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CompoundsSubstances with curated findings
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ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
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Reference

Evidence

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Reactions
Reach

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Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

12,651–12,700 of 18,558 reactions from Rhea

N(4)-acetyl-2'-deoxycytidine + H2O = 2'-deoxycytidine + acetate + H(+)
Direction not assertedBalancedRhea 62936
N(4)-acetylcytosine + H2O = cytosine + acetate + H(+)
Direction not assertedBalancedRhea 62940
(S,S)-2,5-di-(p-hydroxybenzyl)piperazine + reduced [NADPH--hemoprotein reductase] + O2 = (1S,8R,14S)-6,9-dioxo-15,17-diazatetracyclo[12.2.2.1(3,7).1(8,12)]icosa-3(20),4,6,10,12(19)-tetraen-7-ide + oxidized [NADPH--hemoprotein reductase] + 2 H2O + 2 H(+)
Direction not assertedBalance undeterminableRhea 62944
(1S,8R,14S)-6,9-dioxo-15,17-diazatetracyclo[12.2.2.1(3,7).1(8,12)]icosa-3(20),4,6,10,12(19)-tetraen-7-ide + 2 NADPH + 3 H(+) = (1S,7R,8R,14S)-15,17-diazatetracyclo[12.2.2.1(3,7).1(8,12)]icosa-3(20),12(19)-diene-6,9-dione + 2 NADP(+)
Direction not assertedBalancedRhea 62948
(1S,7R,8R,14S)-15,17-diazatetracyclo[12.2.2.1(3,7).1(8,12)]icosa-3(20),12(19)-diene-6,9-dione + S-adenosyl-L-methionine = herquline C + S-adenosyl-L-homocysteine + H(+)
Direction not assertedBalancedRhea 62952
herquline C = herquline A

? Direction not asserted

Balanced

Rhea 62956

7-dehydrocholesterol(in) = 7-dehydrocholesterol(out)

Direction not assertedBalancedTransportRhea 62960

beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP-beta-L-fucose = alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-D-galactosamine + GDP + H(+)

Left to rightBalancedRhea 62964

(R)-lactate + NADP(+) = pyruvate + NADPH + H(+)

Direction not assertedBalancedRhea 62968

3 malonyl-CoA + acetyl-CoA + 2 H(+) = orsellinate + 3 CO2 + 4 CoA

Direction not assertedBalancedRhea 62972

(9Z,12Z,15Z)-octadecatrienamide + H2O = (9Z,12Z,15Z)-octadecatrienoate + NH4(+)

Left to rightBalancedRhea 62976

(9Z)-hexadecenamide + H2O = (9Z)-hexadecenoate + NH4(+)

Direction not assertedBalancedRhea 62980

hexadecanamide + H2O = hexadecanoate + NH4(+)

Left to rightBalancedRhea 62984

dodecanamide + H2O = dodecanoate + NH4(+)

Direction not assertedBalancedRhea 62988

tetradecamide + H2O = tetradecanoate + NH4(+)

Left to rightBalancedRhea 62992

(8Z,11Z,14Z)-eicosatrienamide + H2O = (8Z,11Z,14Z)-eicosatrienoate + NH4(+)

Left to rightBalancedRhea 62996

(11Z,14Z,17Z)-eicosatrienamide + H2O = (11Z,14Z,17Z)-eicosatrienoate + NH4(+)

Left to rightBalancedRhea 63000

(11Z,14Z)-eicosadienamide + H2O = (11Z,14Z)-eicosadienoate + NH4(+)

Left to rightBalancedRhea 63004

(6Z)-octadecenamide + H2O = (6Z)-octadecenoate + NH4(+)

Left to rightBalancedRhea 63008

orsellinate + (2E,6E)-farnesyl diphosphate = ilicicolinate B + diphosphate

Direction not assertedBalancedRhea 63012

(5Z,8Z,11Z,14Z)-eicosatetraenamide + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + NH4(+)

Left to rightBalancedRhea 63016

(9Z,12Z)-octadecadienamide + H2O = (9Z,12Z)-octadecadienoate + NH4(+)

Left to rightBalancedRhea 63020

(13Z)-docosenamide + H2O = (13Z)-docosenoate + NH4(+)

Direction not assertedBalancedRhea 63024

(15Z)-tetracosenamide + H2O = (15Z)-tetracosenoate + NH4(+)

Left to rightBalancedRhea 63028

a fatty acylamide + H2O = a fatty acid + NH4(+)

Direction not assertedBalance undeterminableRhea 63032

octadecanamide + H2O = octadecanoate + NH4(+)

Direction not assertedBalancedRhea 63036

lovastatin + H2O = lovastatin carboxylate + H(+)

Direction not assertedBalancedRhea 63040

mevastatin + H2O = mevinic carboxylate + H(+)

Direction not assertedBalancedRhea 63044

pravastatin lactone + H2O = pravastatin + H(+)

Direction not assertedBalancedRhea 63048

1-O-methyl-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H2O = methanol + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)

Left to rightBalancedRhea 63052

3 malonyl-CoA + acetyl-CoA + S-adenosyl-L-methionine + H(+) = 5-methylorsellinate + S-adenosyl-L-homocysteine + 3 CO2 + 4 CoA

Direction not assertedBalancedRhea 63056

5-methylorsellinate + ATP + NADPH + H(+) = 2,4-dihydroxy 5,6-dimethylbenzaldehyde + AMP + diphosphate + NADP(+)

Direction not assertedBalancedRhea 63060

3 malonyl-CoA + acetyl-CoA + 3 H(+) = tetraacetate lactone + 3 CO2 + 4 CoA

Direction not assertedBalancedRhea 63064

2 malonyl-CoA + acetyl-CoA + 2 H(+) = triacetate lactone + 2 CO2 + 3 CoA

Direction not assertedBalancedRhea 63068

3 malonyl-CoA + acetyl-CoA + 3 H(+) = orcinol + 4 CO2 + 4 CoA

Direction not assertedBalancedRhea 63072

3 malonyl-CoA + acetyl-CoA + 3 H(+) = 2-acetylphloroglucinol + 3 CO2 + 4 CoA

Direction not assertedBalancedRhea 63076

ilicicolinate B + AH2 + ATP = ilicicolin B + A + AMP + diphosphate

Direction not assertedBalancedRhea 63080

ilicicolin B + FADH2 + chloride + O2 = ilicicolin A + FAD + 2 H2O + H(+)

Direction not assertedBalancedRhea 63084

a ribonucleotide in U6 snRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in U6 snRNA + S-adenosyl-L-homocysteine + H(+)

Left to rightBalance undeterminableRhea 63088

ilicicolin A + NADPH + O2 + H(+) = ilicicolin A epoxide + NADP(+) + H2O

Direction not assertedBalancedRhea 63092

ilicicolin A epoxide = ilicicolin C

Direction not assertedBalancedRhea 63096

ilicicolin C + NADPH + O2 + H(+) = ascochlorin + NADP(+) + 2 H2O

Direction not assertedBalancedRhea 63100

ilicicolin A epoxide + NADPH + O2 + H(+) = 16-hydroxy-ilicicolin A epoxide + NADP(+) + H2O

Direction not assertedBalancedRhea 63104

16-hydroxy-ilicicolin A epoxide = ascofuranol

Direction not assertedBalancedRhea 63108

ascofuranol + A = ascofuranone + AH2

Direction not assertedBalancedRhea 63112

peroxynitrite = nitrate

Left to rightBalancedRhea 63116

(11Z)-eicosenamide + H2O = (11Z)-eicosenoate + NH4(+)

Left to rightBalancedRhea 63120

N-octadecanoyl ethanolamine + H2O = octadecanoate + ethanolamine

Left to rightBalancedRhea 63124

N-docosanoyl-ethanolamine + H2O = docosanoate + ethanolamine

Left to rightBalancedRhea 63128

apo-[alkylcobalamin reductase] + methylcob(III)alamin + glutathione = S-methyl glutathione + cob(I)alamin-[alkylcobalamin reductase] + H(+)

Left to rightBalance undeterminableRhea 63132

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