATP + H2O = an N-all-trans-retinylidenephosphatidylethanolamine(in) + ADP + phosphate + H(+)

Left to rightBalance undeterminableTransportRhea 67188

N-11-cis-retinylidenephosphatidylethanolamine(out) + ATP + H2O = N-11-cis-retinylidenephosphatidylethanolamine(in) + ADP + phosphate + H(+)

Left to rightBalance undeterminableTransportRhea 67192

N-acetylserotonin + H2O = serotonin + acetate

Direction not assertedBalancedRhea 67196

N-acetyltyramine + H2O = tyramine + acetate

Direction not assertedBalancedRhea 67200

N-acetyltryptamine + H2O = tryptamine + acetate

Direction not assertedBalancedRhea 67204

melatonin + H2O = 5-methoxytryptamine + acetate

Direction not assertedBalancedRhea 67208

(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + O2 = (2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O2

Direction not assertedBalancedRhea 67212

(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA = (2E,4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-2,4,8-trienoyl-CoA + H2O

Direction not assertedBalancedRhea 67216

(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-4,8-dimethyldeca-4,8-dienoyl-CoA + NAD(+) = (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + NADH + H(+)

Direction not assertedBalancedRhea 67220

(2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + acetyl-CoA = (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-4,8-dimethyldeca-4,8-dienoyl-CoA + CoA

Direction not assertedBalancedRhea 67224

(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA = (2E,6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-2,6-dimethylocta-2,6-dienoyl-CoA + H2O

Direction not assertedBalancedRhea 67228

(6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-(3R)-hydroxy-2,6-dimethyloct-6-enoyl-CoA + NAD(+) = (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + NADH + H(+)

Direction not assertedBalancedRhea 67232

mycophenolyl-CoA + propanoyl-CoA = (6E)-8-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-3-oxo-2,6-dimethyloct-6-enoyl-CoA + CoA

Direction not assertedBalancedRhea 67236

(R)-S-adenosyl-L-methionine + H2O = adenosine + L-methionine + H(+)

Direction not assertedBalancedRhea 67240

3-deoxyglucosone + NAD(+) + H2O = 2-dehydro-3-deoxy-D-gluconate + NADH + 2 H(+)

Left to rightBalancedRhea 67244

(E)-4-hydroxynon-2-enal + NAD(+) + H2O = (E)-4-hydroxynon-2-enoate + NADH + 2 H(+)

Left to rightBalancedRhea 67248

malonaldehyde + NAD(+) + H2O = 3-oxopropanoate + NADH + 2 H(+)

Left to rightBalancedRhea 67252

propanal + NAD(+) + H2O = propanoate + NADH + 2 H(+)

Left to rightBalancedRhea 67256

(E)-hept-2-enal + NAD(+) + H2O = (E)-hept-2-enoate + NADH + 2 H(+)

Direction not assertedBalancedRhea 67260

(2S,4S)-4-hydroxy-4-methylglutamate + 8 malonyl-CoA + 3 S-adenosyl-L-methionine + ATP + 8 NADPH + 11 H(+) = (2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 3 S-adenosyl-L-homocysteine + 8 CO2 + diphosphate + 8 NADP(+) + 8 CoA + 6 H2O

Direction not assertedBalancedRhea 67264

(2S)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate = sch 210972

Direction not assertedBalancedRhea 67268

1'-[1-acyl-2-(9-hydroxy-(10E,12Z)-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1,2-diacyl-sn-glycero-3-phospho]-glycerol + H2O = 9-hydroxy-(10E,12Z)-octadecadienoate + 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + H(+)

Left to rightBalance undeterminableRhea 67272

hexanal + NAD(+) + H2O = hexanoate + NADH + 2 H(+)

Left to rightBalancedRhea 67276

(2R,4S,6E,8E,10E)-1-(4-methoxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione = (1R,3R,6S,7E,10S,12R)-17-methoxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione

Direction not assertedBalancedRhea 67280

(2R,4S,6E,8E,10E)-1-(4-hydroxy-5-methylidene-2-oxo-2,5-dihydrofuran-3-yl)-2,4-dimethyldodeca-6,8,10-triene-1,5-dione = (1R,3R,6S,7E,10S,12R)-17-hydroxy-3,10,12-trimethyl-16-oxatricyclo[12.2.1.0(1,6)]heptadeca-4,7,14(17)-triene-9,13,15-trione

Direction not assertedBalancedRhea 67284

L-leucine + 8 malonyl-CoA + 4 S-adenosyl-L-methionine + ATP + 9 NADPH + 12 H(+) = (5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + AMP + 4 S-adenosyl-L-homocysteine + 8 CO2 + diphosphate + 9 NADP(+) + 8 CoA + 7 H2O

Direction not assertedBalancedRhea 67288

(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one = (3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one

Direction not assertedBalancedRhea 67292

(3Z)-3-[(2E,6R,8E,10E,12E)-1-hydroxy-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraen-1-ylidene]-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 = (5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one + H2O2

Direction not assertedBalancedRhea 67296

(5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one = 3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one

Direction not assertedBalancedRhea 67300

3-{[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl](hydroxy)methylidene}-5-(2-methylpropyl)-2,3-dihydro-1H-pyrrol-2-one + O2 = myceliothermophin E + H2O2

Direction not assertedBalancedRhea 67304

(5S)-5-(2-methylpropyl)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one = (5S)-3-[(1S,2R,4aR,6R,8aS)-2-(but-2-en-2-yl)-3,4a,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-5-(2-methylpropyl)-2,5-dihydro-1H-pyrrol-2-one

Direction not assertedBalancedRhea 67308

(5Z)-5-(2-methylpropylidene)-3-[(2E,6R,8E,10E,12E)-6,8,10,12-tetramethyltetradeca-2,8,10,12-tetraenoyl]-2,5-dihydro-1H-pyrrol-2-one = myceliothermophin E

Direction not assertedBalancedRhea 67312

(2S,4R)-4-hydroxy-4-methylglutamate + 8 malonyl-CoA + 3 S-adenosyl-L-methionine + ATP + 8 NADPH + 11 H(+) = (2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate + AMP + 3 S-adenosyl-L-homocysteine + 8 CO2 + diphosphate + 8 NADP(+) + 8 CoA + 6 H2O

Direction not assertedBalancedRhea 67316

(2R)-3-[(2S)-3,5-dioxo-4-[(2E,4R,6R,8E,10E,12E)-4,6,12-trimethyltetradeca-2,8,10,12-tetraenoyl]pyrrolidin-2-yl]-2-hydroxy-2-methylpropanoate = sch 210971

Direction not assertedBalancedRhea 67320

L-serine + 7 malonyl-CoA + acetyl-CoA + 2 S-adenosyl-L-methionine + ATP + 8 NADPH + 11 H(+) = (5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione + AMP + 2 S-adenosyl-L-homocysteine + 7 CO2 + diphosphate + 8 NADP(+) + 8 CoA + 6 H2O

Direction not assertedBalancedRhea 67324

(5S)-3-[(2E,6R,8E,10E,12E)-2,6-dimethyltetradeca-2,8,10,12-tetraenoyl]-5-(hydroxymethyl)pyrrolidine-2,4-dione = trichosetin

Direction not assertedBalancedRhea 67328

13-cis-retinal + NAD(+) + H2O = 13-cis-retinoate + NADH + 2 H(+)

Left to rightBalancedRhea 67332

kaempferol 3-O-beta-D-glucoside + malonyl-CoA = kaempferol 3-O-(6-O-malonyl-beta-D-glucoside) + CoA

Direction not assertedBalancedRhea 67336

quercetin 3-O-beta-D-glucoside + malonyl-CoA = quercetin 3-O-(6-O-malonyl-beta-D-glucoside) + CoA

Direction not assertedBalancedRhea 67340

kaempferol 7-O-beta-D-glucoside + malonyl-CoA = kaempferol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA

Direction not assertedBalancedRhea 67344

apigenin 7-O-beta-D-glucoside + malonyl-CoA = apigenin 7-O-(6-O-malonyl-beta-D-glucoside) + CoA

Direction not assertedBalancedRhea 67348

rhaponticin + malonyl-CoA = 6-O-malonyl-rhaponticin + CoA

Direction not assertedBalancedRhea 67352

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