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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Organisms
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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

1,201–1,250 of 18,558 reactions from Rhea

2 a Fe(II)-siderophore + NAD(+) + H(+) = 2 a Fe(III)-siderophore + NADH
Direction not assertedBalancedRhea 15061
N(4)-benzoylagmatine + H2O = benzoate + agmatine
Direction not assertedBalancedRhea 15065
3-devinyl-3-(1-hydroxyethyl)chlorophyllide a = chlorophyllide a + H2O
Direction not assertedBalancedRhea 15069
3-D-glucuronosyl-N(2),6-disulfo-beta-D-glucosamine + H2O = N(2),6-disulfo-D-glucosamine + D-glucuronate
Direction not assertedBalancedRhea 15073
N-[(R)-pantothenoyl]-L-cysteine + H(+) = (R)-pantetheine + CO2
Direction not assertedBalancedRhea 15077
acetate + ATP + CoA = acetyl-CoA + ADP + phosphate
Direction not assertedBalancedRhea 15081
an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O = an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + N-acetyl-D-galactosamine

Direction not assertedBalance undeterminableRhea 15085

(R)-lactate + A = pyruvate + AH2

Direction not assertedBalancedRhea 15089

L-tyrosine + 2-oxoglutarate = 3-(4-hydroxyphenyl)pyruvate + L-glutamate

Direction not assertedBalancedRhea 15093

5-formimidoyltetrahydrofolate + L-glutamate = N-formimidoyl-L-glutamate + (6S)-5,6,7,8-tetrahydrofolate

Right to leftBalancedRhea 15097

meso-2,6-diaminopimelate + H(+) = L-lysine + CO2

Direction not assertedBalancedRhea 15101

kaempferol + S-adenosyl-L-methionine = kaempferide + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 15105

2-dehydro-3-deoxy-D-gluconate + NADP(+) = (4S,5S)-4,5-dihydroxy-2,6-dioxohexanoate + NADPH + H(+)

Direction not assertedBalancedRhea 15109

5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5,6beta-triol

Left to rightBalancedRhea 15113

3'-dephospho-CoA + ATP = 2'-(5''-triphospho-alpha-D-ribosyl)-3'-dephospho-CoA + adenine

Direction not assertedBalancedRhea 15117

dithioerythritol + thiosulfate = cis-1,2-dithiane-4,5-diol + hydrogen sulfide + sulfite + 2 H(+)

Direction not assertedBalancedRhea 15121

alpha-D-glucosaminyl-[heparan sulfate](n) + acetyl-CoA = N-acetyl-alpha-D-glucosaminyl-[heparan sulfate](n) + CoA + H(+)

Direction not assertedBalance undeterminableRhea 15125

(4S)-limonene + reduced [NADPH--hemoprotein reductase] + O2 = (1S,6R)-isopiperitenol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 15129

L-glutamate + NAD(+) + H2O = 2-oxoglutarate + NH4(+) + NADH + H(+)

Direction not assertedBalancedRhea 15133

galactitol 1-phosphate + NAD(+) = keto-L-tagatose 6-phosphate + NADH + H(+)

Direction not assertedBalancedRhea 15137

4-methylphenol + 4 oxidized [azurin] + H2O = 4 reduced [azurin] + 4-hydroxybenzaldehyde + 4 H(+)

Direction not assertedBalance undeterminableRhea 15141

D-maltose = alpha,alpha-trehalose

Direction not assertedBalancedRhea 15145

pyridoxine 5'-phosphate + O2 = pyridoxal 5'-phosphate + H2O2

Left to rightBalancedRhea 15149

4-hydroxybenzoate + UDP-alpha-D-glucose = 4-(beta-D-glucosyloxy)benzoate + UDP + H(+)

Direction not assertedBalancedRhea 15153

4-hydroxyphenylacetate + NADPH + O2 + H(+) = homogentisate + NADP(+) + H2O

Direction not assertedBalancedRhea 15157

4-hydroxyphenylacetate + NADH + O2 + H(+) = homogentisate + NAD(+) + H2O

Direction not assertedBalancedRhea 15161

sarcosine + O2 + H2O = methylamine + glyoxylate + H2O2

Direction not assertedBalancedRhea 15165

N-succinyl-L-glutamate + H2O = L-glutamate + succinate

Direction not assertedBalancedRhea 15169

H2O2 + NADPH + H(+) = NADP(+) + 2 H2O

Left to rightBalancedRhea 15173

a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)

Left to rightBalance undeterminableRhea 15177

an acyl-CoA(out) + ATP + H2O = an acyl-CoA(in) + ADP + phosphate + H(+)

Direction not assertedBalance undeterminableTransportRhea 15181

succinyl-CoA + L-arginine = N(2)-succinyl-L-arginine + CoA + H(+)

Direction not assertedBalancedRhea 15185

2 Fe(III)-[cytochrome c553] + formate = 2 Fe(II)-[cytochrome c553] + CO2 + H(+)

Direction not assertedBalance undeterminableRhea 15189

dGTP + H2O = 2'-deoxyguanosine + triphosphate + H(+)

Left to rightBalancedRhea 15193

a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + S-adenosyl-L-homocysteine + H(+)

Left to rightBalance undeterminableRhea 15197

6-hydroxymellein + S-adenosyl-L-methionine = 6-methoxymellein + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 15201

a di-trans,poly-cis-dolichyl diphosphooligosaccharide + H2O = an oligosaccharide-(1->4)-N-acetyl-beta-D-glucosamine-(1->4)-N-acetyl-alpha-D-glucosamine 1-phosphate + a di-trans,poly-cis-dolichyl phosphate + 2 H(+)

Direction not assertedBalance undeterminableRhea 15205

(2R,3R)-tartrate + NAD(+) = 2-hydroxy-3-oxosuccinate + NADH + H(+)

Direction not assertedBalancedRhea 15209

N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + succinyl-CoA = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CoA

Right to leftBalance undeterminableRhea 15213

ecdysone + hexadecanoyl-CoA = ecdysone hexadecanoate + CoA

Direction not assertedBalancedRhea 15217

a CDP-1,2-diacyl-sn-glycerol + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + CMP + 2 H(+)

Direction not assertedBalance undeterminableRhea 15221

dTTP + alpha-D-glucose 1-phosphate + H(+) = dTDP-alpha-D-glucose + diphosphate

Direction not assertedBalancedRhea 15225

alpha-D-mannose 1-phosphate + GTP + H(+) = GDP-alpha-D-mannose + diphosphate

ReversibleBalancedRhea 15229

nitric oxide + Fe(III)-[cytochrome c] + H2O = Fe(II)-[cytochrome c] + nitrite + 2 H(+)

Direction not assertedBalance undeterminableRhea 15233

2 Fe(III)-[cytochrome c2] + NADPH = 2 Fe(II)-[cytochrome c2] + NADP(+) + H(+)

Direction not assertedBalance undeterminableRhea 15237

taxa-4(20),11-dien-5alpha-yl acetate + reduced [NADPH--hemoprotein reductase] + O2 = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 15241

a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)

Direction not assertedBalance undeterminableRhea 15245

3,4,5-trihydroxybenzoate + UDP-alpha-D-glucose = 1-O-galloyl-beta-D-glucose + UDP

Direction not assertedBalancedRhea 15249

cis-aconitate + H(+) = itaconate + CO2

Left to rightBalancedRhea 15253

D-threonine = acetaldehyde + glycine

Direction not assertedBalancedRhea 15257

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