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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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Reference

Evidence

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Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

13,401–13,450 of 18,558 reactions from Rhea

a 2'-deoxyadenosine in DNA + acetyl-CoA + AH2 + NH4(+) + O2 = a N(6)-methylcarbamoyl-2'-deoxyadenosine in DNA + A + CoA + 2 H2O + H(+)
Direction not assertedBalance undeterminableRhea 65948
2 a quinone + NADH + H(+) = 2 a 1,4-benzosemiquinone + NAD(+)
Direction not assertedBalance undeterminableRhea 65952
estrone 3-sulfate(out) + ATP + H2O = estrone 3-sulfate(in) + ADP + phosphate + H(+)
Left to rightBalancedTransportRhea 65956
leukotriene C4(out) + ATP + H2O = leukotriene C4(in) + ADP + phosphate + H(+)
Left to rightBalancedTransportRhea 65960
taurocholate(out) + ATP + H2O = taurocholate(in) + ADP + phosphate + H(+)
Left to rightBalancedTransportRhea 65964
17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ADP + phosphate + H(+)
Left to rightBalancedTransportRhea

65968

a peptide antigen(in) + ATP + H2O = a peptide antigen(out) + ADP + phosphate + H(+)

Left to rightBalance undeterminableTransportRhea 65972

7-dehydrocholesterol + hnu = previtamin D3

Direction not assertedBalance undeterminableRhea 65976

previtamin D3 + hnu = tachysterol 3

Direction not assertedBalance undeterminableRhea 65980

previtamin D3 + hnu = lumisterol 3

Direction not assertedBalance undeterminableRhea 65984

previtamin D3 = calciol

Direction not assertedBalancedRhea 65988

calciol + hnu = 5,6-trans-vitamin D3

Direction not assertedBalance undeterminableRhea 65992

Co(I)-[glycine betaine-specific corrinoid protein] + glycine betaine + H(+) = methyl-Co(III)-[glycine betaine-specific corrinoid protein] + N,N-dimethylglycine

Direction not assertedBalance undeterminableRhea 65996

methyl-Co(III)-[glycine betaine-specific corrinoid protein] + (6S)-5,6,7,8-tetrahydrofolate = Co(I)-[glycine betaine-specific corrinoid protein] + (6S)-5-methyl-5,6,7,8-tetrahydrofolate + H(+)

Direction not assertedBalance undeterminableRhea 66000

methyl-Co(III)-[glycine betaine-specific corrinoid protein] + coenzyme M = Co(I)-[glycine betaine-specific corrinoid protein] + methyl-coenzyme M + H(+)

Direction not assertedBalance undeterminableRhea 66004

(5R)-5-hydroxy-L-lysyl-[collagen] + L-methionyl-[collagen] + H2O2 = [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + 2 H2O + H(+)

Direction not assertedBalance undeterminableRhea 66008

(5R)-5-hydroxy-L-lysyl-[collagen] + L-methionyl-[collagen] + hypobromite = [collagen]-(5R)-5-hydroxy-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H2O + H(+)

Direction not assertedBalance undeterminableRhea 66012

bromide + H2O2 = hypobromite + H2O

Left to rightBalancedRhea 66016

L-lysyl-[collagen] + L-methionyl-[collagen] + H2O2 = [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + 2 H2O + H(+)

Left to rightBalance undeterminableRhea 66020

L-lysyl-[collagen] + L-methionyl-[collagen] + hypobromite = [collagen]-L-lysyl-N-S-L-methionyl-[collagen] + bromide + H2O + H(+)

Left to rightBalance undeterminableRhea 66024

L-arginyl-[methyl-coenzyme M reductase] + AH2 + 2 S-adenosyl-L-methionine = (5S)-C-methyl-L-arginyl-[methyl-coenzyme M reductase] + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)

Direction not assertedBalance undeterminableRhea 66028

GDP-alpha-D-glucose + alpha-D-mannose 1-phosphate = alpha-D-glucose 1-phosphate + GDP-alpha-D-mannose

Direction not assertedBalancedRhea 66032

a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)

Left to rightBalance undeterminableTransportRhea 66036

(9Z,12Z)-octadecadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z,12Z,15Z)-octadecatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 66040

2-oxobutanoate + L-kynurenine = (2S)-2-aminobutanoate + kynurenate + H2O

Left to rightBalancedRhea 66044

2-oxobutanoate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + (2S)-2-aminobutanoate

Direction not assertedBalancedRhea 66048

indole-3-pyruvate + L-kynurenine = kynurenate + L-tryptophan + H2O

Left to rightBalancedRhea 66052

indole-3-pyruvate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tryptophan

Direction not assertedBalancedRhea 66056

2-oxohexanoate + L-kynurenine = L-2-aminohexanoate + kynurenate + H2O

Left to rightBalancedRhea 66060

2-oxohexanoate + L-kynurenine = L-2-aminohexanoate + 4-(2-aminophenyl)-2,4-dioxobutanoate

Direction not assertedBalancedRhea 66064

4-methyl-2-oxopentanoate + L-kynurenine = kynurenate + L-leucine + H2O

Left to rightBalancedRhea 66068

4-methyl-2-oxopentanoate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-leucine

Direction not assertedBalancedRhea 66072

2-oxopentanoate + L-kynurenine = L-2-aminopentanoate + kynurenate + H2O

Left to rightBalancedRhea 66076

2-oxopentanoate + L-kynurenine = L-2-aminopentanoate + 4-(2-aminophenyl)-2,4-dioxobutanoate

Direction not assertedBalancedRhea 66080

L-kynurenine + oxaloacetate = kynurenate + L-aspartate + H2O

Direction not assertedBalancedRhea 66084

L-kynurenine + oxaloacetate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate

Direction not assertedBalancedRhea 66088

3-phenylpyruvate + L-kynurenine = kynurenate + L-phenylalanine + H2O

Left to rightBalancedRhea 66092

3-phenylpyruvate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-phenylalanine

Direction not assertedBalancedRhea 66096

3-(4-hydroxyphenyl)pyruvate + L-kynurenine = kynurenate + L-tyrosine + H2O

Direction not assertedBalancedRhea 66100

3-(4-hydroxyphenyl)pyruvate + L-kynurenine = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-tyrosine

Direction not assertedBalancedRhea 66104

2-oxobutanoate + L-cysteine = 2-oxo-3-sulfanylpropanoate + (2S)-2-aminobutanoate

Direction not assertedBalancedRhea 66108

2-oxobutanoate + L-tyrosine = (2S)-2-aminobutanoate + 3-(4-hydroxyphenyl)pyruvate

Direction not assertedBalancedRhea 66112

2-oxobutanoate + L-glutamine = 2-oxoglutaramate + (2S)-2-aminobutanoate

Direction not assertedBalancedRhea 66116

2-oxobutanoate + L-methionine = (2S)-2-aminobutanoate + 4-methylsulfanyl-2-oxobutanoate

Direction not assertedBalancedRhea 66120

2-oxobutanoate + L-histidine = 3-(imidazol-5-yl)pyruvate + (2S)-2-aminobutanoate

Direction not assertedBalancedRhea 66124

2-oxobutanoate + L-phenylalanine = (2S)-2-aminobutanoate + 3-phenylpyruvate

Direction not assertedBalancedRhea 66128

a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)

Left to rightBalance undeterminableTransportRhea 66132

tyramine + acetyl-CoA = N-acetyltyramine + CoA + H(+)

Direction not assertedBalancedRhea 66136

octopamine + acetyl-CoA = N-acetyloctopamine + CoA + H(+)

Direction not assertedBalancedRhea 66140

5-methoxytryptamine + acetyl-CoA = melatonin + CoA + H(+)

Direction not assertedBalancedRhea 66144

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