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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
Cell typesCells, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Outcomes
Proteins
Interactions
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Articles

Chemistry

Reactions
Reach

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Processes
Anatomy
Cell types
Organisms
Materials
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Diseases

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

1,151–1,200 of 18,558 reactions from Rhea

(2E,6E,10E)-geranylgeranyl diphosphate = ent-copalyl diphosphate
Direction not assertedBalancedRhea 14841
L-aspartate 4-semialdehyde + pyruvate = (S)-2,3-dihydrodipicolinate + 2 H2O + H(+)
Direction not assertedBalancedRhea 14845
N-amidino-L-aspartate + H2O = urea + L-aspartate
Direction not assertedBalancedRhea 14849
4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl-CoA + chloride + H(+)
Direction not assertedBalancedRhea 14853
(indol-3-yl)acetate + L-lysine + ATP = N(6)-[(indole-3-yl)acetyl]-L-lysine + ADP + phosphate + H(+)
Direction not assertedBalancedRhea 14857
(S)-dihydroorotate + NADP(+) = orotate + NADPH + H(+)
Direction not assertedBalancedRhea 14861
tyramine + S-adenosyl-L-methionine = N-methyltyramine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 14865

an N-acetyl-alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O = an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + acetate

Direction not assertedBalance undeterminableRhea 14869

indole-3-ethanol + NAD(+) = indole-3-acetaldehyde + NADH + H(+)

Direction not assertedBalancedRhea 14873

L-glutamate + ATP = L-glutamyl 5-phosphate + ADP

Direction not assertedBalancedRhea 14877

3-sulfanyl-2-(sulfanylmethyl)propanoate + NAD(+) = asparagusate + NADH + H(+)

Direction not assertedBalancedRhea 14881

N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + H2O = ADP-D-ribose + L-arginyl-[protein]

Left to rightBalance undeterminableRhea 14885

(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate = (5Z,7E,9E,14Z,17Z)-icosapentaenoate

Direction not assertedBalancedRhea 14889

D-ornithine = (2R,4S)-2,4-diaminopentanoate

Direction not assertedBalancedRhea 14893

(2E,6E,10E)-geranylgeranyl diphosphate = casbene + diphosphate

Direction not assertedBalancedRhea 14901

5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O

Right to leftBalancedRhea 14905

L-gulonate + NADP(+) = aldehydo-D-glucuronate + NADPH + H(+)

Direction not assertedBalancedRhea 14909

thymidine + AMP = dTMP + adenosine

Direction not assertedBalancedRhea 14913

obtusifoliol + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = 4alpha-methyl-5alpha-ergosta-8,14,24(28)-trien-3beta-ol + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)

Direction not assertedBalance undeterminableRhea 14917

(indol-3-yl)acetate + UDP-alpha-D-glucose = 1-O-(indol-3-ylacetyl)-beta-D-glucose + UDP

Direction not assertedBalancedRhea 14921

D-mannitol 1-phosphate + NADP(+) = D-mannose 6-phosphate + NADPH + H(+)

Direction not assertedBalancedRhea 14925

testosterone + NAD(+) = androst-4-ene-3,17-dione + NADH + H(+)

Left to rightBalancedRhea 14929

N(6)-(4-O-phospho-D-erythrulosyl)-L-lysyl-[protein] + H2O = N(6)-(D-erythrulosyl)-L-lysyl-[protein] + phosphate

Direction not assertedBalance undeterminableRhea 14933

all-trans-antheraxanthin + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = all-trans-violaxanthin + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O

Direction not assertedBalance undeterminableRhea 14937

a 1,2-diacyl-sn-glycerol + UDP-alpha-D-galactose = a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol + UDP + H(+)

Direction not assertedBalance undeterminableRhea 14945

quinoline-4-carboxylate + A + H2O = 2-oxo-1,2-dihydroquinoline-4-carboxylate + AH2

Direction not assertedBalancedRhea 14949

S-formylglutathione + H2O = formate + glutathione + H(+)

Direction not assertedBalancedRhea 14961

an acyl phosphate + H2O = a carboxylate + phosphate + H(+)

Left to rightBalance undeterminableRhea 14965

trans-aconitate + S-adenosyl-L-methionine = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 14969

L-aspartate = D-aspartate

Direction not assertedBalancedRhea 14973

3-carboxy-2,5-dihydro-5-oxofuran-2-acetate = 3-carboxy-cis,cis-muconate

Direction not assertedBalancedRhea 14977

testosterone + NADP(+) = androst-4-ene-3,17-dione + NADPH + H(+)

Right to leftBalancedRhea 14981

(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (8R)-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoate

Direction not assertedBalancedRhea 14985

n malonyl-CoA + acetyl-CoA + 2n NADPH + 2n H(+) = a long-chain fatty acid + n CO2 + 2n NADP(+) + (n+1) CoA

Direction not assertedBalance undeterminableRhea 14993

deoxylimonoate + H2O = deoxylimononate D-ring-lactone + H(+)

Direction not assertedBalancedRhea 14997

keto-L-sorbose + NADP(+) = 5-dehydro-D-fructose + NADPH + H(+)

Direction not assertedBalancedRhea 15001

gibberellin A1 + 2-oxoglutarate + O2 = gibberellin A8 + succinate + CO2

Direction not assertedBalancedRhea 15005

(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)

Right to leftBalancedRhea 15009

3alpha(S)-strictosidine + H2O = secologanin + tryptamine

Direction not assertedBalancedRhea 15013

a phosphate monoester + H2O = an alcohol + phosphate

Left to rightBalance undeterminableRhea 15017

L-quinate + (E)-feruloyl-CoA = 4-O-feruloyl-D-quinate + CoA

Direction not assertedBalancedRhea 15021

xanthosine + S-adenosyl-L-methionine = 7-methylxanthosine + S-adenosyl-L-homocysteine

Direction not assertedBalancedRhea 15025

D-mannitol + NAD(+) = D-mannose + NADH + H(+)

Direction not assertedBalancedRhea 15029

pyridoxine + O2 = pyridoxal + H2O2

Direction not assertedBalancedRhea 15033

putrescine + S-adenosyl-L-methionine = N-methylputrescine + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 15037

bis-D-fructose 2',1:2,1'-dianhydride + H2O = inulobiose

Direction not assertedBalancedRhea 15041

N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)

Left to rightBalance undeterminableRhea 15045

GDP-alpha-D-glucose + H2O = D-glucose + GDP + H(+)

Direction not assertedBalancedRhea 15049

N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)

Left to rightBalancedRhea 15053

(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)

Direction not assertedBalance undeterminableRhea 15057

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