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CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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AnatomyTissues, by what is expressed there
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reactions
Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

11,901–11,950 of 18,558 reactions from Rhea

L-lysine + chloride + 2-oxoglutarate + O2 + H(+) = 4-chloro-L-lysine + succinate + CO2 + H2O
Direction not assertedBalancedRhea 59884
4-chloro-L-lysine + AH2 + O2 = L-2-amino-4-chloropent-4-enoate + formaldehyde + A + NH4(+) + H2O
Direction not assertedBalancedRhea 59888
L-2-amino-4-chloropent-4-enoate = L-propargylglycine + chloride + H(+)
Direction not assertedBalancedRhea 59892
L-propargylglycine + L-glutamate + ATP = L-gamma-glutamyl-L-propargylglycine + ADP + phosphate + H(+)
Direction not assertedBalancedRhea 59896
L-gamma-glutamyl-L-propargylglycine + 2-oxoglutarate + O2 = L-gamma-glutamyl-(3R)-L-beta-ethynylserine + succinate + CO2
Direction not assertedBalancedRhea 59900
octanal + NADP(+) + H2O = octanoate + NADPH + 2 H(+)
Left to rightBalancedRhea 59904
hexanal + NADP(+) + H2O = hexanoate + NADPH + 2 H(+)

Left to rightBalancedRhea 59908

(E)-4-hydroxynon-2-enal + NADP(+) + H2O = (E)-4-hydroxynon-2-enoate + NADPH + 2 H(+)

Left to rightBalancedRhea 59912

(2E)-octenal + NADP(+) + H2O = (2E)-octenoate + NADPH + 2 H(+)

Left to rightBalancedRhea 59916

(2E)-octenal + NAD(+) + H2O = (2E)-octenoate + NADH + 2 H(+)

Left to rightBalancedRhea 59920

D-sorbitol + NADP(+) = D-glucose + NADPH + H(+)

Right to leftBalancedRhea 59924

erythritol + NADP(+) = D-erythrose + NADPH + H(+)

Direction not assertedBalancedRhea 59928

ribitol + NADP(+) = D-ribose + NADPH + H(+)

Direction not assertedBalancedRhea 59932

3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oate + CoA + H(+)

Left to rightBalancedRhea 59936

2-methyloctadecanoyl-CoA + H2O = 2-methyloctadecanoate + CoA + H(+)

Left to rightBalancedRhea 59940

benzyl alcohol + NADP(+) = benzaldehyde + NADPH + H(+)

Direction not assertedBalancedRhea 59944

prostaglandin F2alpha-CoA + H2O = prostaglandin F2alpha + CoA + H(+)

Left to rightBalancedRhea 59948

2,6-dimethylheptanoyl-CoA + H2O = 2,6-dimethylheptanoate + CoA + H(+)

Left to rightBalancedRhea 59952

a (Z)-N-(sulfonatooxy)alkanimidothioate = a nitrile + sulfur + sulfate

Direction not assertedBalance undeterminableRhea 59956

N-acetyl-D-methionine = N-acetyl-L-methionine

Direction not assertedBalancedRhea 59960

octanoyl-CoA + L-seryl-[protein] = O-octanoyl-L-seryl-[protein] + CoA

Left to rightBalance undeterminableRhea 59964

L-threonyl-[protein] + octanoyl-CoA = O-octanoyl-L-threonyl-[protein] + CoA

Direction not assertedBalance undeterminableRhea 59968

decanoyl-CoA + L-seryl-[protein] = O-decanoyl-L-seryl-[protein] + CoA

Left to rightBalance undeterminableRhea 59972

2-phenylacetate + H(+) = toluene + CO2

Direction not assertedBalancedRhea 59976

8-oxo-dGTP + H2O = 8-oxo-dGDP + phosphate + H(+)

Left to rightBalancedRhea 59980

an N(2)-acyl-L-glutamine + H2O = a carboxylate + L-glutamine

Direction not assertedBalance undeterminableRhea 59984

cyclohexane-1-carbonyl-CoA + NADP(+) = cyclohex-1-ene-1-carbonyl-CoA + NADPH + H(+)

Direction not assertedBalancedRhea 59988

phloretate + oxidized [electron-transfer flavoprotein] + H(+) = (E)-4-coumarate + reduced [electron-transfer flavoprotein]

Direction not assertedBalance undeterminableRhea 59992

3-phenylpropanoate + oxidized [electron-transfer flavoprotein] + H(+) = (E)-cinnamate + reduced [electron-transfer flavoprotein]

Direction not assertedBalance undeterminableRhea 59996

hydroxymethylphosphonate + O2 = formate + phosphate + 2 H(+)

Direction not assertedBalancedRhea 60000

(L-glutamyl)(n+1)-gamma-L-glutamyl-L-glutamyl-[protein] + H2O = (L-glutamyl)(n)-gamma-L-glutamyl-L-glutamyl-[protein] + L-glutamate

Left to rightBalance undeterminableRhea 60004

a tRNA precursor + 2 CTP = a tRNA with a 3' CC end + 2 diphosphate

Direction not assertedBalance undeterminableRhea 60008

a tRNA with a 3' CC end + ATP = a tRNA with a 3' CCA end + diphosphate

Direction not assertedBalance undeterminableRhea 60012

(2E,6E)-farnesyl diphosphate = sesquisabinene B + diphosphate

Direction not assertedBalancedRhea 60016

(2E,6E)-farnesyl diphosphate = sesquisabinene A + diphosphate

Direction not assertedBalancedRhea 60020

(R,R)-chrysanthemyl diphosphate + H2O = (R,R)-chrysanthemol + diphosphate

Direction not assertedBalancedRhea 60024

(2E)-geranyl diphosphate + H2O = 4-terpineol + diphosphate

Direction not assertedBalancedRhea 60028

8-oxo-GTP + H2O = 8-oxo-GDP + phosphate + H(+)

Direction not assertedBalancedRhea 60032

N(2)-(3-hydroxy-3-methylhexanoyl)-L-glutaminate + H2O = 3-hydroxy-3-methylhexanoate + L-glutamine

Direction not assertedBalancedRhea 60036

N(2)-[(2E)-3-methylhex-2-enoyl]-L-glutaminate + H2O = (2E)-3-methylhex-2-enoate + L-glutamine

Direction not assertedBalancedRhea 60040

a beta-D-Gal-(1<->1')-ceramide + UDP-alpha-D-galactose = alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer + UDP + H(+)

Left to rightBalance undeterminableRhea 60044

a 3beta-hydroxy-4,4-dimethylsteroid + 3 NADH + 3 O2 + 2 H(+) = a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + 3 NAD(+) + 4 H2O

Direction not assertedBalance undeterminableRhea 60048

a 3beta-hydroxy-4,4-dimethylsteroid + NADH + O2 + H(+) = a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + NAD(+) + H2O

Direction not assertedBalance undeterminableRhea 60052

a 3beta-hydroxy-4beta-hydroxymethyl-4alpha-methylsteroid + NADH + O2 + H(+) = a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NAD(+) + 2 H2O

Direction not assertedBalance undeterminableRhea 60056

a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + UDP-alpha-D-galactose = alpha-D-Gal-(1->4)-beta-D-Gal-(1<->1')-Cer(d18:1(4E)) + UDP + H(+)

Direction not assertedBalance undeterminableRhea 60060

a 3beta-hydroxy-4beta-formyl-4alpha-methylsteroid + NADH + O2 = a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+) + H2O

Direction not assertedBalance undeterminableRhea 60064

4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + 3 NADH + 3 O2 + 2 H(+) = 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + 3 NAD(+) + 4 H2O

Direction not assertedBalancedRhea 60068

4,4-dimethyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2 + H(+) = 4beta-hydroxymethyl-4alpha-methylzymosterol + NAD(+) + H2O

Direction not assertedBalancedRhea 60072

4beta-hydroxymethyl-4alpha-methylzymosterol + NADH + O2 + H(+) = 4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) + 2 H2O

Direction not assertedBalancedRhea 60076

4beta-formylmethyl-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NADH + O2 = 4beta-carboxy-4alpha-methyl-5alpha-cholesta-8,24-dien-3beta-ol + NAD(+) + H2O

Direction not assertedBalancedRhea 60080

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