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1,251–1,300 of 12,877 reactions from Human-GEM
3(S),10(R)-OH-octadeca-6-trans-4,12-cis-trienoyl-CoA[m] + H2O[m] = 3(S),10(R)-OH-octadeca-6-trans-4,12-cis-trienoate[m] + CoA[m] + H+[m]
Left to rightBalancedEC 3.1.2.2Leukotriene metabolismHuman-GEM MAR01278
3(S),10(R)-OH-octadeca-6-trans-4,12-cis-trienoyl-CoA[x] + H2O[x] = 3(S),10(R)-OH-octadeca-6-trans-4,12-cis-trienoate[x] + CoA[x] + H+[x]
Left to rightBalancedEC 3.1.2.2Leukotriene metabolismHuman-GEM MAR01279
10,11-dihydro-12-epi-LTB4[c] + NADP+[c] = 10,11-dihydro-12-oxo-LTB4[c] + H+[c] + NADPH[c]
ReversibleBalancedEC 1.1.1.184Leukotriene metabolismHuman-GEM MAR01280
10,11-dihydro-12-epi-LTB4[m] + NADP+[m] = 10,11-dihydro-12-oxo-LTB4[m] + H+[m] + NADPH[m]
ReversibleBalancedEC 1.1.1.184Leukotriene metabolism
10,11-dihydro-12-epi-LTB4[x] + NADP+[x] = 10,11-dihydro-12-oxo-LTB4[x] + H+[x] + NADPH[x]
ReversibleBalancedEC 1.1.1.184Leukotriene metabolismHuman-GEM MAR01282
10,11-dihydro-12-epi-LTB4[c] = 10,11-dihydro-12-epi-LTB4[x]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR01283
10,11-dihydro-12-epi-LTB4[c] = 10,11-dihydro-12-epi-LTB4[m]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR01284
10,11-dihydro-12-epi-LTB4[c] = 10,11-dihydro-LTB4[c]
ReversibleBalancedLeukotriene metabolismHuman-GEM MAR01285
leukotriene E4[c] = leukotriene E4[x]
Left to rightBalancedTransportTransport reactionsHuman-GEM MAR01286
H+[x] + leukotriene E4[x] + NADPH[x] + O2[x] = 20-hydroxy-LTE4[x] + H2O[x] + NADP+[x]
Left to rightBalancedEC 1.14.13.34Leukotriene metabolismHuman-GEM MAR01287
20-hydroxy-LTE4[x] + NAD+[x] = 20-oxo-LTE4[x] + H+[x] + NADH[x]
Left to rightBalancedEC 1.1.1.1Leukotriene metabolismHuman-GEM MAR01288
20-oxo-LTE4[x] + H2O[x] + NAD+[x] = 20-COOH-LTE4[x] + 2 H+[x] + NADH[x]
Left to rightBalancedEC 1.2.1.3Leukotriene metabolismHuman-GEM MAR01289
20-COOH-LTE4[x] + ATP[x] + CoA[x] = 20-COOH-LTE4-CoA[x] + AMP[x] + PPi[x]
Left to rightBalancedEC 6.2.1.3Leukotriene metabolismHuman-GEM MAR01290
20-COOH-LTE4-CoA[x] + FAD[x] = (18E)-20-oxo-20-CoA-LTE4[x] + FADH2[x]
Left to rightBalancedEC 1.3.3.6Leukotriene metabolismHuman-GEM MAR01291
(18E)-20-oxo-20-CoA-LTE4[x] + H2O[x] = 18(R)-hydroxy-20-oxo-20-CoA-LTE4[x]
Left to rightBalancedEC 4.2.1.17Leukotriene metabolismHuman-GEM MAR01292
18(R)-hydroxy-20-oxo-20-CoA-LTE4[x] + NAD+[x] = 20-COOH-18-oxo-LTE4-CoA[x] + H+[x] + NADH[x]
Left to rightBalancedEC 1.1.1.35, 1.1.1.211Leukotriene metabolismHuman-GEM MAR01293
20-COOH-18-oxo-LTE4-CoA[x] + CoA[x] = acetyl-CoA[x] + omega-COOH-dinor-LTE4-CoA[x]
Left to rightBalancedEC 2.3.1.16Leukotriene metabolismHuman-GEM MAR01294
18-COOH-LTE4[x] + CoA[x] + H+[x] = H2O[x] + omega-COOH-dinor-LTE4-CoA[x]
ReversibleBalancedEC 3.1.2.2Leukotriene metabolismHuman-GEM MAR01295
FAD[x] + omega-COOH-dinor-LTE4-CoA[x] = 18-COOH-(16E)-dinor-LTE5-CoA[x] + FADH2[x]
Left to rightBalancedEC 1.3.3.6Leukotriene metabolismHuman-GEM MAR01296
18-COOH-(15E)-dinor-LTE4-CoA[x] + NADP+[x] = 18-COOH-(16E)-dinor-LTE5-CoA[x] + H+[x] + NADPH[x]
ReversibleBalancedEC 1.3.1.34Leukotriene metabolismHuman-GEM MAR01297
16e-18-oxo-18-CoA-dinor-LTE4[x] = 18-COOH-(15E)-dinor-LTE4-CoA[x]
ReversibleBalancedEC 5.3.3.8Leukotriene metabolismHuman-GEM MAR01298
16e-18-oxo-18-CoA-dinor-LTE4[x] + H2O[x] = 16(S)-hydroxy-18-oxo-18-CoA-LTE4[x]
Left to rightBalancedEC 4.2.1.17Leukotriene metabolismHuman-GEM MAR01299
16(S)-hydroxy-18-oxo-18-CoA-LTE4[x] + NAD+[x] = 16,18-oxo-18-CoA-dinor-LTE4[x] + H+[x] + NADH[x]
Left to rightBalancedEC 1.1.1.35, 1.1.1.211Leukotriene metabolismHuman-GEM MAR01300
16e-18-oxo-18-CoA-dinor-LTE4[x] + CoA[x] + H2O[x] = acetyl-CoA[x] + 5 H+[x] + omega-COOH-tetranor-LTE3-CoA[x]
Left to rightUnbalancedEC 2.3.1.16Leukotriene metabolismHuman-GEM MAR01301
H+[x] + H2O[x] + omega-COOH-tetranor-LTE3-CoA[x] = CoA[x] + omega-COOH-tetranor-LTE3[x]
Left to rightUnbalancedEC 3.1.2.27, 2.3.1.65Leukotriene metabolismHuman-GEM MAR01302
FAD[x] + 3 H+[x] + omega-COOH-tetranor-LTE3-CoA[x] = (13E)-tetranor-16-oxo-16-CoA-LTE4[x] + FADH2[x]
Left to rightUnbalancedEC 1.3.3.6Leukotriene metabolismHuman-GEM MAR01303
(13E)-tetranor-16-oxo-16-CoA-LTE4[x] + H2O[x] = (13E)-tetranor-16-carboxy-LTE4[x] + CoA[x] + H+[x]
Left to rightBalancedEC 3.1.2.2Leukotriene metabolismHuman-GEM MAR01304
arachidonate[r] + 2 O2[r] = prostaglandin G2[r]
Left to rightBalancedEC 1.14.99.1Prostaglandin biosynthesisHuman-GEM MAR01305
prostaglandin G2[c] = prostaglandin G2[r]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR01306
2 H+[r] + prostaglandin G2[r] = H2O[r] + prostaglandin H2[r]
Left to rightUnbalancedEC 1.14.99.1Prostaglandin biosynthesisHuman-GEM MAR01307
prostaglandin H2[r] = prostaglandin I2[r]
Left to rightBalancedEC 5.3.99.4Prostaglandin biosynthesisHuman-GEM MAR01308
prostaglandin I2[c] = prostaglandin I2[r]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR01309
6-oxo-prostaglandin F1alpha[r] = H2O[r] + prostaglandin I2[r]
ReversibleBalancedProstaglandin biosynthesisHuman-GEM MAR01310
prostaglandin H2[c] = prostaglandin H2[r]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR01311
prostaglandin H2[c] = prostaglandin E2[c]
Left to rightBalancedEC 5.3.99.3Prostaglandin biosynthesisHuman-GEM MAR01312
prostaglandin H2[r] = thromboxane A2[r]
Left to rightBalancedEC 5.3.99.5Prostaglandin biosynthesisHuman-GEM MAR01313
4-aminobutyrate[c] + ATP[c] + H2O[c] = 4-aminobutyrate[e] + ADP[c] + H+[c] + Pi[c]
Left to rightBalancedTransportTransport reactionsHuman-GEM MAR01314
H2O[r] + thromboxane A2[r] = thromboxane B2[r]
ReversibleBalancedProstaglandin biosynthesisHuman-GEM MAR01315
thromboxane B2[c] = thromboxane B2[r]
ReversibleBalancedTransportTransport reactionsHuman-GEM MAR01316
11-dehydro-thromboxane B2[c] + H+[c] + NADH[c] = NAD+[c] + thromboxane B2[c]
ReversibleBalancedProstaglandin biosynthesisHuman-GEM MAR01317
6-oxo-prostaglandin F1alpha[c] = H2O[c] + prostaglandin I2[c]
ReversibleBalancedProstaglandin biosynthesisHuman-GEM MAR01318
6-oxo-prostaglandin E1[c] + H+[c] + NADH[c] = 6-oxo-prostaglandin F1alpha[c] + NAD+[c]
ReversibleBalancedProstaglandin biosynthesisHuman-GEM MAR01319
6-oxo-prostaglandin F1alpha[c] + 2 H+[c] + 2 NADH[c] = H2O[c] + 2 NAD+[c] + prostaglandin F1alpha[c]
ReversibleBalancedProstaglandin biosynthesisHuman-GEM MAR01320
H2O[c] + prostaglandin A2[c] = prostaglandin E2[c]
ReversibleBalancedEC 4.2.1.-Prostaglandin biosynthesisHuman-GEM MAR01321
prostaglandin A2[c] = prostaglandin C2[c]
ReversibleBalancedEC 5.3.-.-Prostaglandin biosynthesisHuman-GEM MAR01322
prostaglandin B2[c] = prostaglandin C2[c]
ReversibleBalancedEC 5.3.3.9Prostaglandin biosynthesisHuman-GEM MAR01323
H2O[c] + prostaglandin B2[c] = prostaglandin E2[c]
ReversibleBalancedProstaglandin biosynthesisHuman-GEM MAR01324
NAD+[c] + prostaglandin F2alpha[c] = H+[c] + NADH[c] + prostaglandin H2[c]
Left to rightBalancedEC 1.1.1.188Prostaglandin biosynthesisHuman-GEM MAR01325
NADP+[c] + prostaglandin F2alpha[c] = H+[c] + NADPH[c] + prostaglandin H2[c]
Left to rightBalancedEC 1.1.1.188Prostaglandin biosynthesisHuman-GEM MAR01326
NADP+[c] + prostaglandin F2alpha[c] = H+[c] + NADPH[c] + prostaglandin E2[c]
Left to rightBalancedEC 1.1.1.184, 1.1.1.189Prostaglandin biosynthesisHuman-GEM MAR01327