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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

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PathwaysReactions grouped under one name
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Reference

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

11,601–11,650 of 18,558 reactions from Rhea

FAD + NADPH + O2 + 2 H(+) = FADH2-C4alpha-hydroperoxide + NADP(+)
Direction not assertedBalancedRhea 58684
rifamycin SV + NADH + O2 = rifamycin SV para-naphthoquinone carboxamide + NAD(+) + H2O
Direction not assertedBalancedRhea 58688
rifamycin SV + FADH2-C4alpha-hydroperoxide + NADH + H(+) = rifamycin SV hemiaminal + FADH2 + NAD(+) + H2O
Direction not assertedBalancedRhea 58692
rifampicin + NADPH + O2 = rifampicin para-naphthoquinone carboxamide + NADP(+) + H2O + H(+)
Direction not assertedBalancedRhea 58696
FADH2-C4alpha-hydroperoxide + rifampicin + NADPH = rifampicin hemiaminal + FADH2 + NADP(+) + H2O + H(+)
Direction not assertedBalancedRhea 58700
rifampicin hemiaminal = rifampicin ortho-naphthoquinone carboxamide
Direction not assertedBalancedRhea 58704

rifampicin ortho-naphthoquinone carboxamide = rifampicin para-naphthoquinone carboxamide

Direction not assertedBalancedRhea 58708

rifampicin + NADH + O2 = rifampicin para-naphthoquinone carboxamide + NAD(+) + H2O + H(+)

Direction not assertedBalancedRhea 58712

FADH2-C4alpha-hydroperoxide + rifampicin + NADH = rifampicin hemiaminal + FADH2 + NAD(+) + H2O + H(+)

Direction not assertedBalancedRhea 58716

(S)-nicotine + NADPH + O2 = trans-(S)-nicotine N(1')-oxide + NADP(+) + H2O

Left to rightBalancedRhea 58720

adenosine(4220) in 28S rRNA + S-adenosyl-L-methionine = N(6)-methyladenosine(4220) in 28S rRNA + S-adenosyl-L-homocysteine + H(+)

Left to rightBalancedRhea 58724

adenosine in rRNA + S-adenosyl-L-methionine = N(6)-methyladenosine in rRNA + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 58728

5-methyl-CTP + H2O = 5-methyl-CMP + diphosphate + H(+)

Direction not assertedBalancedRhea 58732

5-methyl-UTP + H2O = 5-methyl-UMP + diphosphate + H(+)

Direction not assertedBalancedRhea 58736

psi-UTP + H2O = psi-UMP + diphosphate + H(+)

Direction not assertedBalancedRhea 58740

N(7)-methyl-GTP + H2O = N(7)-methyl-GMP + diphosphate + H(+)

Direction not assertedBalancedRhea 58744

desmethylnectriapyrone + S-adenosyl-L-methionine = nectriapyrone + S-adenosyl-L-homocysteine + H(+)

Direction not assertedBalancedRhea 58748

1-hexadecanoyl-2-(7-oxoheptanoyl)-sn-glycero-3-phosphocholine + NADPH + H(+) = 1-hexadecanoyl-2-(7-hydroxyheptanoyl)-sn-glycero-3-phosphocholine + NADP(+)

Direction not assertedBalancedRhea 58752

1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphoethanolamine + NADPH + H(+) = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphoethanolamine + NADP(+)

Direction not assertedBalancedRhea 58756

1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADPH + H(+) = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + NADP(+)

Direction not assertedBalancedRhea 58760

1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphate + NADPH + H(+) = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphate + NADP(+)

Direction not assertedBalancedRhea 58764

1-O-(1Z-hexadecenyl)-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + NADPH + H(+) = 1-O-(1Z-hexadecenyl)-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)

Direction not assertedBalancedRhea 58768

1-O-hexadecyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + NADPH + H(+) = 1-O-hexadecyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)

Direction not assertedBalancedRhea 58772

pyridine 3-methanol + NADP(+) = pyridine-3-carbaldehyde + NADPH + H(+)

Direction not assertedBalancedRhea 58776

a 5'-end triphospho-guanosine-ribonucleotide-snRNA + S-adenosyl-L-methionine = a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + S-adenosyl-L-homocysteine

Left to rightBalance undeterminableRhea 58780

a 5'-end methyltriphosphate-guanosine-ribonucleotide-snRNA + 2-oxoglutarate + O2 = a 5'-end triphospho-guanosine-ribonucleotide-snRNA + formaldehyde + succinate + CO2 + H(+)

Direction not assertedBalance undeterminableRhea 58784

3 malonyl-CoA + acetyl-CoA + 2 S-adenosyl-L-methionine + NADPH + 2 H(+) = desmethylnectriapyrone + 2 S-adenosyl-L-homocysteine + 3 CO2 + NADP(+) + 4 CoA + H2O

Direction not assertedBalancedRhea 58788

Fe(III)-petrobactin(out) + ATP + H2O = Fe(III)-petrobactin(in) + ADP + phosphate + H(+)

Direction not assertedBalancedTransportRhea 58792

a flavonol 7-O-beta-D-glucoside + malonyl-CoA = a flavonol 7-O-(6-O-malonyl-beta-D-glucoside) + CoA

Direction not assertedBalance undeterminableRhea 58796

3',3'-cGAMP + H2O = 5'-pApG-3' + H(+)

Direction not assertedBalancedRhea 58800

5'-pApG-3' + H2O = 5'-ApG-3' + phosphate

Direction not assertedBalancedRhea 58804

2',3'-cGAMP + 2 H2O = GMP + AMP + 2 H(+)

Left to rightBalancedRhea 58808

UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate + ATP + H2O = UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + AMP + diphosphate + H(+)

Direction not assertedBalancedRhea 58812

UDP-N-acetyl-alpha-D-muramoyl-L-alanine + L-glutamate + ATP = UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate + ADP + phosphate + H(+)

Direction not assertedBalancedRhea 58816

malonate + Na(+)(in) + H(+) = acetate + Na(+)(out) + CO2

Direction not assertedBalancedTransportRhea 58820

luteothin + 4 reduced [2Fe-2S]-[ferredoxin] + 2 O2 + 4 H(+) = aureothin + 4 oxidized [2Fe-2S]-[ferredoxin] + 3 H2O

Direction not assertedBalance undeterminableRhea 58824

(9S,10R)-epoxy-octadecanoate + H2O = 9R,10R-dihydroxyoctadecanoate

Direction not assertedBalancedRhea 58828

24-methylenecycloartanol + 6 Fe(II)-[cytochrome b5] + 3 O2 + 5 H(+) = 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O

Direction not assertedBalance undeterminableRhea 58832

24-methylenecycloartanol + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = 4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O

Direction not assertedBalance undeterminableRhea 58836

cholesterol sulfate + reduced [NADPH--hemoprotein reductase] + O2 = (24S)-hydroxycholesterol 3-sulfate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 58840

(6E)-8-hydroxygeranial + NAD(+) = (6E)-8-oxogeranial + NADH + H(+)

Direction not assertedBalancedRhea 58844

(6E)-8-hydroxygeraniol + NAD(+) = (6E)-8-hydroxygeranial + NADH + H(+)

Direction not assertedBalancedRhea 58848

(6E)-8-oxogeraniol + NAD(+) = (6E)-8-oxogeranial + NADH + H(+)

Direction not assertedBalancedRhea 58852

(6E)-8-hydroxygeraniol + NAD(+) = (6E)-8-oxogeraniol + NADH + H(+)

Direction not assertedBalancedRhea 58856

4alpha-hydroxymethyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = 4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 58860

4alpha-formyl,4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(II)-[cytochrome b5] + O2 + H(+) = 4alpha-carboxy-4beta,14alpha-dimethyl-9beta,19-cyclo-5alpha-ergost-24(24(1))-en-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O

Direction not assertedBalance undeterminableRhea 58864

24-methylidenelophenol + 6 Fe(II)-[cytochrome b5] + 3 O2 + 5 H(+) = 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 6 Fe(III)-[cytochrome b5] + 4 H2O

Direction not assertedBalance undeterminableRhea 58868

24-methylidenelophenol + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = 4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O

Direction not assertedBalance undeterminableRhea 58872

4alpha-hydroxymethyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = 4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + 2 H2O

Direction not assertedBalance undeterminableRhea 58876

4alpha-formyl-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(II)-[cytochrome b5] + O2 + H(+) = 4alpha-carboxy-ergosta-7,24(24(1))-dien-3beta-ol + 2 Fe(III)-[cytochrome b5] + H2O

Direction not assertedBalance undeterminableRhea 58880

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