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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

13,551–13,600 of 18,558 reactions from Rhea

L-glutaminyl-[protein] + serotonin = 5-serotonyl-L-glutamyl-[protein] + NH4(+)
Left to rightBalance undeterminableRhea 66552
L-glutaminyl-[protein] + dopamine = 5-dopaminyl-L-glutamyl-[protein] + NH4(+)
Left to rightBalance undeterminableRhea 66556
L-glutaminyl-[protein] + (R)-noradrenaline = 5-(R)-noradrenalinyl-L-glutamyl-[protein] + NH4(+)
Left to rightBalance undeterminableRhea 66560
L-glutaminyl-[protein] + histamine = 5-histaminyl-L-glutamyl-[protein] + NH4(+)
Left to rightBalance undeterminableRhea 66564
(2E,6E,10E,14E)-geranylfarnesol + H2O = preluffariellolide A
Direction not assertedBalancedRhea 66568
2-naphthol + 3'-phosphoadenylyl sulfate = 2-naphthyl sulfate + adenosine 3',5'-bisphosphate + H(+)
Direction not assertedBalancedRhea 66572
4-isopropylphenol + 3'-phosphoadenylyl sulfate = 4-isopropylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+)

Direction not assertedBalancedRhea 66576

bisphenol A + 3'-phosphoadenylyl sulfate = bisphenyl A sulfate + adenosine 3',5'-bisphosphate + H(+)

Left to rightBalancedRhea 66580

3-oxocholestane + A + H2O = 25-hydroxy 3-oxocholestane + AH2

Direction not assertedBalancedRhea 66584

a cytidine in 26S rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in 26S rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 66588

2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)

Left to rightBalance undeterminableRhea 66592

2 tyramine + O2 = 2 dopamine

Direction not assertedBalancedRhea 66596

2 dopamine + O2 = 2 dopamine quinone + 2 H2O

Direction not assertedBalancedRhea 66600

a 2'-deoxycytidine in double-stranded DNA + H2O + H(+) = a 2'-deoxyuridine in double-stranded DNA + NH4(+)

Direction not assertedBalance undeterminableRhea 66604

(tRNA)-3'-end (ribonucleoside 5'-phosphate)-(guanosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(cytosyl 5'-phosphate)-(adenosine 5'-phosphate) + H2O = GpCpCpA + tRNA 3'-end (ribonucleotide 3'-phosphate) + H(+)

Direction not assertedBalance undeterminableRhea 66608

N(6)-carboxybiotinyl-L-lysyl-[protein] + propanoyl-CoA = methylmalonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]

Direction not assertedBalance undeterminableRhea 66612

Mg(2+)(in) + 2 Na(+)(out) = Mg(2+)(out) + 2 Na(+)(in)

Left to rightBalancedTransportRhea 66616

5alpha-cholest-7-en-3-one + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = (25S)-Delta7-dafachronate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)

Direction not assertedBalance undeterminableRhea 66620

cholest-4-en-3-one + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = (25S)-3-oxocholest-4-en-26-oate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)

Direction not assertedBalance undeterminableRhea 66624

(2S,4S,5S)-2-amino-6-(3,4-dihydroxyphenyl)-4-hydroxy-5-(methylamino)hexanoyl-[peptidyl-carrier protein] + O2 = (2S,4S)-2-amino-4-[(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl]-4-hydroxybutanoyl-[peptidyl-carrier protein] + H2O2

Direction not assertedBalance undeterminableRhea 66628

L-arginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(omega)-(N-acetyl-beta-D-glucosaminyl)-L-arginyl-[protein] + UDP + H(+)

Direction not assertedBalance undeterminableRhea 66632

(2E,6E)-farnesyl diphosphate + H2O = (-)-alpha-acorenol + diphosphate

Direction not assertedBalancedRhea 66636

(2E,6E)-farnesyl diphosphate + H2O = koraiol + diphosphate

Direction not assertedBalancedRhea 66640

(2E,6E)-farnesyl diphosphate + H2O = trichobrasilenol + diphosphate

Direction not assertedBalancedRhea 66644

(2E,6E)-farnesyl diphosphate = african-3-ene + diphosphate

Direction not assertedBalancedRhea 66648

(2E,6E)-farnesyl diphosphate = african-1-ene + diphosphate

Direction not assertedBalancedRhea 66652

Cu(2+)(out) + L-ascorbate(in) = Cu(+)(out) + monodehydro-L-ascorbate radical(in) + H(+)

Direction not assertedBalancedRhea 66656

a beta-D-glucosylceramide(in) + ATP + H2O = a beta-D-glucosylceramide(out) + ADP + phosphate + H(+)

Left to rightBalance undeterminableTransportRhea 66660

coproporphyrin III(in) + ATP + H2O = coproporphyrin III(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 66664

5-methylorsellinate + reduced [NADPH--hemoprotein reductase] + O2 = 4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 66668

4,6-dihydroxy-2-(hydroxymethyl)-3-methylbenzoate + H(+) = 5,7-dihydroxy-4-methylphthalide + H2O

Direction not assertedBalancedRhea 66672

5,7-dihydroxy-4-methylphthalide + (2E,6E)-farnesyl diphosphate = 4-farnesyl-3,5-dihydroxy-6-methylphthalide + diphosphate

Direction not assertedBalancedRhea 66676

coproporphyrinogen III(in) + ATP + H2O = coproporphyrinogen III(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 66680

S-nitroso-L-cysteinyl-[GAPDH] + L-cysteinyl-[protein] = L-cysteinyl-[GAPDH] + S-nitroso-L-cysteinyl-[protein]

Left to rightBalance undeterminableRhea 66684

4-farnesyl-3,5-dihydroxy-6-methylphthalide + AH2 + 2 O2 = (4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + acetone + A + H2O + H(+)

Direction not assertedBalancedRhea 66688

dTDP-beta-L-rhamnose + L-arginyl-[protein] = N(omega)-(alpha-L-rhamnosyl)-L-arginyl-[protein] + dTDP + H(+)

Direction not assertedBalance undeterminableRhea 66692

(4E,8E)-10-(4,6-dihydroxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-methionine = (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 66696

(4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoate + ATP + CoA = (4E,8E)-10-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4,8-dimethyldeca-4,8-dienoyl-CoA + AMP + diphosphate

Direction not assertedBalancedRhea 66700

mycophenolyl-CoA + H2O = mycophenolate + CoA + H(+)

Direction not assertedBalancedRhea 66704

1,2-dihexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + H2O = 2-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + hexadecanoate + H(+)

Left to rightBalancedRhea 66708

stellata-2,6,19-triene + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = stellatate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)

Direction not assertedBalance undeterminableRhea 66712

6-deoxy-6-sulfo-D-fructose + D-glyceraldehyde 3-phosphate = D-fructose 6-phosphate + (2S)-3-sulfolactaldehyde

Direction not assertedBalancedRhea 66716

N-[(S)-lactoyl]-L-phenylalanine(in) + ATP + H2O = N-[(S)-lactoyl]-L-phenylalanine(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 66720

(S)-lactate + L-phenylalanine = N-[(S)-lactoyl]-L-phenylalanine + H2O

ReversibleBalancedRhea 66724

N-acetyl-L-aspartyl-L-glutamate(in) + ATP + H2O = N-acetyl-L-aspartyl-L-glutamate(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 66728

N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(in) + ATP + H2O = N-acetyl-L-aspartyl-L-glutamyl-L-glutamate(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 66732

beta-citrylglutamate(in) + ATP + H2O = beta-citrylglutamate(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 66736

N-acetyl-L-glutamate(in) + ATP + H2O = N-acetyl-L-glutamate(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 66740

N-acetyl-L-aspartate(in) + ATP + H2O = N-acetyl-L-aspartate(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 66744

(2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(in) + ATP + H2O = (2S)-2-[5-amino-1-(beta-D-ribosyl)imidazole-4-carboxamido]succinate(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 66752

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