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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
PapersEvery paper a finding cites
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

Compounds
Outcomes
Proteins
Interactions
Papers
Articles

Chemistry

Reactions
Reach

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Pathways
Processes
Anatomy
Cell types
Organisms
Materials
Assessments
Diseases

Atlas Graph Twin Access

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

12,251–12,300 of 18,558 reactions from Rhea

indoxyl sulfate(in) + ATP + H2O = indoxyl sulfate(out) + ADP + phosphate + H(+)
Left to rightBalancedTransportRhea 61332
protoporphyrin IX(in) + ATP + H2O = protoporphyrin IX(out) + ADP + phosphate + H(+)
Left to rightBalancedTransportRhea 61336
(S)-methylmalonyl-CoA + H(+) = propanoyl-CoA + CO2
Left to rightBalancedRhea 61340
L-serine + O2 + H2O = 3-hydroxypyruvate + H2O2 + NH4(+)
Direction not assertedBalancedRhea 61344
estrone 3-sulfate(in) + ATP + H2O = estrone 3-sulfate(out) + ADP + phosphate + H(+)
Left to rightBalancedTransportRhea 61348
riboflavin(in) + ATP + H2O = riboflavin(out) + ADP + phosphate + H(+)
Left to rightBalancedTransportRhea 61352
methotrexate(in) + ATP + H2O = methotrexate(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 61356

pheophorbide a(in) + ATP + H2O = pheophorbide a(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 61360

dehydroepiandrosterone 3-sulfate(in) + ATP + H2O = dehydroepiandrosterone 3-sulfate(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 61364

4-methylumbelliferone sulfate(in) + ATP + H2O = 4-methylumbelliferone sulfate(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 61368

4-methylumbelliferone beta-D-glucuronate(in) + ATP + H2O = 4-methylumbelliferone beta-D-glucuronate(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 61372

5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl sulfate(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 61376

2,4-dinitrophenyl-S-glutathione(in) + ATP + H2O = 2,4-dinitrophenyl-S-glutathione(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 61380

5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(in) + ATP + H2O = 5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl)-1,3-benzothiazol-6-yl beta-D-glucuronate(out) + ADP + phosphate + H(+)

Left to rightBalancedTransportRhea 61384

biotin(in) + ATP + H2O = biotin(out) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 61388

N(6)-(D-psicosyl)-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-psicosyl)-L-lysyl-[protein] + ADP + H(+)

Left to rightBalance undeterminableRhea 61392

N(6)-(D-erythrulosyl)-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-erythrulosyl)-L-lysyl-[protein] + ADP + H(+)

Direction not assertedBalance undeterminableRhea 61396

N(6)-(D-ribulosyl)-L-lysine + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysine + ADP + H(+)

Direction not assertedBalancedRhea 61400

N-(D-ribulosyl)-cadaverine + ATP = N-(3-O-phospho-D-ribulosyl)-cadaverine + ADP + H(+)

Direction not assertedBalancedRhea 61404

N(6)-(D-erythrulosyl)-L-lysine + ATP = N(6)-(3-O-phospho-D-erythrulosyl)-L-lysine + ADP + H(+)

Direction not assertedBalancedRhea 61408

N-(D-erythrulosyl)-cadaverine + ATP = N-(3-O-phospho-D-erythrulosyl)-cadaverine + ADP + H(+)

Direction not assertedBalancedRhea 61412

(S)-8-oxocitronellyl enol = cis-trans-nepetalactol

Direction not assertedBalancedRhea 61416

(S)-8-oxocitronellyl enol = cis-cis-nepetalactol

Direction not assertedBalancedRhea 61420

cis-cis-nepetalactol + NAD(+) = cis-cis-nepetalactone + NADH + H(+)

Direction not assertedBalancedRhea 61424

cis-trans-nepetalactol + NAD(+) = cis-trans-nepetalactone + NADH + H(+)

Direction not assertedBalancedRhea 61428

(R)-8-oxocitronellyl enol + NADP(+) = (6E)-8-oxogeranial + NADPH + H(+)

Direction not assertedBalancedRhea 61432

ADP + H2O = AMP + phosphate + H(+)

Left to rightBalancedRhea 61436

S-(2-succino)-L-cysteine + acetyl-CoA = N-acetyl-S-(2-succino)-L-cysteine + CoA + H(+)

Direction not assertedBalancedRhea 61440

a tetracycline + NADPH + O2 + H(+) = an 11a-hydroxytetracycline + NADP(+) + H2O

Direction not assertedBalance undeterminableRhea 61444

tigecycline + NADPH + O2 + H(+) = 11a-hydroxytigecycline + NADP(+) + H2O

Direction not assertedBalancedRhea 61448

oxytetracycline + NADPH + O2 + H(+) = 11a-hydroxy-oxytetracycline + NADP(+) + H2O

Direction not assertedBalancedRhea 61452

7-chlorotetracycline + NADPH + O2 + H(+) = (1S,10S,10aS)-3-(CONH2)-9-Cl-1-(Me2N)-3,3a,4,10-(HO)4-10-Me-2,5-dioxo-1H,10aH,11H,11aH-cyclopenta[b]anthracen-6-olate + CO + NADP(+) + H2O

Direction not assertedBalancedRhea 61456

a cytidine in RNA + S-adenosyl-L-methionine = a 5-methylcytidine in RNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 61460

a cytidine in mRNA + S-adenosyl-L-methionine = a 5-methylcytidine in mRNA + S-adenosyl-L-homocysteine + H(+)

Left to rightBalance undeterminableRhea 61464

a cytidine in tRNA + S-adenosyl-L-methionine = a 5-methylcytidine in tRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 61468

a sphingoid base + hexadecanoyl-CoA = an N-hexadecanoyl-sphingoid base + CoA + H(+)

Left to rightBalance undeterminableRhea 61472

a sphingoid base + octadecanoyl-CoA = an N-octadecanoyl-sphingoid base + CoA + H(+)

Left to rightBalance undeterminableRhea 61476

a very long-chain fatty acyl-CoA + a sphingoid base = an N-(very-long-chain fatty acyl)-sphingoid base + CoA + H(+)

Left to rightBalance undeterminableRhea 61480

a cytidine in rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalance undeterminableRhea 61484

cytidine(50) in tRNA + S-adenosyl-L-methionine = 5-methylcytidine(50) in tRNA + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 61488

an ultra-long-chain fatty acyl-CoA + a sphingoid base = an N-(ultra-long-chain-acyl)-sphingoid base + CoA + H(+)

Left to rightBalance undeterminableRhea 61492

an inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-4R-hydroxysphingoid base + GDP-alpha-D-mannose = an alpha-D-mannosyl-(1<->6)-1D-myo-inositol-1-phospho-N-(2-hydroxy-very-long-chain fatty acyl)-(R)-4-hydroxysphingoid base + GDP + H(+)

Direction not assertedBalance undeterminableRhea 61496

delphinidin + UDP-alpha-D-glucose = delphinidin 3-O-beta-D-glucoside + UDP

Direction not assertedBalancedRhea 61500

pelargonidin + UDP-alpha-D-glucose = pelargonidin 3-O-beta-D-glucoside + UDP

Direction not assertedBalancedRhea 61504

peonidin + UDP-alpha-D-glucose = peonidin 3-O-beta-D-glucoside + UDP

Direction not assertedBalancedRhea 61508

malvidin + UDP-alpha-D-glucose = malvidin 3-O-beta-D-glucoside + UDP

Direction not assertedBalancedRhea 61512

dopamine + AH2 = 3-tyramine + A + H2O

Direction not assertedBalancedRhea 61520

(8Z,11Z,14Z)-eicosatrienoate + O2 = (15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate

Direction not assertedBalancedRhea 61524

an N-(omega-hydroxy-ultra-long chain fatty acyl)-sphingoid base + a (9Z,12Z)-octadecadienoyl-containing triacyl-sn-glycerol = an N-[omega-(9Z,12Z-octadecadienoyloxy)-O-ultra-long chain fatty acyl]-sphingoid base + a diacylglycerol

Left to rightBalance undeterminableRhea 61528

ent-kaur-16-ene + 6 reduced [2Fe-2S]-[ferredoxin] + 3 O2 + 5 H(+) = ent-kaur-16-en-19-oate + 6 oxidized [2Fe-2S]-[ferredoxin] + 4 H2O

Direction not assertedBalance undeterminableRhea 61532

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