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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

13,001–13,050 of 18,558 reactions from Rhea

4-hydroxy-3-[(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-2-one + NADPH + O2 + H(+) = 2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + NADP(+) + H2O
Direction not assertedBalancedRhea 64344
2-oxo-3-[(8S)-epoxy-(2E,6E)-farnesyl]-6-(pyridin-3-yl)-2H-pyran-4-olate + H(+) = deacetylpyripyropene E
Direction not assertedBalancedRhea 64348
hexanoyl-CoA + 3 malonyl-CoA + 3 H(+) = 2,4,6-trihydroxyphenylhexan-1-one + 3 CO2 + 4 CoA
Direction not assertedBalancedRhea 64352
2,4,6-trihydroxyphenylhexan-1-one + FADH2 + chloride + O2 = (3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O + H(+)
Direction not assertedBalancedRhea 64356
(3-chloro-2,4,6-trihydroxyphenyl)hexan-1-one + FADH2 + chloride + O2 = (3,5-dichloro-2,4,6-trihydroxyphenyl)hexan-1-one + FAD + 2 H2O
Direction not assertedBalancedRhea 64360
prostaglandin G2 = (15S)-15-hydroperoxy-prostaglandin E2
Left to right

Balanced

Rhea 64364

2,3-bis-O-(phytanyl)-sn-glycerol 1-phosphate + 8 A = 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phosphate + 8 AH2

Direction not assertedBalancedRhea 64368

beta-D-GalNAc-(1->4)-alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + H2O = alpha-L-IdoA-(1->3)-beta-D-GalNAc-4-sulfate-(1->4)-alpha-L-IdoA-(1->3)-D-GalNAc-4-sulfate + N-acetyl-D-galactosamine

Left to rightBalancedRhea 64372

a 2,3-bis-O-phytanyl-sn-glycerol 1-phospholipid + 8 A = a 2,3-bis-O-(geranylgeranyl)-sn-glycerol 1-phospholipid + 8 AH2

Direction not assertedBalance undeterminableRhea 64376

phytyl diphosphate + 3 A = (2E,6E,10E)-geranylgeranyl diphosphate + 3 AH2

Direction not assertedBalancedRhea 64380

N-acetyl-beta-D-6-sulfogalactosaminyl-(1->4)-alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine + H2O = alpha-L-iduronyl-(1->3)-N-acetyl-D-6-sulfogalactosamine + N-acetyl-D-6-sulfogalactosamine

Left to rightBalancedRhea 64384

sn-3-O-phytanylglycerol 1-phosphate + 4 A = sn-3-O-(geranylgeranyl)glycerol 1-phosphate + 4 AH2

Direction not assertedBalancedRhea 64388

a dipeptide(out) + H(+)(out) = a dipeptide(in) + H(+)(in)

Left to rightBalance undeterminableTransportRhea 64392

glycyl-sarcosine(out) + H(+)(out) = glycyl-sarcosine(in) + H(+)(in)

Left to rightBalancedTransportRhea 64396

an L-amino acid tripeptide(out) + H(+)(out) = an L-amino acid tripeptide(in) + H(+)(in)

Left to rightBalance undeterminableTransportRhea 64400

carnosine(out) + H(+)(out) = carnosine(in) + H(+)(in)

Left to rightBalancedTransportRhea 64404

N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) + 2 H(+)(out) = N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in) + 2 H(+)(in)

Direction not assertedBalancedTransportRhea 64408

L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate(out) + n H(+)(out) = L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate(in) + n H(+)(in)

Left to rightBalance undeterminableTransportRhea 64412

D-xylofuranose + NADP(+) = D-xylono-1,4-lactone + NADPH + H(+)

Direction not assertedBalancedRhea 64416

L-alanyl-L-proline(out) + H(+)(out) = L-alanyl-L-proline(in) + H(+)(in)

Left to rightBalancedTransportRhea 64420

L-leucyl-L-proline(out) + H(+)(out) = L-leucyl-L-proline(in) + H(+)(in)

Left to rightBalancedTransportRhea 64424

glycyl-L-proline(out) + H(+)(out) = glycyl-L-proline(in) + H(+)(in)

Left to rightBalancedTransportRhea 64428

L-alanyl-L-prolylglycine(out) + H(+)(out) = L-alanyl-L-prolylglycine(in) + H(+)(in)

Left to rightBalancedTransportRhea 64432

glycylglycyl-L-isoleucine(out) + H(+)(out) = glycylglycyl-L-isoleucine(in) + H(+)(in)

Left to rightBalancedTransportRhea 64436

glycylglycyl-L-proline(out) + H(+)(out) = glycylglycyl-L-proline(in) + H(+)(in)

Left to rightBalancedTransportRhea 64440

L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(9)-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H(+)

Left to rightBalance undeterminableRhea 64444

L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H(+)

Direction not assertedBalance undeterminableRhea 64448

L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(27)-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H(+)

Direction not assertedBalance undeterminableRhea 64452

L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine + 3 H(+)

Direction not assertedBalance undeterminableRhea 64456

acetyl phosphate + L-lysyl-[protein] = N(6)-acetyl-L-lysyl-[protein] + phosphate + H(+)

Direction not assertedBalance undeterminableRhea 64460

L-tyrosyl-[protein] + 2 O2 = L-topaquinyl-[protein] + H2O2 + H(+)

Direction not assertedBalance undeterminableRhea 64464

(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + NADP(+) = 4-methylsulfanyl-2-oxobutanoate + NADPH + H(+)

Direction not assertedBalancedRhea 64468

(2R)-2-hydroxy-4-(methylsulfanyl)butanoate + S-adenosyl-L-methionine = (2R)-4-(dimethylsulfaniumyl)-2-hydroxybutanoate + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 64472

4-[(2E,7S,8E,10E,13R,14R,16E,18E)-14-ethyl-7,13-dihydroxy-2,16,18-trimethylicosa-2,8,10,16,18-pentaenoyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate = 4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate

Direction not assertedBalancedRhea 64476

4-[(1R,2R,4aS,5S,8aR)-2-[(2R,3R,5E,7E)-3-ethyl-2-hydroxy-5,7-dimethylnona-5,7-dien-1-yl]-5-hydroxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydronaphthalene-1-carbonyl]-2-methylidene-5-oxo-2,5-dihydro-1H-pyrrol-3-olate = (1S,3R,6R,8R,9R,11R,14S,15S,19R,20R)-8-ethyl-9,15-dihydroxy-3,4,6,20-tetramethyl-21,23-dioxo-24-azapentacyclo[20.2.1.0(1,6).0(11,20).0(14,19)]pentacosa-4,12,22(25)-trien-25-olate

Direction not assertedBalancedRhea 64480

holo-[ACP] + 6 malonyl-CoA + acetyl-CoA + 6 H(+) = 3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] + 6 CO2 + 7 CoA

Direction not assertedBalance undeterminableRhea 64484

holo-[ACP] + 5 malonyl-CoA + acetyl-CoA + 5 H(+) = 3,5,7,9,11-pentaoxododecanoyl-[ACP] + 5 CO2 + 6 CoA

Direction not assertedBalance undeterminableRhea 64488

3,5,7,9,11,13-hexaoxotetradecanoyl-[ACP] = dehydrocitreoisocoumarin + holo-[ACP] + H2O

Direction not assertedBalance undeterminableRhea 64492

3,5,7,9,11-pentaoxododecanoyl-[ACP] = 6,8-dihydroxy-3-(2-oxopropyl)-isocoumarin + holo-[ACP] + H2O

Direction not assertedBalance undeterminableRhea 64496

3 malonyl-CoA + acetyl-CoA + S-adenosyl-L-methionine + H(+) = 3-methylorsellinate + S-adenosyl-L-homocysteine + 3 CO2 + 4 CoA

Direction not assertedBalancedRhea 64500

propanoyl-CoA + 3 malonyl-CoA + AH2 + 2 S-adenosyl-L-methionine + H(+) = 2-ethyl-4,6-dihydroxy-3,5-dimethylbenzaldehyde + A + 2 S-adenosyl-L-homocysteine + 3 CO2 + 4 CoA + H2O

Direction not assertedBalancedRhea 64504

4 malonyl-CoA + acetyl-CoA + AH2 + S-adenosyl-L-methionine + 3 H(+) = 2,4-dihydroxy-3-methyl-6-(2-oxopropyl)benzaldehyde + A + S-adenosyl-L-homocysteine + 4 CO2 + 5 CoA + H2O

Direction not assertedBalancedRhea 64508

(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl-[ACP] + 4 malonyl-CoA + AH2 + S-adenosyl-L-methionine + 3 H(+) = 6-[(3E,5E,7S)-5,7-dimethyl-2-oxonona-3,5-dienyl]-2,4-dihydroxy-3-methylbenzaldehyde + holo-[ACP] + A + S-adenosyl-L-homocysteine + 4 CO2 + 4 CoA + H2O

Direction not assertedBalance undeterminableRhea 64512

2-hydroxyethane-1-sulfonate + NAD(+) = sulfoacetaldehyde + NADH + H(+)

Direction not assertedBalancedRhea 64516

3 malonyl-CoA + acetyl-CoA + AH2 + 3 H(+) = orsellinaldehyde + A + 3 CO2 + 4 CoA + H2O

Direction not assertedBalancedRhea 64520

(2E,4E,6E)-octa-2,4,6-trienyl-[ACP] + 4 malonyl-CoA + AH2 + 3 H(+) = 2,4-dihydroxy-6-[(3E,5E,7E)-2-oxonona-3,5,7-trienyl]benzaldehyde + holo-[ACP] + A + 4 CO2 + 4 CoA + H2O

Direction not assertedBalance undeterminableRhea 64524

decanoyl-[ACP] + 4 malonyl-CoA + AH2 + S-adenosyl-L-methionine + 3 H(+) = 2,4-dihydroxy-3-methyl-6-(2-oxoundecyl)benzaldehyde + holo-[ACP] + A + S-adenosyl-L-homocysteine + 4 CO2 + 4 CoA + H2O

Direction not assertedBalance undeterminableRhea 64528

an N-(1,2 saturated very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + 2 Fe(III)-[cytochrome b5] + H2O

Direction not assertedBalance undeterminableRhea 64532

an N-(2R-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = a 1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + a 1,2-diacyl-sn-glycerol

Direction not assertedBalance undeterminableRhea 64536

an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) = an alpha-D-mannosyl-6-(1D-myo-inositol phospho)-(1<->6)-1D-myo-inositol-1-phospho-N-[(R)-2-hydroxy-very-long-chain fatty acyl]-(R)-4-hydroxysphingoid base + a 1,2-diacyl-sn-glycerol

Direction not assertedBalance undeterminableRhea 64540

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