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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Chemistry

Reactions
Reach

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Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

12,501–12,550 of 18,558 reactions from Rhea

AMP + ATP = adenosine 3'-diphosphate,5'-phosphate + AMP + H(+)
Direction not assertedBalancedRhea 62336
(+)-premalbrancheamide + bromide + FADH2 + O2 = (+)-malbrancheamide C + FAD + 2 H2O
Direction not assertedBalancedRhea 62340
6-hydroxydeoxybrevianamide E + dimethylallyl diphosphate = notoamide S + diphosphate
Direction not assertedBalancedRhea 62344
notoamide E + NADPH + O2 + H(+) = notoamide C + NADP(+) + H2O
Direction not assertedBalancedRhea 62348
notoamide E + NADPH + O2 + H(+) = notoamide D + NADP(+) + H2O
Direction not assertedBalancedRhea 62352
8-oxo-GDP + H2O = 8-oxo-GMP + phosphate + H(+)
Left to rightBalancedRhea 62356
FMN-N(5)-peroxide + uracil = (Z)-3-ureidoacrylate + FMN-N(5)-oxide + 2 H(+)

Direction not assertedBalancedRhea 62360

FMN-N(5)-peroxide + thymine = FMN-N(5)-oxide + (Z)-2-methylureidoacrylate + 2 H(+)

Direction not assertedBalancedRhea 62364

Fe(2+)(out) + 2 hydrogencarbonate(out) = Fe(2+)(in) + 2 hydrogencarbonate(in)

Left to rightBalancedTransportRhea 62368

uridine(54) in tRNA + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADPH + H(+) = 5-methyluridine(54) in tRNA + (6S)-5,6,7,8-tetrahydrofolate + NADP(+)

Direction not assertedBalancedRhea 62372

2,4-didehydro-3-deoxy-L-rhamnonate + H2O = (S)-lactate + pyruvate + H(+)

Direction not assertedBalancedRhea 62376

carbaryl + H2O + H(+) = 1-naphthol + methylamine + CO2

Direction not assertedBalancedRhea 62380

cyclic (2R)-2,3-bisphosphoglycerate + H2O = (2R)-2,3-bisphosphoglycerate + 2 H(+)

Direction not assertedBalancedRhea 62384

[(1->2)-beta-D-glucosyl](n) + H2O = [(1->2)-beta-D-glucosyl](n-2) + sophorose

Direction not assertedBalance undeterminableRhea 62388

levoglucosan + NAD(+) = 3-dehydrolevoglucosan + NADH + H(+)

Direction not assertedBalancedRhea 62392

(1S,2S)-pseudoephedrine + NAD(+) = (S)-2-methylamino-1-phenylpropan-1-one + NADH + H(+)

Direction not assertedBalancedRhea 62396

(1R,2S)-ephedrine + NAD(+) = (S)-2-methylamino-1-phenylpropan-1-one + NADH + H(+)

Direction not assertedBalancedRhea 62400

(R)-2-hydroxyhexadecanoate + O2 = pentadecanoate + CO2 + H2O

Direction not assertedBalancedRhea 62404

3,3'-di-O-methyl-4alpha-mannobiose + S-adenosyl-L-methionine = 1,3,3'-tri-O-methyl-4alpha-mannobiose + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 62408

(E)-feruloyl-CoA + H2O = vanillin + acetyl-CoA

Direction not assertedBalancedRhea 62412

(E)-4-coumaroyl-CoA + H2O = 4-hydroxybenzaldehyde + acetyl-CoA

Direction not assertedBalancedRhea 62416

a (R)-2-hydroxy fatty acid + O2 = a fatty acid + CO2 + H2O

Direction not assertedBalance undeterminableRhea 62420

(E)-caffeoyl-CoA + H2O = 3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA

Direction not assertedBalancedRhea 62424

3-hydroxy-3-(3,4-dihydroxyphenyl)propanoyl-CoA = 3,4-dihydroxybenzaldehyde + acetyl-CoA

Direction not assertedBalancedRhea 62428

a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + S-methyl-5'-thioadenosine + H(+)

Direction not assertedBalance undeterminableRhea 62432

L-lyxonate = 2-dehydro-3-deoxy-L-arabinonate + H2O

Direction not assertedBalancedRhea 62436

[(1->4)-alpha-D-galacturonosyl methyl ester](n) = [(1->4)-alpha-D-galacturonosyl methyl ester](n-1) + 4-deoxy-6-O-methyl-L-threo-hex-4-enopyranuronate

Direction not assertedBalance undeterminableRhea 62440

L-canavanine + L-ornithine = L-canaline + L-arginine + H(+)

Direction not assertedBalancedRhea 62444

L-glutamyl-5'-AMP + holo-[peptidyl-carrier protein] = L-glutamyl-[peptidyl-carrier protein] + AMP + H(+)

Direction not assertedBalance undeterminableRhea 62448

holo-[peptidyl-carrier protein] + L-glutamate + ATP = L-glutamyl-[peptidyl-carrier protein] + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 62452

L-glutamate + ATP + H(+) = L-glutamyl-5'-AMP + diphosphate

Direction not assertedBalancedRhea 62456

holo-[aryl-carrier protein] + 3,4-dihydroxybenzoate + ATP = 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 62460

1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + H2O = 2-nonadioyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)

Left to rightBalancedRhea 62464

3,4-dihydroxybenzoate + ATP + H(+) = 3,4-dihydroxybenzoyl-5'-AMP + diphosphate

Direction not assertedBalancedRhea 62468

1-hexadecanoyl-2-nonadioyl-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 2-nonadioyl-sn-glycero-3-phosphocholine + 1-hexadecanoyl-N-(acetyl)-sphing-4-enine

Left to rightBalancedRhea 62472

3,4-dihydroxybenzoyl-5'-AMP + holo-[aryl-carrier protein] = 3,4-dihydroxybenzoyl-[aryl-carrier protein] + AMP + H(+)

Direction not assertedBalance undeterminableRhea 62476

1-hexadecanoyl-2-glutaroyl-sn-glycero-3-phosphocholine + H2O = 2-glutaroyl-sn-glycero-3-phosphocholine + hexadecanoate + H(+)

Left to rightBalancedRhea 62480

1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + H2O = 2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + hexadecanoate + H(+)

Left to rightBalancedRhea 62484

1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + H2O = 2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + hexadecanoate + H(+)

Left to rightBalancedRhea 62488

holo-[peptidyl-carrier protein] + L-arginine + ATP = L-arginyl-[peptidyl-carrier protein] + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 62492

L-arginine + ATP + H(+) = L-arginyl-AMP + diphosphate

Direction not assertedBalancedRhea 62496

L-arginyl-AMP + holo-[peptidyl-carrier protein] = L-arginyl-[peptidyl-carrier protein] + AMP + H(+)

Direction not assertedBalance undeterminableRhea 62500

3-amino-5-hydroxybenzoate + holo-[aryl-carrier protein] + ATP = 3-amino-5-hydroxybenzoyl-[aryl-carrier protein] + AMP + diphosphate

Direction not assertedBalance undeterminableRhea 62504

1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + N-(acetyl)-sphing-4-enine = 1-(9Z-octadecenoyl)-N-(acetyl)-sphing-4-enine + (9Z-octadecenoyl)-sn-glycero-3-phosphocholine

Direction not assertedBalancedRhea 62508

melatonin + 2-oxoglutarate + O2 = 2-hydroxymelatonin + succinate + CO2

Direction not assertedBalancedRhea 62512

a beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GA2 + UDP + H(+)

Left to rightBalance undeterminableRhea 62516

a cytidine in rRNA + S-adenosyl-L-methionine = an N(4)-methylcytidine in rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 62520

cytidine(839) in 12S rRNA + S-adenosyl-L-methionine = N(4)-methylcytidine(839) in 12S rRNA + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 62524

digoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) = dihydrodigoxin + 2 Fe(III)-[cytochrome c]

Direction not assertedBalance undeterminableRhea 62528

digitoxin + 2 Fe(II)-[cytochrome c] + 3 H(+) = dihydrodigitoxin + 2 Fe(III)-[cytochrome c]

Direction not assertedBalance undeterminableRhea 62532

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