Skip to content

Reference

Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
ArticlesReadings of the evidence

Chemistry

ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
ProcessesWhat proteins are annotated as doing
AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
OrganismsSpecies a compound is prepared from
MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

Atlas Graph Twin Access

Search the graph

Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

Loading the page.

Catalyst

Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

The graph

Compounds
Outcomes
Proteins
Atlas
Interactions
Papers
Articles
Graph
Search

Reference layer

Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases
Reactions
Reach

How it works

Mission
Method
Twin
How to read the evidence
Sources and licences

Build on it

Access
In your assistant
For agents
Query the graph
Bulk export

A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

13,351–13,400 of 18,558 reactions from Rhea

dodecyl sulfate + 2-oxoglutarate + O2 = dodecanal + sulfate + succinate + CO2 + H(+)
Direction not assertedBalancedRhea 65748
L-glutamate + 2-oxoglutarate + O2 = (3R)-3-hydroxy-L-glutamate + succinate + CO2
Direction not assertedBalancedRhea 65752
N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 2 Fe(3+) + 4 H2O = L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 3-oxopropanoate + 2 Fe(2+) + 2 H(+)
Direction not assertedBalance undeterminableRhea 65756
a C21-steroid + reduced [NADPH--hemoprotein reductase] + O2 = a 17alpha-hydroxy-C21-steroid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Left to rightBalance undeterminableRhea 65760
a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + H2O = (2E,4S)-4,5-dihydroxypent-2-enal + a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + H(+)
Direction not assertedBalance undeterminableRhea 65764

a 1,1-dimethyl-3-phenylurea + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 1-methyl-3-phenylurea + formaldehyde + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 65768

isoproturon + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = 1-methyl-3-[4-(propan-2-yl)phenyl]urea + formaldehyde + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 65772

chlorotoluron + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = 3-(3-chloro-4-methylphenyl)-1-methylurea + formaldehyde + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 65776

metoxuron + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = 3-(3-chloro-4-methoxylphenyl)-1-methylurea + formaldehyde + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 65780

monuron + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = 3-(4-chlorophenyl)-1-methylurea + formaldehyde + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 65784

diuron + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = 3-(3,4-dichlorophenyl)-1-methylurea + formaldehyde + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 65788

fluometuron + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = 3-[3-(trifluoromethyl)phenyl]-1-methylurea + formaldehyde + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 65792

fenuron + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = 1-methyl-3-phenylurea + formaldehyde + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 65796

a 3'-end 2'-deoxyribonucleotide-3'-(L-tyrosyl phosphate)-DNA + H2O = a 3'end (2'-deoxyribonucleotide 3'-phosphate)-DNA + L-tyrosine + H(+)

Direction not assertedBalance undeterminableRhea 65800

a 5'-end L-tyrosylphosphate-2'-deoxynucleoside-DNA + H2O = a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + L-tyrosine + H(+)

Direction not assertedBalance undeterminableRhea 65804

decanoyl-[ACP] + 4 reduced [2Fe-2S]-[ferredoxin] + 2 O2 + 4 H(+) = dec-9-ynoyl-[ACP] + 4 oxidized [2Fe-2S]-[ferredoxin] + 4 H2O

Direction not assertedBalance undeterminableRhea 65808

2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + AH2 + O2 = N(6)-[(2E)-4-hydroxy-3-methylbut-2-en-1-yl]-2-(methylsulfanyl)adenosine(37) in tRNA + A + H2O

Direction not assertedBalance undeterminableRhea 65812

2 Co(II)-[methylamine-specific corrinoid protein] + AH2 + ATP + H2O = 2 Co(I)-[methylamine-specific corrinoid protein] + A + ADP + phosphate + 3 H(+)

Direction not assertedBalance undeterminableRhea 65816

decanoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = dec-9-enoyl-[ACP] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 H2O

Direction not assertedBalance undeterminableRhea 65820

dec-9-enoyl-[ACP] + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = dec-9-ynoyl-[ACP] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 H2O

Direction not assertedBalance undeterminableRhea 65824

neryl diphosphate + H2O = nerol + diphosphate

Direction not assertedBalancedRhea 65828

2 Co(II)-[dimethylamine-specific corrinoid protein] + AH2 + ATP + H2O = 2 Co(I)-[dimethylamine-specific corrinoid protein] + A + ADP + phosphate + 3 H(+)

Direction not assertedBalance undeterminableRhea 65832

2 Co(II)-[trimethylamine-specific corrinoid protein] + AH2 + ATP + H2O = 2 Co(I)-[trimethylamine-specific corrinoid protein] + A + ADP + phosphate + 3 H(+)

Direction not assertedBalance undeterminableRhea 65836

Mg(2+)(out) + phosphate(in) + ATP(out) = Mg(2+)(in) + phosphate(out) + ATP(in)

Direction not assertedBalancedTransportRhea 65840

ADP(out) + phosphate(in) + H(+)(out) = ADP(in) + phosphate(out) + H(+)(in)

Direction not assertedBalancedTransportRhea 65844

a 3-oxo-Delta(1)-steroid + A + H2O = a steroid 1,3-dione + AH2

Direction not assertedBalance undeterminableRhea 65848

a 3-oxo-Delta(1)-steroid + H2O = a 1-hydroxy-3-oxo steroid

Direction not assertedBalance undeterminableRhea 65852

a 1-hydroxy-3-oxo steroid + A = a steroid 1,3-dione + AH2

Direction not assertedBalance undeterminableRhea 65856

Delta(1)-dihydrotestosterone + A + H2O = 17beta-hydroxyandrostan-1,3-dione + AH2

Direction not assertedBalancedRhea 65860

5alpha-androst-1-ene-3,17-dione + A + H2O = 5alpha-androstan-1,3,17-trione + AH2

Direction not assertedBalancedRhea 65864

Delta(1)-dihydrotestosterone + H2O = 1,17beta-dihydroxyandrostan-3-one

Direction not assertedBalancedRhea 65868

1,17beta-dihydroxyandrostan-3-one + A = 17beta-hydroxyandrostan-1,3-dione + AH2

Direction not assertedBalancedRhea 65872

5alpha-androst-1-ene-3,17-dione + H2O = 1-hydroxy-5alpha-androstan-3,17-dione

Direction not assertedBalancedRhea 65876

1-hydroxy-5alpha-androstan-3,17-dione + A = 5alpha-androstan-1,3,17-trione + AH2

Direction not assertedBalancedRhea 65880

3-hydroxy-L-kynurenine + 2-oxoglutarate = xanthurenate + L-glutamate + H2O

Direction not assertedBalancedRhea 65884

3-hydroxy-L-kynurenine + 2-oxoglutarate = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-glutamate

Direction not assertedBalancedRhea 65888

4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate = xanthurenate + H2O

Direction not assertedBalancedRhea 65892

L-kynurenine + glyoxylate = kynurenate + glycine + H2O

Left to rightBalancedRhea 65896

3-hydroxy-L-kynurenine + glyoxylate = xanthurenate + glycine + H2O

Left to rightBalancedRhea 65900

3-hydroxy-L-kynurenine + glyoxylate = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + glycine

Direction not assertedBalancedRhea 65904

3-hydroxy-L-kynurenine + pyruvate = xanthurenate + L-alanine + H2O

Direction not assertedBalancedRhea 65908

3-hydroxy-L-kynurenine + pyruvate = 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate + L-alanine

Direction not assertedBalancedRhea 65912

L-kynurenine + pyruvate = kynurenate + L-alanine + H2O

Direction not assertedBalancedRhea 65916

L-kynurenine + pyruvate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-alanine

Direction not assertedBalancedRhea 65920

2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine = 2-heptyl-1-methoxy-4(1H)-quinolinone + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 65924

3-bromo-2-heptyl-1-hydroxy-4(1H)-quinolinone + S-adenosyl-L-methionine = 3-bromo-2-heptyl-1-methoxy-4(1H)-quinolinone + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 65928

3-methyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + S-adenosyl-L-methionine = 3,5-dimethyl-1-oxo-2-[3-oxo-3-(pyrrolidin-1-yl)propyl]-1,5-dihydrobenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 65932

beta-D-mannose = beta-D-glucose

Direction not assertedBalancedRhea 65936

GDP-alpha-D-glucose + (R)-glycerate = (2R)-2-O-(alpha-D-glucopyranosyl)-glycerate + GDP + H(+)

Direction not assertedBalancedRhea 65940

CTP + AH2 + S-adenosyl-L-methionine = 3'-deoxy-3',4'-didehydro-CTP + 5'-deoxyadenosine + L-methionine + A + H2O + H(+)

Direction not assertedBalancedRhea 65944

Page 268 of 372