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Evidence

CompoundsSubstances with curated findings
OutcomesMeasured endpoints
ProteinsTransporters and enzymes
InteractionsPairs that share biology
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ReactionsRhea and Human-GEM, by subsystem
ReachWhat a compound can become

Reference layer

PathwaysReactions grouped under one name
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MaterialsSubstances that are not one molecule
AssessmentsRegulatory determinations, transcribed
DiseasesFeatures, genes, and where each sits

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Reference

Evidence

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Reach

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Computational infrastructure for human biology, built on a provenance-aware knowledge graph. Findings retain their sources; research and simulation are the next layers.

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A reference for what the literature reports. Not medical advice.

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Index

Reactions

Reactions from Rhea and Human-GEM · Reach

reactions in the graph: 31,435

By source

Rhea18,558
Human-GEM12,877

Inferred

Reference data, not a finding. Evidence key

Filter reactions by equationSourceClear

Reactions

11,551–11,600 of 18,558 reactions from Rhea

a cytidine in mRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in mRNA + ADP + phosphate + CoA + H(+)
Left to rightBalance undeterminableRhea 58480
N-(acetyl)-sphing-4-enine + H2O = sphing-4-enine + acetate
Direction not assertedBalancedRhea 58484
4-(trimethylamino)butanoate + NADH + O2 + H(+) = succinate semialdehyde + trimethylamine + NAD(+) + H2O
Direction not assertedBalancedRhea 58488
Fe(III)-enterobactin(out) + ATP + H2O = Fe(III)-enterobactin(in) + ADP + phosphate + H(+)
Direction not assertedBalancedTransportRhea 58492
choline + NADH + O2 + H(+) = glycolaldehyde + trimethylamine + NAD(+) + H2O
Direction not assertedBalancedRhea 58496
glycine betaine + NADH + O2 + H(+) = trimethylamine + glyoxylate + NAD(+) + H2O
Direction not assertedBalancedRhea 58500

(1E)-4-oxobut-1-ene-1,2,4-tricarboxylate = (3Z)-2-oxo-4-carboxy-3-hexenedioate

Direction not assertedBalancedRhea 58504

(3Z)-2-oxo-4-carboxy-3-hexenedioate + H2O = (2S)-2-hydroxy-4-oxobutane-1,2,4-tricarboxylate

Direction not assertedBalancedRhea 58508

1-hexadecanoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine + NADPH + H(+) = 1-hexadecanoyl-2-(5-hydroxypentanoyl)-sn-glycero-3-phosphocholine + NADP(+)

Direction not assertedBalancedRhea 58512

(19E)-geissoschizine + reduced [NADPH--hemoprotein reductase] + O2 = 3,17-didehydrostemmadenine + oxidized [NADPH--hemoprotein reductase] + 2 H2O

Direction not assertedBalance undeterminableRhea 58516

(19E)-geissoschizine + reduced [NADPH--hemoprotein reductase] + O2 = akuammicine + formate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Direction not assertedBalance undeterminableRhea 58520

3,17-didehydrostemmadenine + NADPH + H2O = (16S)-deshydroxymethyl-stemmadenine + formate + NADP(+)

Direction not assertedBalancedRhea 58524

3,17-didehydrostemmadenine + NADPH + H2O = (16R)-deshydroxymethyl-stemmadenine + formate + NADP(+)

Direction not assertedBalancedRhea 58528

hexadecanoyl-CoA + glycine = N-hexadecanoylglycine + CoA + H(+)

Direction not assertedBalancedRhea 58536

N-dodecanoylglycine + 2 L-ascorbate + O2 = N-dodecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

Direction not assertedBalancedRhea 58540

N-tetradecanoylglycine + 2 L-ascorbate + O2 = N-tetradecanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

Direction not assertedBalancedRhea 58544

N-(9Z,12Z,15Z)-octadecatrienoylglycine + 2 L-ascorbate + O2 = N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

Direction not assertedBalancedRhea 58548

17-dehydrostemmadenine + H2O = (16R)-deshydroxymethyl-stemmadenine + formate

Direction not assertedBalancedRhea 58552

17-dehydrostemmadenine + H2O = (16S)-deshydroxymethyl-stemmadenine + formate

Direction not assertedBalancedRhea 58556

17-dehydrostemmadenine + NADP(+) = 3,17-didehydrostemmadenine + NADPH

Direction not assertedBalancedRhea 58560

15alpha-stemmadenine + NADP(+) = 17-dehydrostemmadenine + NADPH + 2 H(+)

Direction not assertedBalancedRhea 58564

15alpha-stemmadenine + acetyl-CoA = O-acetyl-15alpha-stemmadenine + CoA

Direction not assertedBalancedRhea 58568

O-acetyl-15alpha-stemmadenine + O2 = precondylocarpine acetate + H2O2

Direction not assertedBalancedRhea 58572

dihydroprecondylocarpine acetate + NADP(+) = precondylocarpine acetate + NADPH + H(+)

Direction not assertedBalancedRhea 58576

dihydroprecondylocarpine acetate = catharanthine + acetate + H(+)

Direction not assertedBalancedRhea 58580

dihydroprecondylocarpine acetate = (-)-tabersonine + acetate + H(+)

Direction not assertedBalancedRhea 58584

dihydroprecondylocarpine acetate + NADPH = (+)-vincadifformine + acetate + NADP(+)

Direction not assertedBalancedRhea 58588

1-hexadecanoyl-2-(9-oxononanoyl)-sn-glycero-3-phosphocholine + NADPH + H(+) = 1-hexadecanoyl-2-(9-hydroxynonanoyl)-sn-glycero-3-phosphocholine + NADP(+)

Direction not assertedBalancedRhea 58592

FADH2 + H2O2 = FAD + 2 H2O + H(+)

Direction not assertedBalancedRhea 58596

N-(9Z-octadecenoyl)glycine + 2 L-ascorbate + O2 = N-(9Z-octadecenoyl)-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

Direction not assertedBalancedRhea 58600

FAD + NADH + O2 + 2 H(+) = FADH2-C4alpha-hydroperoxide + NAD(+)

Direction not assertedBalancedRhea 58604

N-decanoylglycine + 2 L-ascorbate + O2 = N-decanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

Direction not assertedBalancedRhea 58608

N-octanoylglycine + 2 L-ascorbate + O2 = N-octanoyl-(2S)-hydroxyglycine + 2 monodehydro-L-ascorbate radical + H2O

Direction not assertedBalancedRhea 58612

N-octanoyl-(2S)-hydroxyglycine = octanamide + glyoxylate

Direction not assertedBalancedRhea 58616

N-decanoyl-(2S)-hydroxyglycine = decanamide + glyoxylate

Direction not assertedBalancedRhea 58620

N-dodecanoyl-(2S)-hydroxyglycine = dodecanamide + glyoxylate

Direction not assertedBalancedRhea 58624

rifamycin SV + FADH2-C4alpha-hydroperoxide + NADPH + H(+) = rifamycin SV hemiaminal + FADH2 + NADP(+) + H2O

Direction not assertedBalancedRhea 58628

N-tetradecanoyl-(2S)-hydroxyglycine = tetradecamide + glyoxylate

Direction not assertedBalancedRhea 58632

N-(9Z-octadecenoyl)-(2S)-hydroxyglycine = (9Z)-octadecenamide + glyoxylate

Direction not assertedBalancedRhea 58636

a 5'-end 5'-phospho-ribonucleoside-RNA + 2 S-adenosyl-L-methionine = a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + 2 S-adenosyl-L-homocysteine

Direction not assertedBalance undeterminableRhea 58640

N-(9Z,12Z,15Z)-octadecatrienoyl-(2S)-hydroxyglycine = (9Z,12Z,15Z)-octadecatrienamide + glyoxylate

Direction not assertedBalancedRhea 58644

rifamycin SV hemiaminal = rifamycin SV ortho-naphthoquinone carboxamide + H(+)

Direction not assertedBalancedRhea 58648

rifamycin SV ortho-naphthoquinone carboxamide = rifamycin SV para-naphthoquinone carboxamide

Direction not assertedBalancedRhea 58652

a 5'-end 5'-phospho-ribonucleoside-RNA + S-adenosyl-L-methionine = a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine

Direction not assertedBalance undeterminableRhea 58656

a 5'-end (5'-methylphospho)-ribonucleoside-RNA + S-adenosyl-L-methionine = a 5'-end (5'-bismethylphospho)-ribonucleoside-RNA + S-adenosyl-L-homocysteine

Direction not assertedBalance undeterminableRhea 58660

(S)-2-hydroxyglutarate + a quinone = a quinol + 2-oxoglutarate

Direction not assertedBalance undeterminableRhea 58664

3-deoxyfructose + NADP(+) = 3-deoxyglucosone + NADPH + H(+)

Direction not assertedBalancedRhea 58668

D-glucuronate = aldehydo-D-glucuronate

Direction not assertedBalancedRhea 58672

rifamycin SV + NADPH + O2 = rifamycin SV para-naphthoquinone carboxamide + NADP(+) + H2O

Direction not assertedBalancedRhea 58676

FADH2 + A = FAD + AH2 + H(+)

Direction not assertedBalancedRhea 58680

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